IMMUNOCYTOCHEMICAL DETECTION OF ONCOPROTEINS IN ANIMAL AND HUMAN TUMOR LINES WITH ACQUIRED OR INHERENT MULTIDRUG RESISTANCE

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1992JV49500005&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: JV495
  • PubMed Identifier: 1458514
ISSN
0361-090X
Ausgabe der Veröffentlichung
4
Zeitschrift
CANCER DETECTION AND PREVENTION
Schlüsselwörter
  • ONCOPROTEINS
  • MULTIDRUG RESISTANCE
  • IMMUNOCYTOCHEMISTRY
Paginierung
237 - 243
Datum der Veröffentlichung
1992
Status
Published
Titel
IMMUNOCYTOCHEMICAL DETECTION OF ONCOPROTEINS IN ANIMAL AND HUMAN TUMOR LINES WITH ACQUIRED OR INHERENT MULTIDRUG RESISTANCE
Sub types
  • Article
Ausgabe der Zeitschrift
16

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
In this presentation, we analyze the relationship between protein expression of the protooncogenes c-fos, c-erb B1, c-K-ras, and c-myc and acquired or inherent multidrug resistance (MDR) in a panel of animal (CHO, S 180, L 1210) and human (KTCTL 44, KTCTL 18, CX 1, CXF 94) tumor lines by means of immunocytochemistry. Increased expression of c-fos and c-erb B1 proteins is a constant feature of all resistant cell lines except L 1210 cells, which did not reveal any alteration in oncoprotein expression. No apparent relationship between c-K-ras and c-myc proteins and MDR was found. The immunocytochemical results were corroborated by radioimmunoassays (RIAs). The data indicate that c-fos and c-erb B1 might play a role in the development of MDR.
Addresses
  • German Cancer Research Center, Heidelberg.
Autoren
eISSN
1525-1500
Externe Identifier
  • PubMed Identifier: 1458514
Open access
false
ISSN
0361-090X
Ausgabe der Veröffentlichung
4
Zeitschrift
Cancer detection and prevention
Schlüsselwörter
  • CHO Cells
  • Tumor Cells, Cultured
  • Animals
  • Humans
  • Mice
  • Leukemia L1210
  • Sarcoma 180
  • Adenocarcinoma
  • Carcinoma, Renal Cell
  • Colonic Neoplasms
  • Kidney Neoplasms
  • Neoplasms, Experimental
  • Oncogene Proteins
  • Immunohistochemistry
  • Neoplasm Transplantation
  • Cell Division
  • Gene Expression
  • Drug Resistance
  • Oncogenes
  • Female
  • Cricetinae
Sprache
eng
Medium
Print
Paginierung
237 - 243
Datum der Veröffentlichung
1992
Status
Published
Datum der Datenerfassung
1992
Titel
Immunocytochemical detection of oncoproteins in animal and human tumor lines with acquired or inherent multidrug resistance.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
16

Data source: Europe PubMed Central

Abstract
In this presentation, we analyze the relationship between protein expression of the protooncogenes c-fos, c-erb B1, c-K-ras, and c-myc and acquired or inherent multidrug resistance (MDR) in a panel of animal (CHO, S 180, L 1210) and human (KTCTL 44, KTCTL 18, CX 1, CXF 94) tumor lines by means of immunocytochemistry. Increased expression of c-fos and c-erb B1 proteins is a constant feature of all resistant cell lines except L 1210 cells, which did not reveal any alteration in oncoprotein expression. No apparent relationship between c-K-ras and c-myc proteins and MDR was found. The immunocytochemical results were corroborated by radioimmunoassays (RIAs). The data indicate that c-fos and c-erb B1 might play a role in the development of MDR.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1458514
ISSN
0361-090X
Ausgabe der Veröffentlichung
4
Zeitschrift
Cancer Detect Prev
Schlüsselwörter
  • Adenocarcinoma
  • Animals
  • CHO Cells
  • Carcinoma, Renal Cell
  • Cell Division
  • Colonic Neoplasms
  • Cricetinae
  • Drug Resistance
  • Female
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms
  • Leukemia L1210
  • Mice
  • Neoplasm Transplantation
  • Neoplasms, Experimental
  • Oncogene Proteins
  • Oncogenes
  • Sarcoma 180
  • Tumor Cells, Cultured
Sprache
eng
Country
England
Paginierung
237 - 243
Datum der Veröffentlichung
1992
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1993
Titel
Immunocytochemical detection of oncoproteins in animal and human tumor lines with acquired or inherent multidrug resistance.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
16

Data source: PubMed

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