Protein expression profiles of non-small cell lung carcinomas:: Correlation with histological subtype

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000177259900055&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: 580WP
  • PubMed Identifier: 12174921
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • lung cancer
  • oncogenes
  • proliferation
  • apoptosis
  • angiogenesis
  • resistance
Paginierung
2321 - 2324
Datum der Veröffentlichung
2002
Status
Published
Titel
Protein expression profiles of non-small cell lung carcinomas:: Correlation with histological subtype
Sub types
  • Article
Ausgabe der Zeitschrift
22

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
Of the four major subtypes of lung cancer, three subtypes, namely squamous cell lung carcinomas, adenocarcinomas and large cell carcinomas are usually combined within the larger group of non-small cell lung carcinomas (NSCLC). However, the heterogeneity that exists within any given tumor has also been clearly demonstrated. In order to study whether or not the protein expression profile is different in the histological subtypes of NSCLC, the expression of several parameters including proto-oncogene and suppressor gene products, proliferative, apoptotic, angiogenic and resistance factors was evaluated immunohistochemically in 139 NSCLC (45 adenocarcinomas and 94 squamous cell lung carcinomas). In both histological subtypes the percentage of positively-stained parameters was determined. The expression of the proteins ERBB2, JUN, RAS and tissue factor was significantly higher in adenocarcinomas compared to squamous cell lung carcinomas. In contrast, all resistance proteins analyzed were more frequently expressed in squamous cell lung carcinomas in comparison to adenocarcinomas, though only GST-pi reached statistical significance. Apoptotic factors and angiogenic factors were higher in adenocarcinomas, but these differences did not reach statistical significance. In conclusion, the protein expression profiles of adenocarcinomas and squamous cell carcinomas differ from each other. Squamous cell lung carcinomas in comparison to adenocarcinomas are characterized by a down-regulation of some oncogenes and an up-regulation of several resistance factors. These findings could explain the different biological behaviour and treatment response of these tumours.
Addresses
  • German Cancer Research Center, Heidelberg.
Autoren
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 12174921
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
Anticancer research
Schlüsselwörter
  • Humans
  • Adenocarcinoma
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Squamous Cell
  • Lung Neoplasms
  • Neovascularization, Pathologic
  • Neoplasm Proteins
  • Gene Expression Profiling
  • Genes, jun
  • Genes, ras
  • Proto-Oncogene Mas
Sprache
eng
Medium
Print
Paginierung
2321 - 2324
Datum der Veröffentlichung
2002
Status
Published
Datum der Datenerfassung
2002
Titel
Protein expression profiles of non-small cell lung carcinomas: correlation with histological subtype.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: Europe PubMed Central

Abstract
Of the four major subtypes of lung cancer, three subtypes, namely squamous cell lung carcinomas, adenocarcinomas and large cell carcinomas are usually combined within the larger group of non-small cell lung carcinomas (NSCLC). However, the heterogeneity that exists within any given tumor has also been clearly demonstrated. In order to study whether or not the protein expression profile is different in the histological subtypes of NSCLC, the expression of several parameters including proto-oncogene and suppressor gene products, proliferative, apoptotic, angiogenic and resistance factors was evaluated immunohistochemically in 139 NSCLC (45 adenocarcinomas and 94 squamous cell lung carcinomas). In both histological subtypes the percentage of positively-stained parameters was determined. The expression of the proteins ERBB2, JUN, RAS and tissue factor was significantly higher in adenocarcinomas compared to squamous cell lung carcinomas. In contrast, all resistance proteins analyzed were more frequently expressed in squamous cell lung carcinomas in comparison to adenocarcinomas, though only GST-pi reached statistical significance. Apoptotic factors and angiogenic factors were higher in adenocarcinomas, but these differences did not reach statistical significance. In conclusion, the protein expression profiles of adenocarcinomas and squamous cell carcinomas differ from each other. Squamous cell lung carcinomas in comparison to adenocarcinomas are characterized by a down-regulation of some oncogenes and an up-regulation of several resistance factors. These findings could explain the different biological behaviour and treatment response of these tumours.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/12174921
ISSN
0250-7005
Ausgabe der Veröffentlichung
4
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Adenocarcinoma
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Squamous Cell
  • Gene Expression Profiling
  • Genes, jun
  • Genes, ras
  • Humans
  • Lung Neoplasms
  • Neoplasm Proteins
  • Neovascularization, Pathologic
  • Proto-Oncogene Mas
Sprache
eng
Country
Greece
Paginierung
2321 - 2324
Datum der Veröffentlichung
2002
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2002
Titel
Protein expression profiles of non-small cell lung carcinomas: correlation with histological subtype.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: PubMed

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