CIRCUMVENTION OF MULTIDRUG RESISTANCE IN HUMAN KIDNEY AND KIDNEY CARCINOMA INVITRO
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- M VOLM
- EW POMMERENKE
- T EFFERTH
- H LOHRKE
- J MATTERN
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1991FJ30600015&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1002/1097-0142(19910515)67:10<2484::AID-CNCR2820671016>3.0.CO;2-I
- Externe Identifier
- Clarivate Analytics Document Solution ID: FJ306
- PubMed Identifier: 1673084
- ISSN
- 0008-543X
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- CANCER
- Paginierung
- 2484 - 2489
- Datum der Veröffentlichung
- 1991
- Status
- Published
- Titel
- CIRCUMVENTION OF MULTIDRUG RESISTANCE IN HUMAN KIDNEY AND KIDNEY CARCINOMA INVITRO
- Sub types
- Article
- Ausgabe der Zeitschrift
- 67
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Manfred Volm
- Elke W Pommerenke
- Thomas Efferth
- Heinz Löhrke
- Jürgen Mattern
- DOI
- 10.1002/1097-0142(19910515)67:10<2484::aid-cncr2820671016>3.0.co;2-i
- eISSN
- 1097-0142
- ISSN
- 0008-543X
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Cancer
- Sprache
- en
- Paginierung
- 2484 - 2489
- Datum der Veröffentlichung
- 1991
- Status
- Published
- Herausgeber
- Wiley
- Herausgeber URL
- http://dx.doi.org/10.1002/1097-0142(19910515)67:10%3C2484::aid-cncr2820671016%3E3.0.co;2-i
- Datum der Datenerfassung
- 2020
- Titel
- Circumvention of multi-drug resistance in human kidney and kidney carcinomain vitro
- Ausgabe der Zeitschrift
- 67
Data source: Crossref
- Abstract
- This report investigated whether the calmodulin inhibitor, trifluoperazine, can circumvent multi-drug resistance both in primary tissue cultures of human kidney and kidney carcinoma. For detection of inherent multi-drug resistance, the expression of P-glycoprotein was determined by immunofluorescence and immunocytochemistry using the monoclonal antibody C219. For detection of doxorubicin resistance and reversal of this resistance by trifluoperazine, the incorporation of nucleic acid precursor was measured after addition of doxorubicin and trifluoperazine, respectively. Both P-glycoprotein expressing resistant normal and malignant kidney tissue cultures could be modified by trifluoperazine. However, sensitive normal kidney and kidney carcinoma cultures were little affected by trifluoperazine. Thus, circumvention of primary resistance to doxorubicin is not limited to tumor cells. This might have important implications for the use of resistance modifiers in the clinical setting.
- Addresses
- German Cancer Research Center, Department of Experimental Pathology, Heidelberg.
- Autoren
- M Volm
- EW Pommerenke
- T Efferth
- H Löhrke
- J Mattern
- DOI
- 10.1002/1097-0142(19910515)67:10<2484::aid-cncr2820671016>3.0.co;2-i
- eISSN
- 1097-0142
- Externe Identifier
- PubMed Identifier: 1673084
- Open access
- false
- ISSN
- 0008-543X
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Cancer
- Schlüsselwörter
- Kidney
- Tumor Cells, Cultured
- Humans
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Trifluoperazine
- Doxorubicin
- Membrane Glycoproteins
- Drug Resistance
- Reference Values
- Aged
- Aged, 80 and over
- Middle Aged
- Female
- Male
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Paginierung
- 2484 - 2489
- Datum der Veröffentlichung
- 1991
- Status
- Published
- Datum der Datenerfassung
- 1991
- Titel
- Circumvention of multi-drug resistance in human kidney and kidney carcinoma in vitro.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 67
Data source: Europe PubMed Central
- Abstract
- This report investigated whether the calmodulin inhibitor, trifluoperazine, can circumvent multi-drug resistance both in primary tissue cultures of human kidney and kidney carcinoma. For detection of inherent multi-drug resistance, the expression of P-glycoprotein was determined by immunofluorescence and immunocytochemistry using the monoclonal antibody C219. For detection of doxorubicin resistance and reversal of this resistance by trifluoperazine, the incorporation of nucleic acid precursor was measured after addition of doxorubicin and trifluoperazine, respectively. Both P-glycoprotein expressing resistant normal and malignant kidney tissue cultures could be modified by trifluoperazine. However, sensitive normal kidney and kidney carcinoma cultures were little affected by trifluoperazine. Thus, circumvention of primary resistance to doxorubicin is not limited to tumor cells. This might have important implications for the use of resistance modifiers in the clinical setting.
- Autoren
- M Volm
- EW Pommerenke
- T Efferth
- H Löhrke
- J Mattern
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/1673084
- DOI
- 10.1002/1097-0142(19910515)67:10<2484::aid-cncr2820671016>3.0.co;2-i
- ISSN
- 0008-543X
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Cancer
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Aged
- Aged, 80 and over
- Carcinoma, Renal Cell
- Doxorubicin
- Drug Resistance
- Female
- Humans
- Kidney
- Kidney Neoplasms
- Male
- Membrane Glycoproteins
- Middle Aged
- Reference Values
- Trifluoperazine
- Tumor Cells, Cultured
- Sprache
- eng
- Country
- United States
- Paginierung
- 2484 - 2489
- Datum der Veröffentlichung
- 1991
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1991
- Titel
- Circumvention of multi-drug resistance in human kidney and kidney carcinoma in vitro.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 67
Data source: PubMed
- Beziehungen:
- Property of