INCREASED INDUCTION OF APOPTOSIS IN MONONUCLEAR-CELLS OF A GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENT PATIENT
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- T EFFERTH
- U FABRY
- P GLATTE
- R OSIEKA
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1995QJ06400008&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1007/BF00203619
- Externe Identifier
- Clarivate Analytics Document Solution ID: QJ064
- PubMed Identifier: 7633942
- ISSN
- 0946-2716
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- JOURNAL OF MOLECULAR MEDICINE-JMM
- Schlüsselwörter
- GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY
- APOPTOSIS
- GLUTATHIONE
- P-GLYCOPROTEIN
- FLOW CYTOMETRY
- Paginierung
- 47 - 49
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Titel
- INCREASED INDUCTION OF APOPTOSIS IN MONONUCLEAR-CELLS OF A GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENT PATIENT
- Sub types
- Note
- Ausgabe der Zeitschrift
- 73
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- T Efferth
- U Fabry
- P Glatte
- R Osieka
- DOI
- 10.1007/bf00203619
- eISSN
- 1432-1440
- ISSN
- 0946-2716
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Journal of Molecular Medicine
- Sprache
- en
- Online publication date
- 1995
- Paginierung
- 47 - 49
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/bf00203619
- Datum der Datenerfassung
- 2020
- Titel
- Increased induction of apoptosis in mononuclear cells of a glucose-6-phosphate dehydrogenase deficient patient
- Ausgabe der Zeitschrift
- 73
Data source: Crossref
- Abstract
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency belongs to the most common human disorders of metabolism. In affected patients generation of free radicals causes life-threatening hemolytic crises, for example, after consumption of certain drugs and foods or after infections. Rather than erythrocytes we analyzed mononuclear white blood cells of a patient suffering from G6PD deficiency with respect to their ability to enter apoptosis after treatment with daunorubicin, ionizing radiation, or dexamethasone. The induction of apoptosis was increased in G6PD-deficient cells compared to cells from eight normal donors. In parallel, the glutathione content of mononuclear cells from the G6PD-deficient patient was significantly decreased. While in affected patients decreased life span of erythrocytes damaged by oxidative stress has long been recognized as the mechanism underlying hemolysis, peripheral leukocytes have not received similar attention. Induction of apoptosis is a relatively complex process that has been linked to cellular glutathione content. This is the first report investigating G6PD deficiency and apoptosis.
- Addresses
- Medizinische Klinik IV, RWTH Aachen, Germany.
- Autoren
- T Efferth
- T Efferth
- U Fabry
- P Glatte
- R Osieka
- DOI
- 10.1007/bf00203619
- eISSN
- 1432-1440
- Externe Identifier
- PubMed Identifier: 7633942
- Open access
- false
- ISSN
- 0946-2716
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Journal of molecular medicine (Berlin, Germany)
- Schlüsselwörter
- Leukocytes, Mononuclear
- Humans
- Glucosephosphate Dehydrogenase Deficiency
- Daunorubicin
- Dexamethasone
- Glutathione
- DNA
- Flow Cytometry
- Apoptosis
- Radiation, Ionizing
- Adult
- Sprache
- eng
- Medium
- Paginierung
- 47 - 49
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Datum der Datenerfassung
- 1995
- Titel
- Increased induction of apoptosis in mononuclear cells of a glucose-6-phosphate dehydrogenase deficient patient.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Case Reports
- Ausgabe der Zeitschrift
- 73
Data source: Europe PubMed Central
- Abstract
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency belongs to the most common human disorders of metabolism. In affected patients generation of free radicals causes life-threatening hemolytic crises, for example, after consumption of certain drugs and foods or after infections. Rather than erythrocytes we analyzed mononuclear white blood cells of a patient suffering from G6PD deficiency with respect to their ability to enter apoptosis after treatment with daunorubicin, ionizing radiation, or dexamethasone. The induction of apoptosis was increased in G6PD-deficient cells compared to cells from eight normal donors. In parallel, the glutathione content of mononuclear cells from the G6PD-deficient patient was significantly decreased. While in affected patients decreased life span of erythrocytes damaged by oxidative stress has long been recognized as the mechanism underlying hemolysis, peripheral leukocytes have not received similar attention. Induction of apoptosis is a relatively complex process that has been linked to cellular glutathione content. This is the first report investigating G6PD deficiency and apoptosis.
- Autoren
- T Efferth
- U Fabry
- P Glatte
- R Osieka
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/7633942
- DOI
- 10.1007/BF00203619
- ISSN
- 0946-2716
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- J Mol Med (Berl)
- Schlüsselwörter
- Adult
- Apoptosis
- DNA
- Daunorubicin
- Dexamethasone
- Flow Cytometry
- Glucosephosphate Dehydrogenase Deficiency
- Glutathione
- Humans
- Leukocytes, Mononuclear
- Radiation, Ionizing
- Sprache
- eng
- Country
- Germany
- Paginierung
- 47 - 49
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 1995
- Titel
- Increased induction of apoptosis in mononuclear cells of a glucose-6-phosphate dehydrogenase deficient patient.
- Sub types
- Case Reports
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 73
Data source: PubMed
- Beziehungen:
- Property of