EXPRESSION OF PROTEIN-KINASE-C IN HUMAN RENAL-CELL CARCINOMA-CELLS WITH INHERENT RESISTANCE TO DOXORUBICIN
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- T EFFERTH
- M VOLM
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1992KP43000048&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: KP430
- PubMed Identifier: 1363517
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 6B
- Zeitschrift
- ANTICANCER RESEARCH
- Schlüsselwörter
- PROTEIN KINASE-C
- INHERENT DOXORUBICIN RESISTANCE
- P-GLYCOPROTEIN
- RENAL CELL CARCINOMA CELLS
- Paginierung
- 2209 - 2212
- Datum der Veröffentlichung
- 1992
- Status
- Published
- Titel
- EXPRESSION OF PROTEIN-KINASE-C IN HUMAN RENAL-CELL CARCINOMA-CELLS WITH INHERENT RESISTANCE TO DOXORUBICIN
- Sub types
- Article
- Ausgabe der Zeitschrift
- 12
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- The expression of protein kinase C (PKC) was analyzed in 18 primary cell cultures of human renal cell carcinomas by means of immunocytochemistry. We found that a high PKC expression significantly correlates with both resistance to doxorubicin and high P-glycoprotein expression. These data support the hypothesis that PKC is involved in inherent drug-resistance by phosphorylation and regulation of P-glycoprotein.
- Addresses
- German Cancer Research Center, Heidelberg.
- Autoren
- T Efferth
- M Volm
- eISSN
- 1791-7530
- Externe Identifier
- PubMed Identifier: 1363517
- Open access
- false
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 6B
- Zeitschrift
- Anticancer research
- Schlüsselwörter
- Cell Line
- Tumor Cells, Cultured
- Humans
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Doxorubicin
- Protein Kinase C
- Membrane Glycoproteins
- Antibodies, Monoclonal
- Drug Screening Assays, Antitumor
- Immunohistochemistry
- Cell Division
- Drug Resistance
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Paginierung
- 2209 - 2211
- Datum der Veröffentlichung
- 1992
- Status
- Published
- Datum der Datenerfassung
- 1992
- Titel
- Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin.
- Sub types
- Comparative Study
- Journal Article
- Ausgabe der Zeitschrift
- 12
Data source: Europe PubMed Central
- Abstract
- The expression of protein kinase C (PKC) was analyzed in 18 primary cell cultures of human renal cell carcinomas by means of immunocytochemistry. We found that a high PKC expression significantly correlates with both resistance to doxorubicin and high P-glycoprotein expression. These data support the hypothesis that PKC is involved in inherent drug-resistance by phosphorylation and regulation of P-glycoprotein.
- Autoren
- T Efferth
- M Volm
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/1363517
- ISSN
- 0250-7005
- Ausgabe der Veröffentlichung
- 6B
- Zeitschrift
- Anticancer Res
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibodies, Monoclonal
- Carcinoma, Renal Cell
- Cell Division
- Cell Line
- Doxorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Humans
- Immunohistochemistry
- Kidney Neoplasms
- Membrane Glycoproteins
- Protein Kinase C
- Tumor Cells, Cultured
- Sprache
- eng
- Country
- Greece
- Paginierung
- 2209 - 2211
- Datum der Veröffentlichung
- 1992
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1993
- Titel
- Expression of protein kinase C in human renal cell carcinoma cells with inherent resistance to doxorubicin.
- Sub types
- Comparative Study
- Journal Article
- Ausgabe der Zeitschrift
- 12
Data source: PubMed
- Beziehungen:
- Property of