OVEREXPRESSION OF P-GLYCOPROTEIN IN HUMAN LUNG-CARCINOMA XENOGRAFTS AFTER FRACTIONATED-IRRADIATION INVIVO

Publication type:
Journal article
Metadata:
Autoren
  • J MATTERN
  • T EFFERTH
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1991GD98500014&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2307/3577949
Externe Identifier
  • Clarivate Analytics Document Solution ID: GD985
  • PubMed Identifier: 1679564
ISSN
0033-7587
Ausgabe der Veröffentlichung
3
Zeitschrift
RADIATION RESEARCH
Paginierung
335 - 338
Datum der Veröffentlichung
1991
Status
Published
Titel
OVEREXPRESSION OF P-GLYCOPROTEIN IN HUMAN LUNG-CARCINOMA XENOGRAFTS AFTER FRACTIONATED-IRRADIATION INVIVO
Sub types
  • Article
Ausgabe der Zeitschrift
127

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • J Mattern
  • T Efferth
  • M Volm
DOI
10.2307/3577949
ISSN
0033-7587
Ausgabe der Veröffentlichung
3
Zeitschrift
Radiation Research
Paginierung
335 - 335
Datum der Veröffentlichung
1991
Status
Published
Herausgeber
JSTOR
Herausgeber URL
http://dx.doi.org/10.2307/3577949
Datum der Datenerfassung
2018
Titel
Overexpression of P-Glycoprotein in Human Lung Carcinoma Xenografts after Fractionated Irradiation in Vivo
Ausgabe der Zeitschrift
127

Data source: Crossref

Abstract
In vivo exposure of a human epidermoid lung carcinoma xenograft to seven irradiation treatments of 10 Gy in consecutive passages resulted in expression of resistance to vincristine. This about threefold drug resistance was detectable with a single dose of 1 mg/kg vincristine. Characterization of the radiation-pretreated subline showed that overexpression of P-glycoprotein, as determined by immunofluorescence and Mabs C219 and 265/F4, occurred in this tumor. After six X-ray fractions, only single positive cells were observed, whereas seven fractions produced an intense immunofluorescent reaction with both antibodies. Southern blot analyses indicated that no gene amplification had occurred. This result shows that irradiation can influence expression of P-glycoprotein and in this way influences drug resistance.
Addresses
  • German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
Autoren
DOI
10.2307/3577949
eISSN
1938-5404
Externe Identifier
  • PubMed Identifier: 1679564
Open access
false
ISSN
0033-7587
Ausgabe der Veröffentlichung
3
Zeitschrift
Radiation research
Schlüsselwörter
  • Animals
  • Humans
  • Mice
  • Carcinoma, Squamous Cell
  • Lung Neoplasms
  • Vincristine
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Radiotherapy Dosage
  • Transplantation, Heterologous
  • Neoplasm Transplantation
  • Gene Expression
  • Drug Resistance
  • Female
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
335 - 338
Datum der Veröffentlichung
1991
Status
Published
Datum der Datenerfassung
1991
Titel
Overexpression of P-glycoprotein in human lung carcinoma xenografts after fractionated irradiation in vivo.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
127

Data source: Europe PubMed Central

Abstract
In vivo exposure of a human epidermoid lung carcinoma xenograft to seven irradiation treatments of 10 Gy in consecutive passages resulted in expression of resistance to vincristine. This about threefold drug resistance was detectable with a single dose of 1 mg/kg vincristine. Characterization of the radiation-pretreated subline showed that overexpression of P-glycoprotein, as determined by immunofluorescence and Mabs C219 and 265/F4, occurred in this tumor. After six X-ray fractions, only single positive cells were observed, whereas seven fractions produced an intense immunofluorescent reaction with both antibodies. Southern blot analyses indicated that no gene amplification had occurred. This result shows that irradiation can influence expression of P-glycoprotein and in this way influences drug resistance.
Autoren
  • J Mattern
  • T Efferth
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1679564
ISSN
0033-7587
Ausgabe der Veröffentlichung
3
Zeitschrift
Radiat Res
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Animals
  • Carcinoma, Squamous Cell
  • Drug Resistance
  • Female
  • Gene Expression
  • Humans
  • Lung Neoplasms
  • Membrane Glycoproteins
  • Mice
  • Neoplasm Proteins
  • Neoplasm Transplantation
  • Radiotherapy Dosage
  • Transplantation, Heterologous
  • Vincristine
Sprache
eng
Country
United States
Paginierung
335 - 338
Datum der Veröffentlichung
1991
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1991
Titel
Overexpression of P-glycoprotein in human lung carcinoma xenografts after fractionated irradiation in vivo.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
127

Data source: PubMed

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