Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- M Volm
- A Sauerbrey
- F Zintl
- R Koomägi
- T Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000177408400008&DestLinkType=FullRecord&DestApp=WOS_CPL
- Externe Identifier
- Clarivate Analytics Document Solution ID: 583LB
- PubMed Identifier: 12168056
- ISSN
- 1021-335X
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- ONCOLOGY REPORTS
- Schlüsselwörter
- childhood ALL
- protein expression profile
- relapses
- resistance proteins
- proto-oncogenes
- cluster-analysis
- Paginierung
- 965 - 969
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Titel
- Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses
- Sub types
- Article
- Ausgabe der Zeitschrift
- 9
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- M Volm
- A Sauerbrey
- F Zintl
- R Koomagi
- T Efferth
- DOI
- 10.3892/or.9.5.965
- eISSN
- 1791-2431
- ISSN
- 1021-335X
- Zeitschrift
- Oncology Reports
- Online publication date
- 2002
- Status
- Published online
- Herausgeber
- Spandidos Publications
- Herausgeber URL
- http://dx.doi.org/10.3892/or.9.5.965
- Datum der Datenerfassung
- 2017
- Titel
- Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses
Data source: Crossref
- Abstract
- The purpose of this investigation was to evaluate the expression profile of proteins involved in children with newly diagnosed acute lymphoblastic leukemia (ALL) children who are developing relapses. For this reason, the expressions of 10 proteins including proto-oncogene and tumor suppressor gene products, proliferative factors and resistance parameters in 104 initial cases of childhood ALL were analyzed and the proteins correlated with ALL patients who experienced relapses. Applying immunocytochemical assays, we found that 4 out of the 10 parameters revealed a relationship to developing relapses (Fisher's exact tests). These were the oncogene product Fos (p=0.002), the drug resistance proteins glutathione S-transferase (p=0.008) and P-glycoprotein (P-pg/MDR1) (p=0.07) and protein kinase C (p=0.01). By means of hierarchical cluster analysis, we were able to show that the patients could be separated according to their protein expression profile into clusters consisting of patients whose ALL relapsed later and of patients who did not show relapses in the future.
- Addresses
- German Cancer Research Center, Heidelberg, Germany.
- Autoren
- M Volm
- A Sauerbrey
- F Zintl
- R Koomägi
- T Efferth
- DOI
- 10.3892/or.9.5.965
- eISSN
- 1791-2431
- Externe Identifier
- PubMed Identifier: 12168056
- Open access
- false
- ISSN
- 1021-335X
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Oncology reports
- Schlüsselwörter
- Humans
- Recurrence
- Glutathione Transferase
- Protein Kinase C
- Treatment Outcome
- Oligonucleotide Array Sequence Analysis
- Immunohistochemistry
- Child
- Female
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Mas
- Sprache
- eng
- Medium
- Paginierung
- 965 - 969
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Datum der Datenerfassung
- 2002
- Titel
- Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 9
Data source: Europe PubMed Central
- Abstract
- The purpose of this investigation was to evaluate the expression profile of proteins involved in children with newly diagnosed acute lymphoblastic leukemia (ALL) children who are developing relapses. For this reason, the expressions of 10 proteins including proto-oncogene and tumor suppressor gene products, proliferative factors and resistance parameters in 104 initial cases of childhood ALL were analyzed and the proteins correlated with ALL patients who experienced relapses. Applying immunocytochemical assays, we found that 4 out of the 10 parameters revealed a relationship to developing relapses (Fisher's exact tests). These were the oncogene product Fos (p=0.002), the drug resistance proteins glutathione S-transferase (p=0.008) and P-glycoprotein (P-pg/MDR1) (p=0.07) and protein kinase C (p=0.01). By means of hierarchical cluster analysis, we were able to show that the patients could be separated according to their protein expression profile into clusters consisting of patients whose ALL relapsed later and of patients who did not show relapses in the future.
- Autoren
- M Volm
- A Sauerbrey
- F Zintl
- R Koomägi
- T Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/12168056
- DOI
- 10.3892/or.9.5.965
- ISSN
- 1021-335X
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Oncol Rep
- Schlüsselwörter
- Child
- Female
- Glutathione Transferase
- Humans
- Immunohistochemistry
- Male
- Oligonucleotide Array Sequence Analysis
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Protein Kinase C
- Proto-Oncogene Mas
- Recurrence
- Treatment Outcome
- Sprache
- eng
- Country
- Greece
- Paginierung
- 965 - 969
- Datum der Veröffentlichung
- 2002
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2003
- Titel
- Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 9
Data source: PubMed
- Beziehungen:
- Property of