ANTIBODY-DIRECTED THERAPY OF MULTIDRUG-RESISTANT TUMOR-CELLS

Publication type:
Journal article
Metadata:
Autoren
  • T EFFERTH
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1992HV30700002&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: HV307
  • PubMed Identifier: 1285219
ISSN
0736-0118
Ausgabe der Veröffentlichung
1
Zeitschrift
MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY
Schlüsselwörter
  • MULTIDRUG RESISTANCE
  • P-GLYCOPROTEIN
  • MONOCLONAL ANTIBODIES
  • IMMUNOTOXINS
  • BISPECIFIC ANTIBODIES
Paginierung
11 - 19
Datum der Veröffentlichung
1992
Status
Published
Titel
ANTIBODY-DIRECTED THERAPY OF MULTIDRUG-RESISTANT TUMOR-CELLS
Sub types
  • Article
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Thomas Efferth
  • Manfred Volm
DOI
10.1007/bf02989648
ISSN
0736-0118
Ausgabe der Veröffentlichung
1
Zeitschrift
Medical Oncology and Tumor Pharmacotherapy
Sprache
en
Paginierung
11 - 19
Datum der Veröffentlichung
1992
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1007/bf02989648
Datum der Datenerfassung
2021
Titel
Antibody-directed therapy of multidrug-resistant tumor cells
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
The major obstacle to effective cancer chemotherapy is the resistance of tumor cells to cytostatic agents. Tumor cells frequently express a multidrug-resistance (MDR) phenotype. In an effort to devise new strategies to overcome MDR, antibody-directed approaches for the eradication of MDR cells have been developed. Experimental data have shown that multidrug-resistant tumor cells can be efficiently killed by monoclonal antibodies, immunotoxins, or bispecific antibodies. The current experimental results indicate that an antibody-directed therapeutic approach to eradication of MDR cells might be a promising adjunct to conventional chemotherapy of cancer patients.
Addresses
  • German Cancer Centre, Heidelberg.
Autoren
DOI
10.1007/bf02989648
Externe Identifier
  • PubMed Identifier: 1285219
Open access
false
ISSN
0736-0118
Ausgabe der Veröffentlichung
1
Zeitschrift
Medical oncology and tumor pharmacotherapy
Schlüsselwörter
  • Tumor Cells, Cultured
  • Animals
  • Humans
  • Neoplasms
  • Carrier Proteins
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Immunotoxins
  • Antibodies, Bispecific
  • Antibodies, Monoclonal
  • Epitopes
  • Immunotherapy
  • Chemotherapy, Adjuvant
  • Drug Resistance
  • ErbB Receptors
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
11 - 19
Datum der Veröffentlichung
1992
Status
Published
Datum der Datenerfassung
1992
Titel
Antibody-directed therapy of multidrug-resistant tumor cells.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: Europe PubMed Central

Abstract
The major obstacle to effective cancer chemotherapy is the resistance of tumor cells to cytostatic agents. Tumor cells frequently express a multidrug-resistance (MDR) phenotype. In an effort to devise new strategies to overcome MDR, antibody-directed approaches for the eradication of MDR cells have been developed. Experimental data have shown that multidrug-resistant tumor cells can be efficiently killed by monoclonal antibodies, immunotoxins, or bispecific antibodies. The current experimental results indicate that an antibody-directed therapeutic approach to eradication of MDR cells might be a promising adjunct to conventional chemotherapy of cancer patients.
Autoren
  • T Efferth
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1285219
DOI
10.1007/BF02989648
ISSN
0736-0118
Ausgabe der Veröffentlichung
1
Zeitschrift
Med Oncol Tumor Pharmacother
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Animals
  • Antibodies, Bispecific
  • Antibodies, Monoclonal
  • Carrier Proteins
  • Chemotherapy, Adjuvant
  • Drug Resistance
  • Epitopes
  • ErbB Receptors
  • Humans
  • Immunotherapy
  • Immunotoxins
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Neoplasms
  • Tumor Cells, Cultured
Sprache
eng
Country
England
Paginierung
11 - 19
Datum der Veröffentlichung
1992
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1994
Titel
Antibody-directed therapy of multidrug-resistant tumor cells.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
9

Data source: PubMed

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