ONCOPROTEIN (C-MYC, C-ERBB1, C-ERBB2, C-FOS) AND SUPPRESSOR GENE-PRODUCT (P53) EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE LUNG - CLINICAL AND BIOLOGICAL CORRELATIONS

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1992HM33100002&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: HM331
  • PubMed Identifier: 1348920
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • PROTOONCOGENE
  • SUPPRESSOR GENE
  • SQUAMOUS LUNG CARCINOMA
  • PROGNOSIS
Paginierung
11 - 20
Datum der Veröffentlichung
1992
Status
Published
Titel
ONCOPROTEIN (C-MYC, C-ERBB1, C-ERBB2, C-FOS) AND SUPPRESSOR GENE-PRODUCT (P53) EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE LUNG - CLINICAL AND BIOLOGICAL CORRELATIONS
Sub types
  • Article
Ausgabe der Zeitschrift
12

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
The expression of the protooncogene encoded proteins (c-erbB1, c-erb B2, c-myc, c-fos) and the suppressor gene product p53 was analyzed in 81 human squamous cell carcinomas of the lung and correlated with clinical parameters of the patients (patient survival, presence of metastases and tumor stage) and with biological characteristics of the tumors (tumor growth in nude mice, DNA-ploidy, proliferative activity, drug-resistance and P-glycoprotein or gluathione S-transferase expression). By means of immunohistochemistry, expression of c-erbB1 oncoprotein (EGF-receptor) was detected in 79% of the tumors, c-erbB2 (c-neu) proteins in 35%, c-myc proteins in 48%, c-fos proteins in 41%, and p53 in 43% of the tumors. Patients with c-erbB1 positive tumors had a poor prognosis (p = 0.021). In addition, these tumors were more frequently drug resistant (p = 0.0067). A significant correlation between the growth of the squamous lung carcinomas in nude mice and c-fos oncoprotein expression was demonstrated (p = 0.017). Therefore, EGF-receptor and c-fos products may serve as prognostic factors for the aggressiveness of squamous cell carcinomas of the lung and for the response of these tumors to chemotherapy. No significant correlation was found between the expression of the c-erbB1 or c-fos gene products and stage, metastasis and DNA-ploidy. In contrast to these results, no relationship was found between c-neu or c-myc gene products expression and any of the clinical or biological parameters examined. Aneuploid squamous cell carcinomas of the lung expressed p53 more frequently than diploid tumors (p = 0.027). However, there was no significant difference between p53 expression and stage, survival of patients, metastasis, growth of the tumors in nude mice, proliferative activity and drug-resistance of the tumors.
Addresses
  • German Cancer Research Center, Heidelberg.
Autoren
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 1348920
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
Anticancer research
Schlüsselwörter
  • Humans
  • Carcinoma, Squamous Cell
  • Lung Neoplasms
  • Receptor, erbB-2
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • ErbB Receptors
Sprache
eng
Medium
Print
Paginierung
11 - 20
Datum der Veröffentlichung
1992
Status
Published
Datum der Datenerfassung
1992
Titel
Oncoprotein (c-myc, c-erbB1, c-erbB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung. Clinical and biological correlations.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: Europe PubMed Central

Abstract
The expression of the protooncogene encoded proteins (c-erbB1, c-erb B2, c-myc, c-fos) and the suppressor gene product p53 was analyzed in 81 human squamous cell carcinomas of the lung and correlated with clinical parameters of the patients (patient survival, presence of metastases and tumor stage) and with biological characteristics of the tumors (tumor growth in nude mice, DNA-ploidy, proliferative activity, drug-resistance and P-glycoprotein or gluathione S-transferase expression). By means of immunohistochemistry, expression of c-erbB1 oncoprotein (EGF-receptor) was detected in 79% of the tumors, c-erbB2 (c-neu) proteins in 35%, c-myc proteins in 48%, c-fos proteins in 41%, and p53 in 43% of the tumors. Patients with c-erbB1 positive tumors had a poor prognosis (p = 0.021). In addition, these tumors were more frequently drug resistant (p = 0.0067). A significant correlation between the growth of the squamous lung carcinomas in nude mice and c-fos oncoprotein expression was demonstrated (p = 0.017). Therefore, EGF-receptor and c-fos products may serve as prognostic factors for the aggressiveness of squamous cell carcinomas of the lung and for the response of these tumors to chemotherapy. No significant correlation was found between the expression of the c-erbB1 or c-fos gene products and stage, metastasis and DNA-ploidy. In contrast to these results, no relationship was found between c-neu or c-myc gene products expression and any of the clinical or biological parameters examined. Aneuploid squamous cell carcinomas of the lung expressed p53 more frequently than diploid tumors (p = 0.027). However, there was no significant difference between p53 expression and stage, survival of patients, metastasis, growth of the tumors in nude mice, proliferative activity and drug-resistance of the tumors.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1348920
ISSN
0250-7005
Ausgabe der Veröffentlichung
1
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Carcinoma, Squamous Cell
  • ErbB Receptors
  • Humans
  • Lung Neoplasms
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-myc
  • Receptor, ErbB-2
  • Tumor Suppressor Protein p53
Sprache
eng
Country
Greece
Paginierung
11 - 20
Datum der Veröffentlichung
1992
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1992
Titel
Oncoprotein (c-myc, c-erbB1, c-erbB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung. Clinical and biological correlations.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: PubMed

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