REVERSING MULTIDRUG RESISTANCE IN L1210 TUMOR-CELLS BY HYCANTHONE OR CHLOROPHENOXAMINE INVITRO AND INVIVO

Publication type:
Journal article
Metadata:
Autoren
  • T EFFERTH
  • T KLETT
  • J MATTERN
  • H OSSWALD
  • EW POMMERENKE
  • M STOHR
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1991GD36600038&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1791-7530
Externe Identifier
  • Clarivate Analytics Document Solution ID: GD366
  • PubMed Identifier: 1888160
ISSN
0250-7005
Ausgabe der Veröffentlichung
3
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • MULTIDRUG RESISTANCE
  • HYCANTHONE
  • CHLOROPHENOXAMINE
Paginierung
1275 - 1279
Datum der Veröffentlichung
1991
Status
Published
Titel
REVERSING MULTIDRUG RESISTANCE IN L1210 TUMOR-CELLS BY HYCANTHONE OR CHLOROPHENOXAMINE INVITRO AND INVIVO
Sub types
  • Article
Ausgabe der Zeitschrift
11

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
In the presence study we demonstrated that hycanthone and chlorophenoxamine can modulate the resistance of multidrug resistant (MDR) murine L1210 leukemia tumor lines in vitro and in vivo. The circumvention of MDR by hycanthone and chlorophenoxamine in vitro was demonstrated by a short-term test using tritiated nucleic acid precursors and by flow cytometrical measurement of accumulation of rhodamine 123. Furthermore, we treated mice bearing resistant L1210 ascites cells with doxorubicin and hycanthone or chlorophenoxamine. Hycanthone in combination with doxorubicin significantly inhibited tumor growth. We also found an improved therapeutic effect of doxorubicin plus chlorophenoxamine. Our results in vitro and in vivo indicate that hycanthone and chlorophenoxamine might be appropriate tools for the circumvention of MDR in human tumors.
Addresses
  • German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
Autoren
  • T Efferth
  • T Klett
  • J Mattern
  • H Osswald
  • EW Pommerenke
  • M Stöhr
  • M Volm
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 1888160
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
3
Zeitschrift
Anticancer research
Schlüsselwörter
  • Tumor Cells, Cultured
  • Animals
  • Mice
  • Leukemia L1210
  • Ethylamines
  • Rhodamines
  • Rhodamine 123
  • Hycanthone
  • Doxorubicin
  • Flow Cytometry
  • Structure-Activity Relationship
  • Drug Resistance
Sprache
eng
Medium
Print
Paginierung
1275 - 1279
Datum der Veröffentlichung
1991
Status
Published
Datum der Datenerfassung
1991
Titel
Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
11

Data source: Europe PubMed Central

Abstract
In the presence study we demonstrated that hycanthone and chlorophenoxamine can modulate the resistance of multidrug resistant (MDR) murine L1210 leukemia tumor lines in vitro and in vivo. The circumvention of MDR by hycanthone and chlorophenoxamine in vitro was demonstrated by a short-term test using tritiated nucleic acid precursors and by flow cytometrical measurement of accumulation of rhodamine 123. Furthermore, we treated mice bearing resistant L1210 ascites cells with doxorubicin and hycanthone or chlorophenoxamine. Hycanthone in combination with doxorubicin significantly inhibited tumor growth. We also found an improved therapeutic effect of doxorubicin plus chlorophenoxamine. Our results in vitro and in vivo indicate that hycanthone and chlorophenoxamine might be appropriate tools for the circumvention of MDR in human tumors.
Autoren
  • T Efferth
  • T Klett
  • J Mattern
  • H Osswald
  • EW Pommerenke
  • M Stöhr
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1888160
ISSN
0250-7005
Ausgabe der Veröffentlichung
3
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Animals
  • Doxorubicin
  • Drug Resistance
  • Ethylamines
  • Flow Cytometry
  • Hycanthone
  • Leukemia L1210
  • Mice
  • Rhodamine 123
  • Rhodamines
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
Sprache
eng
Country
Greece
Paginierung
1275 - 1279
Datum der Veröffentlichung
1991
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1991
Titel
Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
11

Data source: PubMed

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