INCREASE OF ALKALINE-PHOSPHATASE IN MULTIDRUG-RESISTANT TUMOR-CELLS AND THEIR CROSS-RESISTANCE TO 6-THIOGUANINE
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- T EFFERTH
- M VOLM
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1993ME38000019&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: ME380
- PubMed Identifier: 8267680
- ISSN
- 0004-4172
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
- Schlüsselwörter
- ALKALINE PHOSPHATASE
- CARCINOMA, LUNG, RENAL CELL
- CAS-154-42-7
- MULTIDRUG RESISTANCE
- 6-THIOGUANINE RESISTANCE
- Paginierung
- 1118 - 1121
- Datum der Veröffentlichung
- 1993
- Status
- Published
- Titel
- INCREASE OF ALKALINE-PHOSPHATASE IN MULTIDRUG-RESISTANT TUMOR-CELLS AND THEIR CROSS-RESISTANCE TO 6-THIOGUANINE
- Sub types
- Article
- Ausgabe der Zeitschrift
- 43-2
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- The expression of alkaline phosphatase (AP) was analyzed in multidrug-resistant (MDR) tumor cells (sarcoma 180, lung carcinoma, and renal cell carcinoma cell lines) by means of immunocytochemistry. MDR cell cultures showed an overexpression of AP and a cross-resistance to 6-thioguanine (6-TG, CAS 154-42-7). Significant correlations between AP expression and doxorubicin or vincristine resistance and P-glycoprotein (P-170) expression were found in these cell cultures. A specific AP inhibitor, levamisole, reversed resistance to 6-TG, but not to doxorubicin. This indicates that 6-TG resistance is certainly associated to P-170 but a causal function of AP for the development of MDR does not exist.
- Addresses
- German Cancer Research Center, Heidelberg.
- Autoren
- T Efferth
- M Volm
- eISSN
- 1616-7066
- Externe Identifier
- PubMed Identifier: 8267680
- Open access
- false
- ISSN
- 0004-4172
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Arzneimittel-Forschung
- Schlüsselwörter
- Tumor Cells, Cultured
- Animals
- Humans
- Mice
- Sarcoma 180
- Carcinoma, Renal Cell
- Vincristine
- Levamisole
- Thioguanine
- Doxorubicin
- Alkaline Phosphatase
- Antineoplastic Agents
- Radioimmunoassay
- Immunohistochemistry
- Cell Division
- Drug Resistance
- Sprache
- eng
- Medium
- Paginierung
- 1118 - 1121
- Datum der Veröffentlichung
- 1993
- Status
- Published
- Datum der Datenerfassung
- 1993
- Titel
- Increase of alkaline phosphatase in multidrug-resistant tumor cells and their cross-resistance to 6-thioguanine.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 43
Data source: Europe PubMed Central
- Abstract
- The expression of alkaline phosphatase (AP) was analyzed in multidrug-resistant (MDR) tumor cells (sarcoma 180, lung carcinoma, and renal cell carcinoma cell lines) by means of immunocytochemistry. MDR cell cultures showed an overexpression of AP and a cross-resistance to 6-thioguanine (6-TG, CAS 154-42-7). Significant correlations between AP expression and doxorubicin or vincristine resistance and P-glycoprotein (P-170) expression were found in these cell cultures. A specific AP inhibitor, levamisole, reversed resistance to 6-TG, but not to doxorubicin. This indicates that 6-TG resistance is certainly associated to P-170 but a causal function of AP for the development of MDR does not exist.
- Autoren
- T Efferth
- M Volm
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/8267680
- ISSN
- 0004-4172
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Arzneimittelforschung
- Schlüsselwörter
- Alkaline Phosphatase
- Animals
- Antineoplastic Agents
- Carcinoma, Renal Cell
- Cell Division
- Doxorubicin
- Drug Resistance
- Humans
- Immunohistochemistry
- Levamisole
- Mice
- Radioimmunoassay
- Sarcoma 180
- Thioguanine
- Tumor Cells, Cultured
- Vincristine
- Sprache
- eng
- Country
- Germany
- Paginierung
- 1118 - 1121
- Datum der Veröffentlichung
- 1993
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1994
- Titel
- Increase of alkaline phosphatase in multidrug-resistant tumor cells and their cross-resistance to 6-thioguanine.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 43
Data source: PubMed
- Beziehungen:
- Property of