Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma:: Gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- B Gunawan
- W Huber
- M Holtrup
- A von Heydebreck
- T Efferth
- A Poustka
- RH Ringert
- G Jakse
- L Füzesi
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000172013500006&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: 489VQ
- PubMed Identifier: 11691785
- ISSN
- 0008-5472
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- CANCER RESEARCH
- Paginierung
- 7731 - 7738
- Datum der Veröffentlichung
- 2001
- Status
- Published
- Titel
- Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma:: Gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis
- Sub types
- Article
- Ausgabe der Zeitschrift
- 61
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- To evaluate the prognostic significance of cytogenetic findings in clear cell renal cell carcinoma (RCC), cytogenetic results of 118 primary RCCs were evaluated in relation to classical indicators of prognosis and overall survival. Losses in 3p (98.3%) were most prevalent and included 32 (27.6%) monosomies of chromosome 3 and 84 (72.4%) structural aberrations involving 3p, of which 36 were unbalanced translocations, der(3)t(3;5)(p11-p22;q13-q31), resulting in duplication of 5q sequences. Patients with gain of 5q31-qter resulting from either polysomies or structural rearrangements of 5q, the most frequent of which was der(3)t(3;5), had a significantly better outcome than those without this aberration (P = 0.001). There was no association between gain of 5q or der(3)t(3;5) and any of the well-known variables for prognosis, including low versus high clinical stage and grade of malignancy. Among additional chromosomal aberrations, loss of chromosome 9/9p was associated with distant metastasis at diagnosis (P = 0.006). The data indicate that gain of 5q identifies a clinically favorable cytogenetic variant of clear cell RCC and demonstrate the impact of specific chromosome aberrations as additional prognostic indicators in clear cell RCC.
- Addresses
- Institute of Pathology, Georg August University Hospital Göttingen, 37075 Göttingen, Germany. bastian.gunawan@med.uni-goettingen.de
- Autoren
- B Gunawan
- W Huber
- M Holtrup
- A von Heydebreck
- T Efferth
- A Poustka
- RH Ringert
- G Jakse
- L Füzesi
- eISSN
- 1538-7445
- Externe Identifier
- PubMed Identifier: 11691785
- Open access
- false
- ISSN
- 0008-5472
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- Cancer research
- Schlüsselwörter
- Chromosomes, Human, Pair 5
- Humans
- Adenocarcinoma, Clear Cell
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Chromosome Aberrations
- Neoplasm Staging
- Prognosis
- Survival Rate
- Follow-Up Studies
- Karyotyping
- Adult
- Aged
- Aged, 80 and over
- Middle Aged
- Female
- Male
- Sprache
- eng
- Medium
- Paginierung
- 7731 - 7738
- Datum der Veröffentlichung
- 2001
- Status
- Published
- Datum der Datenerfassung
- 2001
- Titel
- Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 61
Data source: Europe PubMed Central
- Abstract
- To evaluate the prognostic significance of cytogenetic findings in clear cell renal cell carcinoma (RCC), cytogenetic results of 118 primary RCCs were evaluated in relation to classical indicators of prognosis and overall survival. Losses in 3p (98.3%) were most prevalent and included 32 (27.6%) monosomies of chromosome 3 and 84 (72.4%) structural aberrations involving 3p, of which 36 were unbalanced translocations, der(3)t(3;5)(p11-p22;q13-q31), resulting in duplication of 5q sequences. Patients with gain of 5q31-qter resulting from either polysomies or structural rearrangements of 5q, the most frequent of which was der(3)t(3;5), had a significantly better outcome than those without this aberration (P = 0.001). There was no association between gain of 5q or der(3)t(3;5) and any of the well-known variables for prognosis, including low versus high clinical stage and grade of malignancy. Among additional chromosomal aberrations, loss of chromosome 9/9p was associated with distant metastasis at diagnosis (P = 0.006). The data indicate that gain of 5q identifies a clinically favorable cytogenetic variant of clear cell RCC and demonstrate the impact of specific chromosome aberrations as additional prognostic indicators in clear cell RCC.
- Autoren
- B Gunawan
- W Huber
- M Holtrup
- A von Heydebreck
- T Efferth
- A Poustka
- RH Ringert
- G Jakse
- L Füzesi
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/11691785
- ISSN
- 0008-5472
- Ausgabe der Veröffentlichung
- 21
- Zeitschrift
- Cancer Res
- Schlüsselwörter
- Adenocarcinoma, Clear Cell
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Renal Cell
- Chromosome Aberrations
- Chromosomes, Human, Pair 5
- Female
- Follow-Up Studies
- Humans
- Karyotyping
- Kidney Neoplasms
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Survival Rate
- Sprache
- eng
- Country
- United States
- Paginierung
- 7731 - 7738
- Datum der Veröffentlichung
- 2001
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2001
- Titel
- Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 61
Data source: PubMed
- Beziehungen:
- Property of