The Human ATP-Binding Cassette Transporter Genes From the Bench to the Bedside

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Efferth
DOI
10.2174/1566524013364194
ISSN
1566-5240
Ausgabe der Veröffentlichung
1
Zeitschrift
Current Molecular Medicine
Sprache
en
Paginierung
45 - 65
Datum der Veröffentlichung
2001
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/1566524013364194
Datum der Datenerfassung
2015
Titel
The Human ATP-Binding Cassette Transporter Genes From the Bench to the Bedside
Ausgabe der Zeitschrift
1

Data source: Crossref

Other metadata sources:
Abstract
ATP-binding cassette (ABC) transporter genes are ubiquitously present in most organisms from bacteria to man. This gene family is the largest one known as of yet. Still growing, the number of human ABC transporters counts currently 47 members which belong to seven subfamilies. ABC transporters share a similar molecular architecture: (1) Full-structured transporters harbor two symmetric halves each consisting of one nucleotide binding domain (NBD) and one transmembrane domain (TMD). (2) Half-transporters with one NBD and one TMD homo- or heterodimerize to functional transporter complexes. ABC transporters are "traffic ATPases" which hydrolyze ATP and which transport a wide array of molecules or conduct the transport of molecules by stimulating other translocation mechanisms. Many ABC transporters are involved in human inherited or sporadic diseases such as cystic fibrosis, adrenoleukodystrophy, Stargardt's disease, drug-resistant tumors, Dubin-Johnson syndrome, Byler's disease, progressive familiar intrahepatic cholestasis, X-linked sideroblastic anemia and ataxia, persistent hyperinsulimenic hypoglycemia of infancy, and others. The present review summarizes the current findings in basic research and the efforts for bridging the gap to clinical applications in therapy and diagnostics.
Addresses
  • Virtual Campus Rhineland-Palatinate, Mainz, Germany. efferth@vcrp.de
Autoren
DOI
10.2174/1566524013364194
eISSN
1875-5666
Externe Identifier
  • PubMed Identifier: 11899242
Open access
false
ISSN
1566-5240
Ausgabe der Veröffentlichung
1
Zeitschrift
Current molecular medicine
Schlüsselwörter
  • Animals
  • Humans
  • Cystic Fibrosis
  • Adrenoleukodystrophy
  • ATP-Binding Cassette Transporters
  • Biological Transport
  • Genetic Therapy
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
45 - 65
Datum der Veröffentlichung
2001
Status
Published
Datum der Datenerfassung
2002
Titel
The human ATP-binding cassette transporter genes: from the bench to the bedside.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
1

Data source: Europe PubMed Central

Abstract
ATP-binding cassette (ABC) transporter genes are ubiquitously present in most organisms from bacteria to man. This gene family is the largest one known as of yet. Still growing, the number of human ABC transporters counts currently 47 members which belong to seven subfamilies. ABC transporters share a similar molecular architecture: (1) Full-structured transporters harbor two symmetric halves each consisting of one nucleotide binding domain (NBD) and one transmembrane domain (TMD). (2) Half-transporters with one NBD and one TMD homo- or heterodimerize to functional transporter complexes. ABC transporters are "traffic ATPases" which hydrolyze ATP and which transport a wide array of molecules or conduct the transport of molecules by stimulating other translocation mechanisms. Many ABC transporters are involved in human inherited or sporadic diseases such as cystic fibrosis, adrenoleukodystrophy, Stargardt's disease, drug-resistant tumors, Dubin-Johnson syndrome, Byler's disease, progressive familiar intrahepatic cholestasis, X-linked sideroblastic anemia and ataxia, persistent hyperinsulimenic hypoglycemia of infancy, and others. The present review summarizes the current findings in basic research and the efforts for bridging the gap to clinical applications in therapy and diagnostics.
Autoren
  • T Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/11899242
DOI
10.2174/1566524013364194
ISSN
1566-5240
Ausgabe der Veröffentlichung
1
Zeitschrift
Curr Mol Med
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette Transporters
  • Adrenoleukodystrophy
  • Animals
  • Biological Transport
  • Cystic Fibrosis
  • Genetic Therapy
  • Humans
Sprache
eng
Country
Netherlands
Paginierung
45 - 65
Datum der Veröffentlichung
2001
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2002
Titel
The human ATP-binding cassette transporter genes: from the bench to the bedside.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
1

Data source: PubMed

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