INTRINSIC OVEREXPRESSION OF 2 DIFFERENT MECHANISMS OF RESISTANCE TO CHEMOTHERAPY (P-GLYCOPROTEIN AND GST-PI) IN HUMAN ENDOMETRIAL CARCINOMA

Publication type:
Journal article
Metadata:
Autoren
  • J SCHNEIDER
  • T EFFERTH
  • FJ RODRIGUEZESCUDERO
  • M VOLM
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1994NQ63600008&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1159/000239203
Externe Identifier
  • Clarivate Analytics Document Solution ID: NQ636
  • PubMed Identifier: 7915981
ISSN
0009-3157
Ausgabe der Veröffentlichung
4
Zeitschrift
CHEMOTHERAPY
Schlüsselwörter
  • CHEMOTHERAPY
  • RESISTANCE
  • P-GLYCOPROTEIN
  • GLUTATHIONE-S-TRANSFERASE
  • ENDOMETRIUM
  • CARCINOMA
Paginierung
265 - 271
Datum der Veröffentlichung
1994
Status
Published
Titel
INTRINSIC OVEREXPRESSION OF 2 DIFFERENT MECHANISMS OF RESISTANCE TO CHEMOTHERAPY (P-GLYCOPROTEIN AND GST-PI) IN HUMAN ENDOMETRIAL CARCINOMA
Sub types
  • Article
Ausgabe der Zeitschrift
40

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • J Schneider
  • T Efferth
  • FJ Rodriguez-Escudero
  • M Volm
DOI
10.1159/000239203
eISSN
1421-9794
ISSN
0009-3157
Ausgabe der Veröffentlichung
4
Zeitschrift
Chemotherapy
Sprache
en
Online publication date
2009
Paginierung
265 - 271
Datum der Veröffentlichung
1994
Status
Published
Herausgeber
S. Karger AG
Herausgeber URL
http://dx.doi.org/10.1159/000239203
Datum der Datenerfassung
2024
Titel
Intrinsic Overexpression of Two Different Mechanisms of Resistance to Chemotherapy (P-Glycoprotein and GST-π) in Human Endometrial Carcinoma
Ausgabe der Zeitschrift
40

Data source: Crossref

Abstract
Endometrial carcinoma is considered a tumor which does not respond well to chemotherapeutic treatment. Among the various mechanisms of resistance to chemotherapy which are under investigation, two of them (multidrug resistance, mediated by P-glycoprotein, and glutathione-S-transferase-pi [GST-pi] overexpression) are of great interest for gynecologic oncologists, because they involve several drugs commonly used in practice, among which Adriamycin and cisplatin are probably the most important ones. We have studied 23 human endometrial carcinomas of different histological varieties and 3 normal endometrial samples for the overexpression of both P-glycoprotein and GST-pi by means of immunohistochemistry. Both resistance markers were detectable in all tumor samples, and in normal endometrial tissue as well. The concomitant intrinsic overexpression of these two resistance mechanisms may in part explain why these tumors tend to be extremely resistant to chemotherapy.
Addresses
  • Gynecologic Oncology Service, Hospital de Cruces, Universidad del Pais Vasco, Bilbao, Spain.
Autoren
  • J Schneider
  • T Efferth
  • T Efferth
  • FJ Rodriguez-Escudero
  • M Volm
DOI
10.1159/000239203
eISSN
1421-9794
Externe Identifier
  • PubMed Identifier: 7915981
Open access
false
ISSN
0009-3157
Ausgabe der Veröffentlichung
4
Zeitschrift
Chemotherapy
Schlüsselwörter
  • Humans
  • Adenocarcinoma
  • Endometrial Neoplasms
  • Cisplatin
  • Glutathione Transferase
  • Carrier Proteins
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Immunohistochemistry
  • Drug Resistance
  • Female
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
265 - 271
Datum der Veröffentlichung
1994
Status
Published
Datum der Datenerfassung
1994
Titel
Intrinsic overexpression of two different mechanisms of resistance to chemotherapy (P-glycoprotein and GST-pi) in human endometrial carcinoma.
Sub types
  • Comparative Study
  • Journal Article
Ausgabe der Zeitschrift
40

Data source: Europe PubMed Central

Abstract
Endometrial carcinoma is considered a tumor which does not respond well to chemotherapeutic treatment. Among the various mechanisms of resistance to chemotherapy which are under investigation, two of them (multidrug resistance, mediated by P-glycoprotein, and glutathione-S-transferase-pi [GST-pi] overexpression) are of great interest for gynecologic oncologists, because they involve several drugs commonly used in practice, among which Adriamycin and cisplatin are probably the most important ones. We have studied 23 human endometrial carcinomas of different histological varieties and 3 normal endometrial samples for the overexpression of both P-glycoprotein and GST-pi by means of immunohistochemistry. Both resistance markers were detectable in all tumor samples, and in normal endometrial tissue as well. The concomitant intrinsic overexpression of these two resistance mechanisms may in part explain why these tumors tend to be extremely resistant to chemotherapy.
Autoren
  • J Schneider
  • T Efferth
  • FJ Rodriguez-Escudero
  • M Volm
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/7915981
DOI
10.1159/000239203
ISSN
0009-3157
Ausgabe der Veröffentlichung
4
Zeitschrift
Chemotherapy
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Adenocarcinoma
  • Carrier Proteins
  • Cisplatin
  • Drug Resistance
  • Endometrial Neoplasms
  • Female
  • Glutathione Transferase
  • Humans
  • Immunohistochemistry
  • Membrane Glycoproteins
  • Neoplasm Proteins
Sprache
eng
Country
Switzerland
Paginierung
265 - 271
Datum der Veröffentlichung
1994
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1994
Titel
Intrinsic overexpression of two different mechanisms of resistance to chemotherapy (P-glycoprotein and GST-pi) in human endometrial carcinoma.
Sub types
  • Comparative Study
  • Journal Article
Ausgabe der Zeitschrift
40

Data source: PubMed

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