INDUCTION OF P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE-PI, CATALASE, C-FOS AND C-ERBB1 IN RODENT CELL-LINES AFTER EXPOSURE TO DOXORUBICIN, ETHANOL AND CAFFEINE
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- M VOLM
- T EFFERTH
- P GRABNER
- EW POMMERENKE
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1995PY33500014&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: PY335
- PubMed Identifier: 21556506
- ISSN
- 1019-6439
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- INTERNATIONAL JOURNAL OF ONCOLOGY
- Schlüsselwörter
- P-GLYCOPROTEIN
- GLUTATHIONE S-TRANSFERASE-PI
- CATALASE
- C-FOS
- C-ERBB1
- RODENT CELL LINES
- INDUCTION
- DOXORUBICIN
- ETHANOL
- CAFFEINE
- Paginierung
- 87 - 92
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Titel
- INDUCTION OF P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE-PI, CATALASE, C-FOS AND C-ERBB1 IN RODENT CELL-LINES AFTER EXPOSURE TO DOXORUBICIN, ETHANOL AND CAFFEINE
- Sub types
- Article
- Ausgabe der Zeitschrift
- 6
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- M VOLM
- T EFFERTH
- P GRABNER
- EW POMMERENKE
- DOI
- 10.3892/ijo.6.1.87
- eISSN
- 1791-2423
- ISSN
- 1019-6439
- Zeitschrift
- International Journal of Oncology
- Online publication date
- 1995
- Status
- Published online
- Herausgeber
- Spandidos Publications
- Herausgeber URL
- http://dx.doi.org/10.3892/ijo.6.1.87
- Datum der Datenerfassung
- 2017
- Titel
- INDUCTION OF P-GLYCOPROTEIN, GLUTATHIONE-S-TRANSFERASE-PI, CATALASE, C-FOS AND C-ERBB1 IN RODENT CELL-LINES AFTER EXPOSURE TO DOXORUBICIN, ETHANOL AND CAFFEINE
Data source: Crossref
- Abstract
- Murine NIH-3T3 cells were exposed to doxorubicin (DOX, 1 mu g/ml), ethanol (EtOH, 0.2%) and caffeine (CAFF, 200 mu g/ml) and analyzed for the induction of resistance proteins (P-glycoprotein, glutathione S-transferase-pi, catalase) and oncoproteins (c-EOS, c-ERBB1). P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi) and catalase (CAT) levels were found to be elevated after exposure of the cells to doxorubicin. In EtOH-treated cells the P-170 level was moderately increased (12 to 36 h after exposure), whereas the GST-pi and CAT levels were greatly increased (1 to 48 h). CAFF caused a moderate increase of P-170 (12 to 36 h) and of GST-pi (6 to 72 h). The accumulation of rhodamine 123 was reduced after the level of the resistance proteins had risen. After exposure to DOX, c-FOS was expressed moderately whereas c-ERBB1 was expressed strongly. Both oncoproteins showed a significant increase after exposure to EtOH. Only a moderate increase of c-FOS was seen after exposure to CAFF. Five out of seven additionally investigated rodent cell lines showed an increase in the expression of P-170, GST-pi and c-FOS after exposure to DOX, EtOH or CAFF.
- Autoren
- M Volm
- T Efferth
- P Grabner
- E Pommerenke
- DOI
- 10.3892/ijo.6.1.87
- eISSN
- 1791-2423
- Externe Identifier
- PubMed Identifier: 21556506
- Open access
- false
- ISSN
- 1019-6439
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- International journal of oncology
- Sprache
- eng
- Medium
- Paginierung
- 87 - 92
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Induction of p-glycoprotein, glutathione-s-transferase-pi, catalase, C-fos and C-erbb1 in rodent cell-lines after exposure to Doxorubicin, ethanol and caffeine.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 6
Data source: Europe PubMed Central
- Abstract
- Murine NIH-3T3 cells were exposed to doxorubicin (DOX, 1 mu g/ml), ethanol (EtOH, 0.2%) and caffeine (CAFF, 200 mu g/ml) and analyzed for the induction of resistance proteins (P-glycoprotein, glutathione S-transferase-pi, catalase) and oncoproteins (c-EOS, c-ERBB1). P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi) and catalase (CAT) levels were found to be elevated after exposure of the cells to doxorubicin. In EtOH-treated cells the P-170 level was moderately increased (12 to 36 h after exposure), whereas the GST-pi and CAT levels were greatly increased (1 to 48 h). CAFF caused a moderate increase of P-170 (12 to 36 h) and of GST-pi (6 to 72 h). The accumulation of rhodamine 123 was reduced after the level of the resistance proteins had risen. After exposure to DOX, c-FOS was expressed moderately whereas c-ERBB1 was expressed strongly. Both oncoproteins showed a significant increase after exposure to EtOH. Only a moderate increase of c-FOS was seen after exposure to CAFF. Five out of seven additionally investigated rodent cell lines showed an increase in the expression of P-170, GST-pi and c-FOS after exposure to DOX, EtOH or CAFF.
- Autoren
- M Volm
- T Efferth
- P Grabner
- E Pommerenke
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21556506
- DOI
- 10.3892/ijo.6.1.87
- ISSN
- 1019-6439
- Ausgabe der Veröffentlichung
- 1
- Zeitschrift
- Int J Oncol
- Sprache
- eng
- Country
- Greece
- Paginierung
- 87 - 92
- Datum der Veröffentlichung
- 1995
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Induction of p-glycoprotein, glutathione-s-transferase-pi, catalase, C-fos and C-erbb1 in rodent cell-lines after exposure to Doxorubicin, ethanol and caffeine.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 6
Data source: PubMed
- Beziehungen:
- Property of