INTRINSIC OVEREXPRESSION OF 2 DIFFERENT MECHANISMS OF RESISTANCE TO CHEMOTHERAPY (P-GLYCOPROTEIN AND GST-PI) IN HUMAN ENDOMETRIAL CARCINOMA
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- J SCHNEIDER
- T EFFERTH
- FJ RODRIGUEZESCUDERO
- M VOLM
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1994NQ63600008&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1159/000239203
- Externe Identifier
- Clarivate Analytics Document Solution ID: NQ636
- PubMed Identifier: 7915981
- ISSN
- 0009-3157
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- CHEMOTHERAPY
- Schlüsselwörter
- CHEMOTHERAPY
- RESISTANCE
- P-GLYCOPROTEIN
- GLUTATHIONE-S-TRANSFERASE
- ENDOMETRIUM
- CARCINOMA
- Paginierung
- 265 - 271
- Datum der Veröffentlichung
- 1994
- Status
- Published
- Titel
- INTRINSIC OVEREXPRESSION OF 2 DIFFERENT MECHANISMS OF RESISTANCE TO CHEMOTHERAPY (P-GLYCOPROTEIN AND GST-PI) IN HUMAN ENDOMETRIAL CARCINOMA
- Sub types
- Article
- Ausgabe der Zeitschrift
- 40
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- J Schneider
- T Efferth
- FJ Rodriguez-Escudero
- M Volm
- DOI
- 10.1159/000239203
- eISSN
- 1421-9794
- ISSN
- 0009-3157
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Chemotherapy
- Sprache
- en
- Online publication date
- 2009
- Paginierung
- 265 - 271
- Datum der Veröffentlichung
- 1994
- Status
- Published
- Herausgeber
- S. Karger AG
- Herausgeber URL
- http://dx.doi.org/10.1159/000239203
- Datum der Datenerfassung
- 2017
- Titel
- Intrinsic Overexpression of Two Different Mechanisms of Resistance to Chemotherapy (P-Glycoprotein and GST-π) in Human Endometrial Carcinoma
- Ausgabe der Zeitschrift
- 40
Data source: Crossref
- Abstract
- Endometrial carcinoma is considered a tumor which does not respond well to chemotherapeutic treatment. Among the various mechanisms of resistance to chemotherapy which are under investigation, two of them (multidrug resistance, mediated by P-glycoprotein, and glutathione-S-transferase-pi [GST-pi] overexpression) are of great interest for gynecologic oncologists, because they involve several drugs commonly used in practice, among which Adriamycin and cisplatin are probably the most important ones. We have studied 23 human endometrial carcinomas of different histological varieties and 3 normal endometrial samples for the overexpression of both P-glycoprotein and GST-pi by means of immunohistochemistry. Both resistance markers were detectable in all tumor samples, and in normal endometrial tissue as well. The concomitant intrinsic overexpression of these two resistance mechanisms may in part explain why these tumors tend to be extremely resistant to chemotherapy.
- Addresses
- Gynecologic Oncology Service, Hospital de Cruces, Universidad del Pais Vasco, Bilbao, Spain.
- Autoren
- J Schneider
- T Efferth
- T Efferth
- FJ Rodriguez-Escudero
- M Volm
- DOI
- 10.1159/000239203
- eISSN
- 1421-9794
- Externe Identifier
- PubMed Identifier: 7915981
- Open access
- false
- ISSN
- 0009-3157
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Chemotherapy
- Schlüsselwörter
- Humans
- Adenocarcinoma
- Endometrial Neoplasms
- Cisplatin
- Glutathione Transferase
- Carrier Proteins
- Membrane Glycoproteins
- Neoplasm Proteins
- Immunohistochemistry
- Drug Resistance
- Female
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Sprache
- eng
- Medium
- Paginierung
- 265 - 271
- Datum der Veröffentlichung
- 1994
- Status
- Published
- Datum der Datenerfassung
- 1994
- Titel
- Intrinsic overexpression of two different mechanisms of resistance to chemotherapy (P-glycoprotein and GST-pi) in human endometrial carcinoma.
- Sub types
- Comparative Study
- Journal Article
- Ausgabe der Zeitschrift
- 40
Data source: Europe PubMed Central
- Abstract
- Endometrial carcinoma is considered a tumor which does not respond well to chemotherapeutic treatment. Among the various mechanisms of resistance to chemotherapy which are under investigation, two of them (multidrug resistance, mediated by P-glycoprotein, and glutathione-S-transferase-pi [GST-pi] overexpression) are of great interest for gynecologic oncologists, because they involve several drugs commonly used in practice, among which Adriamycin and cisplatin are probably the most important ones. We have studied 23 human endometrial carcinomas of different histological varieties and 3 normal endometrial samples for the overexpression of both P-glycoprotein and GST-pi by means of immunohistochemistry. Both resistance markers were detectable in all tumor samples, and in normal endometrial tissue as well. The concomitant intrinsic overexpression of these two resistance mechanisms may in part explain why these tumors tend to be extremely resistant to chemotherapy.
- Autoren
- J Schneider
- T Efferth
- FJ Rodriguez-Escudero
- M Volm
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/7915981
- DOI
- 10.1159/000239203
- ISSN
- 0009-3157
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Chemotherapy
- Schlüsselwörter
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenocarcinoma
- Carrier Proteins
- Cisplatin
- Drug Resistance
- Endometrial Neoplasms
- Female
- Glutathione Transferase
- Humans
- Immunohistochemistry
- Membrane Glycoproteins
- Neoplasm Proteins
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 265 - 271
- Datum der Veröffentlichung
- 1994
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1994
- Titel
- Intrinsic overexpression of two different mechanisms of resistance to chemotherapy (P-glycoprotein and GST-pi) in human endometrial carcinoma.
- Sub types
- Comparative Study
- Journal Article
- Ausgabe der Zeitschrift
- 40
Data source: PubMed
- Beziehungen:
- Property of