IMMUNOHISTOCHEMICAL DETECTION OF P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE AND DNA TOPOISOMERASE-II IN HUMAN TUMORS

Publication type:
Journal article
Metadata:
Autoren
  • T EFFERTH
  • J MATTERN
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1992JQ73000011&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: JQ730
  • PubMed Identifier: 1356260
ISSN
0030-2414
Ausgabe der Veröffentlichung
5
Zeitschrift
ONCOLOGY
Schlüsselwörter
  • P-GLYCOPROTEIN
  • GLUTATHIONE
  • S-TRANSFERASE
  • DNA TOPOISOMERASE-II
  • DRUG RESISTANCE
  • HUMAN TUMORS
Paginierung
368 - 375
Datum der Veröffentlichung
1992
Status
Published
Titel
IMMUNOHISTOCHEMICAL DETECTION OF P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE AND DNA TOPOISOMERASE-II IN HUMAN TUMORS
Sub types
  • Article
Ausgabe der Zeitschrift
49

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Thomas Efferth
  • Jürgen Mattern
  • Manfred Volm
DOI
10.1159/000227075
eISSN
1423-0232
ISSN
0030-2414
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncology
Sprache
en
Online publication date
2009
Paginierung
368 - 375
Datum der Veröffentlichung
1992
Status
Published
Herausgeber
S. Karger AG
Herausgeber URL
http://dx.doi.org/10.1159/000227075
Datum der Datenerfassung
2017
Titel
Immunohistochemical Detection of P Glycoprotein, Glutathione S Transferase and DNATopoisomerase II in Human Tumors
Ausgabe der Zeitschrift
49

Data source: Crossref

Abstract
The expression of the drug resistance markers P glycoprotein (P-170), glutathione S transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) was analyzed in 16 human kidney carcinoma cell lines, 18 hematological malignancies, and 14 human breast carcinomas. We found a tendency for coexpression of increased P-170 and GST-pi and of increased P-170 and decreased Topo II expression in kidney carcinoma cell lines. A similar tendency was found between P-170 and GST-pi expression in breast carcinomas. In contrast, hematological malignancies did not show such a coexpression of resistance markers. Furthermore, we found interrelationships between the expression of resistance markers, resistance to doxorubicin or vincristine, and doubling times of kidney carcinoma cell lines. This indicates that the proliferative activity of tumor cells plays a role for the expression of resistance markers and the development of resistance to cytostatic drugs.
Addresses
  • German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
Autoren
DOI
10.1159/000227075
eISSN
1423-0232
Externe Identifier
  • PubMed Identifier: 1356260
Open access
false
ISSN
0030-2414
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncology
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Neoplasms
  • Leukemia
  • Multiple Myeloma
  • Carcinoma
  • Breast Neoplasms
  • Kidney Neoplasms
  • Neoplasm Metastasis
  • DNA Topoisomerases, Type II
  • Glutathione Transferase
  • Membrane Glycoproteins
  • Immunohistochemistry
  • Drug Resistance
  • In Vitro Techniques
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
368 - 375
Datum der Veröffentlichung
1992
Status
Published
Datum der Datenerfassung
1992
Titel
Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
49

Data source: Europe PubMed Central

Abstract
The expression of the drug resistance markers P glycoprotein (P-170), glutathione S transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) was analyzed in 16 human kidney carcinoma cell lines, 18 hematological malignancies, and 14 human breast carcinomas. We found a tendency for coexpression of increased P-170 and GST-pi and of increased P-170 and decreased Topo II expression in kidney carcinoma cell lines. A similar tendency was found between P-170 and GST-pi expression in breast carcinomas. In contrast, hematological malignancies did not show such a coexpression of resistance markers. Furthermore, we found interrelationships between the expression of resistance markers, resistance to doxorubicin or vincristine, and doubling times of kidney carcinoma cell lines. This indicates that the proliferative activity of tumor cells plays a role for the expression of resistance markers and the development of resistance to cytostatic drugs.
Autoren
  • T Efferth
  • J Mattern
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1356260
DOI
10.1159/000227075
ISSN
0030-2414
Ausgabe der Veröffentlichung
5
Zeitschrift
Oncology
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Breast Neoplasms
  • Carcinoma
  • DNA Topoisomerases, Type II
  • Drug Resistance
  • Glutathione Transferase
  • Humans
  • Immunohistochemistry
  • In Vitro Techniques
  • Kidney Neoplasms
  • Leukemia
  • Membrane Glycoproteins
  • Multiple Myeloma
  • Neoplasm Metastasis
  • Neoplasms
  • Tumor Cells, Cultured
Sprache
eng
Country
Switzerland
Paginierung
368 - 375
Datum der Veröffentlichung
1992
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1992
Titel
Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
49

Data source: PubMed

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