EXPRESSION OF SEVERAL RESISTANCE MECHANISMS IN UNTREATED HUMAN KIDNEY AND LUNG CARCINOMAS

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1992JJ23800003&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: JJ238
  • PubMed Identifier: 1354430
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • RESISTANCE MECHANISMS
  • P-GLYCOPROTEIN
  • GLUTATHIONE S-TRANSFERASE-PI
  • TOPOISOMERASE-II
  • RENAL CELL CARCINOMAS
  • NON-SMALL-CELL LUNG CARCINOMAS
Paginierung
1063 - 1068
Datum der Veröffentlichung
1992
Status
Published
Titel
EXPRESSION OF SEVERAL RESISTANCE MECHANISMS IN UNTREATED HUMAN KIDNEY AND LUNG CARCINOMAS
Sub types
  • Article
Ausgabe der Zeitschrift
12

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
Thirty human renal cell carcinomas and 94 non-small cell lung carcinomas of previously untreated patients were analyzed for the presence of P-glycoprotein, glutathione S-transferase-pi and topoisomerase II by means of immunohistochemistry. In the renal cell carcinomas investigated, two resistance markers were seen in 53% and three resistance markers in 36% of the cases. In only three tumors was one resistance mechanism observed. In the 94 non-small cell lung carcinomas 34% had two and 20% three resistance mechanisms, whereas 24% of the tumors revealed only one resistance mechanism. For determining the resistance of the tumors against drugs an in vitro short-term test was used. Only 12% of the sensitive lung tumors had more than one resistance mechanism, whereas 70% of the resistant tumors did. Thus a significant relationship exists between the resistance measured in vitro and the overexpression of P-glycoprotein or glutathione S-transferase-pi and the down-regulation of topoisomerase II.
Addresses
  • German Cancer Research Center, Heidelberg.
Autoren
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 1354430
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
Anticancer research
Schlüsselwörter
  • Humans
  • Carcinoma, Renal Cell
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Kidney Neoplasms
  • DNA Topoisomerases, Type II
  • Glutathione Transferase
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Drug Resistance
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
1063 - 1067
Datum der Veröffentlichung
1992
Status
Published
Datum der Datenerfassung
1992
Titel
Expression of several resistance mechanisms in untreated human kidney and lung carcinomas.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: Europe PubMed Central

Abstract
Thirty human renal cell carcinomas and 94 non-small cell lung carcinomas of previously untreated patients were analyzed for the presence of P-glycoprotein, glutathione S-transferase-pi and topoisomerase II by means of immunohistochemistry. In the renal cell carcinomas investigated, two resistance markers were seen in 53% and three resistance markers in 36% of the cases. In only three tumors was one resistance mechanism observed. In the 94 non-small cell lung carcinomas 34% had two and 20% three resistance mechanisms, whereas 24% of the tumors revealed only one resistance mechanism. For determining the resistance of the tumors against drugs an in vitro short-term test was used. Only 12% of the sensitive lung tumors had more than one resistance mechanism, whereas 70% of the resistant tumors did. Thus a significant relationship exists between the resistance measured in vitro and the overexpression of P-glycoprotein or glutathione S-transferase-pi and the down-regulation of topoisomerase II.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/1354430
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
Anticancer Res
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Renal Cell
  • DNA Topoisomerases, Type II
  • Drug Resistance
  • Glutathione Transferase
  • Humans
  • Kidney Neoplasms
  • Lung Neoplasms
  • Membrane Glycoproteins
  • Neoplasm Proteins
Sprache
eng
Country
Greece
Paginierung
1063 - 1067
Datum der Veröffentlichung
1992
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1992
Titel
Expression of several resistance mechanisms in untreated human kidney and lung carcinomas.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: PubMed

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