EXPRESSION OF RESISTANCE FACTORS (P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE-PI, AND TOPOISOMERASE-II) AND THEIR INTERRELATIONSHIP TO PROTOONCOGENE PRODUCTS IN RENAL-CELL CARCINOMAS

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1993LH25600030&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/1097-0142(19930615)71:12<3981::AID-CNCR2820711231>3.0.CO;2-A
Externe Identifier
  • Clarivate Analytics Document Solution ID: LH256
  • PubMed Identifier: 8099529
ISSN
0008-543X
Ausgabe der Veröffentlichung
12
Zeitschrift
CANCER
Schlüsselwörter
  • P-GLYCOPROTEIN
  • GLUTATHIONE S-TRANSFERASE
  • TOPOISOMERASE-II
  • PROTOONCOGENES
  • RENAL CELL CARCINOMAS
Paginierung
3981 - 3987
Datum der Veröffentlichung
1993
Status
Published
Titel
EXPRESSION OF RESISTANCE FACTORS (P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE-PI, AND TOPOISOMERASE-II) AND THEIR INTERRELATIONSHIP TO PROTOONCOGENE PRODUCTS IN RENAL-CELL CARCINOMAS
Sub types
  • Article
Ausgabe der Zeitschrift
71

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1002/1097-0142(19930615)71:12<3981::aid-cncr2820711231>3.0.co;2-a
eISSN
1097-0142
ISSN
0008-543X
Ausgabe der Veröffentlichung
12
Zeitschrift
Cancer
Sprache
en
Paginierung
3981 - 3987
Datum der Veröffentlichung
1993
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/1097-0142(19930615)71:12%3C3981::aid-cncr2820711231%3E3.0.co;2-a
Datum der Datenerfassung
2021
Titel
Expression of resistance factors (P-glycoprotein, glutathione S-transferase-π, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas
Ausgabe der Zeitschrift
71

Data source: Crossref

Abstract
<h4>Background</h4>This study investigates whether or not an interrelationship exists between the expression of resistance-related proteins (P-glycoprotein, glutathione S-transferase, topoisomerase II) and proto-oncogene products (c-fos, c-myc, c-K-ras, epidermal growth factor receptor [EGF-R], and c-neu proteins.)<h4>Methods</h4>Thirty-eight human renal cell carcinomas of previously untreated patients were analyzed for expression of P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi), topoisomerase II (Topo II) and proto-oncogene proteins by means of immunohistochemistry. Because of significant heterogeneity in most tumor biopsies, all analyses were done on tumor-derived primary cell culture lines on the third or fourth passage.<h4>Results</h4>An interrelationship between increased expression of P-170 and GST-pi and down-regulation of Topo II was found. Expression of the c-fos protein was seen in 66% of the tumors; expression of the c-myc protein, in 50%; of the c-K-ras protein, in 16%; of the EGF-R protein, in 61%; and of the c-neu protein, in 54% of the tumors. A significant correlation between the resistance factors and the c-fos, EGF-R, and c neu-proteins was observed (GST/c-fos, P = 0.012; Topo II/c-fos, P = 0.024; P-170/EGF-R, P < 0.001; GST/EGF-R, P = 0.018; Topo II/EGF-R, P = 0.027; P-170/c-neu, P = 0.005; GST/c-neu, P = 0.018; Topo II/EGF-R, P = 0.027; P-170/c-neu, P = 0.005; GST/c-neu, P = 0.008; Topo II/c-neu, P = 0.05). In contrast, interrelationships between resistance proteins and c-myc and c-K-ras proteins were not found. A significant interrelationship between the investigated resistance-related proteins or proto-oncogene proteins and the stage or grading of the tumors was not observed.<h4>Conclusions</h4>The results demonstrate that in renal cell carcinomas a significant relationship exists between resistance-related proteins, such as P-170, GST-pi, or Topo II, and proto-oncogenes, such as c-fos, c-erbB1, and c-neu.
Addresses
  • German Cancer Research Center, Heidelberg.
Autoren
DOI
10.1002/1097-0142(19930615)71:12<3981::aid-cncr2820711231>3.0.co;2-a
eISSN
1097-0142
Externe Identifier
  • PubMed Identifier: 8099529
Open access
false
ISSN
0008-543X
Ausgabe der Veröffentlichung
12
Zeitschrift
Cancer
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • DNA Topoisomerases, Type II
  • Glutathione Transferase
  • Receptor, erbB-2
  • Carrier Proteins
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-myc
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Immunoenzyme Techniques
  • Gene Expression Regulation, Neoplastic
  • Drug Resistance
  • Proto-Oncogene Proteins p21(ras)
  • Protein-Tyrosine Kinases
  • ErbB Receptors
  • Biomarkers, Tumor
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Proto-Oncogene Mas
Sprache
eng
Medium
Print
Paginierung
3981 - 3987
Datum der Veröffentlichung
1993
Status
Published
Datum der Datenerfassung
1993
Titel
Expression of resistance factors (P-glycoprotein, glutathione S-transferase-pi, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
71

Data source: Europe PubMed Central

Abstract
BACKGROUND: This study investigates whether or not an interrelationship exists between the expression of resistance-related proteins (P-glycoprotein, glutathione S-transferase, topoisomerase II) and proto-oncogene products (c-fos, c-myc, c-K-ras, epidermal growth factor receptor [EGF-R], and c-neu proteins.) METHODS: Thirty-eight human renal cell carcinomas of previously untreated patients were analyzed for expression of P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi), topoisomerase II (Topo II) and proto-oncogene proteins by means of immunohistochemistry. Because of significant heterogeneity in most tumor biopsies, all analyses were done on tumor-derived primary cell culture lines on the third or fourth passage. RESULTS: An interrelationship between increased expression of P-170 and GST-pi and down-regulation of Topo II was found. Expression of the c-fos protein was seen in 66% of the tumors; expression of the c-myc protein, in 50%; of the c-K-ras protein, in 16%; of the EGF-R protein, in 61%; and of the c-neu protein, in 54% of the tumors. A significant correlation between the resistance factors and the c-fos, EGF-R, and c neu-proteins was observed (GST/c-fos, P = 0.012; Topo II/c-fos, P = 0.024; P-170/EGF-R, P < 0.001; GST/EGF-R, P = 0.018; Topo II/EGF-R, P = 0.027; P-170/c-neu, P = 0.005; GST/c-neu, P = 0.018; Topo II/EGF-R, P = 0.027; P-170/c-neu, P = 0.005; GST/c-neu, P = 0.008; Topo II/c-neu, P = 0.05). In contrast, interrelationships between resistance proteins and c-myc and c-K-ras proteins were not found. A significant interrelationship between the investigated resistance-related proteins or proto-oncogene proteins and the stage or grading of the tumors was not observed. CONCLUSIONS: The results demonstrate that in renal cell carcinomas a significant relationship exists between resistance-related proteins, such as P-170, GST-pi, or Topo II, and proto-oncogenes, such as c-fos, c-erbB1, and c-neu.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/8099529
DOI
10.1002/1097-0142(19930615)71:12<3981::aid-cncr2820711231>3.0.co;2-a
ISSN
0008-543X
Ausgabe der Veröffentlichung
12
Zeitschrift
Cancer
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Biomarkers, Tumor
  • Carcinoma, Renal Cell
  • Carrier Proteins
  • DNA Topoisomerases, Type II
  • Drug Resistance
  • ErbB Receptors
  • Gene Expression Regulation, Neoplastic
  • Glutathione Transferase
  • Humans
  • Immunoenzyme Techniques
  • Kidney Neoplasms
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-myc
  • Proto-Oncogene Proteins p21(ras)
  • Receptor, ErbB-2
  • Receptors, Cell Surface
  • Tumor Cells, Cultured
Sprache
eng
Country
United States
Paginierung
3981 - 3987
Datum der Veröffentlichung
1993
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1993
Titel
Expression of resistance factors (P-glycoprotein, glutathione S-transferase-pi, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
71

Data source: PubMed

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