MODULATION OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG-RESISTANCE BY MONOCLONAL-ANTIBODIES, IMMUNOTOXINS OR ANTISENSE OLIGODEOXYNUCLEOTIDES IN KIDNEY CARCINOMA AND NORMAL KIDNEY-CELLS

Publication type:
Journal article
Metadata:
Autoren
  • T EFFERTH
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1993LJ04300023&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: LJ043
  • PubMed Identifier: 8098865
ISSN
0030-2414
Ausgabe der Veröffentlichung
4
Zeitschrift
ONCOLOGY
Schlüsselwörter
  • P-GLYCOPROTEIN
  • MULTIDRUG-RESISTANCE
  • MONOCLONAL ANTIBODIES
  • IMMUNOTOXINS
  • ANTISENSE OLIGODEOXYNUCLEOTIDES
Paginierung
303 - 308
Datum der Veröffentlichung
1993
Status
Published
Titel
MODULATION OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG-RESISTANCE BY MONOCLONAL-ANTIBODIES, IMMUNOTOXINS OR ANTISENSE OLIGODEOXYNUCLEOTIDES IN KIDNEY CARCINOMA AND NORMAL KIDNEY-CELLS
Sub types
  • Article
Ausgabe der Zeitschrift
50

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • T Efferth
  • M Volm
DOI
10.1159/000227200
eISSN
1423-0232
ISSN
0030-2414
Ausgabe der Veröffentlichung
4
Zeitschrift
Oncology
Sprache
en
Online publication date
2009
Paginierung
303 - 308
Datum der Veröffentlichung
1993
Status
Published
Herausgeber
S. Karger AG
Herausgeber URL
http://dx.doi.org/10.1159/000227200
Datum der Datenerfassung
2017
Titel
Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Monoclonal Antibodies, Immunotoxins or Antisense Oligodeoxynucleotides in Kidney Carcinoma and Normal Kidney Cells
Ausgabe der Zeitschrift
50

Data source: Crossref

Abstract
In the present investigation we show that both monoclonal antibodies against P-170 (265/F4, MRK 16, and HYB 612) and 265/F4-ricin alpha-chain immunotoxin are useful tools for the eradication of kidney carcinoma and normal kidney primary cell cultures with high P-170 expression, whereas kidney tumor and normal kidney cell lines with low amounts of P-170 are less affected. Furthermore, we found that the expression of P-170 in both kidney tumor and normal kidney cell cultures with high amounts of P-170 was inhibited by antisense oligodeoxynucleotides complementary to base pairs -9 to +6 of the MDR1 gene. These data indicate that these approaches for the eradication of P-170 expressing multidrug-resistant cells are not limited to tumors but also affect P-170 expressing normal cells.
Addresses
  • German Cancer Research Centre, Heidelberg.
Autoren
DOI
10.1159/000227200
eISSN
1423-0232
Externe Identifier
  • PubMed Identifier: 8098865
Open access
false
ISSN
0030-2414
Ausgabe der Veröffentlichung
4
Zeitschrift
Oncology
Schlüsselwörter
  • Kidney
  • Cells, Cultured
  • Tumor Cells, Cultured
  • Humans
  • Kidney Neoplasms
  • Carrier Proteins
  • Membrane Glycoproteins
  • Oligonucleotides, Antisense
  • Immunotoxins
  • Antibodies, Monoclonal
  • Cell Division
  • Base Sequence
  • Drug Resistance
  • Molecular Sequence Data
  • Adult
  • Middle Aged
  • Female
  • Male
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
303 - 308
Datum der Veröffentlichung
1993
Status
Published
Datum der Datenerfassung
1993
Titel
Modulation of P-glycoprotein-mediated multidrug resistance by monoclonal antibodies, immunotoxins or antisense oligodeoxynucleotides in kidney carcinoma and normal kidney cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
50

Data source: Europe PubMed Central

Abstract
In the present investigation we show that both monoclonal antibodies against P-170 (265/F4, MRK 16, and HYB 612) and 265/F4-ricin alpha-chain immunotoxin are useful tools for the eradication of kidney carcinoma and normal kidney primary cell cultures with high P-170 expression, whereas kidney tumor and normal kidney cell lines with low amounts of P-170 are less affected. Furthermore, we found that the expression of P-170 in both kidney tumor and normal kidney cell cultures with high amounts of P-170 was inhibited by antisense oligodeoxynucleotides complementary to base pairs -9 to +6 of the MDR1 gene. These data indicate that these approaches for the eradication of P-170 expressing multidrug-resistant cells are not limited to tumors but also affect P-170 expressing normal cells.
Autoren
  • T Efferth
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/8098865
DOI
10.1159/000227200
ISSN
0030-2414
Ausgabe der Veröffentlichung
4
Zeitschrift
Oncology
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Adult
  • Antibodies, Monoclonal
  • Base Sequence
  • Carrier Proteins
  • Cell Division
  • Cells, Cultured
  • Drug Resistance
  • Female
  • Humans
  • Immunotoxins
  • Kidney
  • Kidney Neoplasms
  • Male
  • Membrane Glycoproteins
  • Middle Aged
  • Molecular Sequence Data
  • Oligonucleotides, Antisense
  • Tumor Cells, Cultured
Sprache
eng
Country
Switzerland
Paginierung
303 - 308
Datum der Veröffentlichung
1993
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1993
Titel
Modulation of P-glycoprotein-mediated multidrug resistance by monoclonal antibodies, immunotoxins or antisense oligodeoxynucleotides in kidney carcinoma and normal kidney cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
50

Data source: PubMed

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