Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs

Publication type:
Journal article
Metadata:
Autoren
  • T Efferth
  • G Rucker
  • M Falkenberg
  • D Manns
  • A Olbrich
  • U Fabry
  • R Osieka
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:A1996TY31800017&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: TY318
  • PubMed Identifier: 8720313
ISSN
0004-4172
Ausgabe der Veröffentlichung
2
Zeitschrift
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
Schlüsselwörter
  • apoptosis
  • artesunate
  • p-benzoquinone
  • miconidine acetate
  • primine
Paginierung
196 - 200
Datum der Veröffentlichung
1996
Status
Published
Titel
Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs
Sub types
  • Article
Ausgabe der Zeitschrift
46

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
Four investigational drugs, p-benzoquinone, primine, miconidine acetate, and artesunate (dihydroqinghaosusuccinate), with growth inhibitory activity against flagellatae (e.g. trypanosoma, leptomonas, plasmodium) were investigated for their capability to induce programmed cell death (apoptosis) in human KG-1a leukemic cells. The results were compared with those of three well established cytostatic agents (cisplatin, daunorubicin, cytosine-arabinoside) and ionizing radiation. The antitumor activity of the drugs was validated by a cellular growth inhibition assay. The depletion of glutathione by these four investigational drugs favours the hypothesis that formation of free radicals and subsequent DNA strand breaks may be critical mechanisms of action and that the glutathione redox cycle is involved in detoxification of these reactive molecules.
Addresses
  • Medizinische Klinik IV, Rheinisch-Westfälische Technische Hochschule Aachen, Germany.
Autoren
  • T Efferth
  • G Rücker
  • M Falkenberg
  • D Manns
  • A Olbrich
  • U Fabry
  • R Osieka
eISSN
1616-7066
Externe Identifier
  • PubMed Identifier: 8720313
Open access
false
ISSN
0004-4172
Ausgabe der Veröffentlichung
2
Zeitschrift
Arzneimittel-Forschung
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Leukemia, Experimental
  • DNA Damage
  • Glutathione
  • DNA, Neoplasm
  • Antineoplastic Agents
  • Drugs, Investigational
  • Apoptosis
  • Leukemia, Myeloid, Acute
Sprache
eng
Medium
Print
Paginierung
196 - 200
Datum der Veröffentlichung
1996
Status
Published
Datum der Datenerfassung
1996
Titel
Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
46

Data source: Europe PubMed Central

Abstract
Four investigational drugs, p-benzoquinone, primine, miconidine acetate, and artesunate (dihydroqinghaosusuccinate), with growth inhibitory activity against flagellatae (e.g. trypanosoma, leptomonas, plasmodium) were investigated for their capability to induce programmed cell death (apoptosis) in human KG-1a leukemic cells. The results were compared with those of three well established cytostatic agents (cisplatin, daunorubicin, cytosine-arabinoside) and ionizing radiation. The antitumor activity of the drugs was validated by a cellular growth inhibition assay. The depletion of glutathione by these four investigational drugs favours the hypothesis that formation of free radicals and subsequent DNA strand breaks may be critical mechanisms of action and that the glutathione redox cycle is involved in detoxification of these reactive molecules.
Autoren
  • T Efferth
  • G Rücker
  • M Falkenberg
  • D Manns
  • A Olbrich
  • U Fabry
  • R Osieka
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/8720313
ISSN
0004-4172
Ausgabe der Veröffentlichung
2
Zeitschrift
Arzneimittelforschung
Schlüsselwörter
  • Antineoplastic Agents
  • Apoptosis
  • DNA Damage
  • DNA, Neoplasm
  • Drugs, Investigational
  • Glutathione
  • Humans
  • Leukemia, Experimental
  • Leukemia, Myeloid, Acute
  • Tumor Cells, Cultured
Sprache
eng
Country
Germany
Paginierung
196 - 200
Datum der Veröffentlichung
1996
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
1997
Titel
Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
46

Data source: PubMed

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