Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases

Publication type:
Journal article
Metadata:
Autoren
  • M Volm
  • R Koomägi
  • J Mattern
  • T Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000176864900003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1023/A:1016361924216
Externe Identifier
  • Clarivate Analytics Document Solution ID: 573ZY
  • PubMed Identifier: 12198766
ISSN
0262-0898
Ausgabe der Veröffentlichung
5
Zeitschrift
CLINICAL & EXPERIMENTAL METASTASIS
Schlüsselwörter
  • immunohistochemistry
  • lymph node involvement
  • metastatic patterns
  • protein expressions
  • squamous cell lung cancer
Paginierung
385 - 390
Datum der Veröffentlichung
2002
Status
Published
Titel
Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases
Sub types
  • Article
Ausgabe der Zeitschrift
19

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Manfred Volm
  • Reet Koomägi
  • Jürgen Mattern
  • Thomas Efferth
DOI
10.1023/a:1016361924216
ISSN
0262-0898
Ausgabe der Veröffentlichung
5
Zeitschrift
Clinical and Experimental Metastasis
Paginierung
385 - 390
Datum der Veröffentlichung
2002
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1023/a:1016361924216
Datum der Datenerfassung
2012
Ausgabe der Zeitschrift
19

Data source: Crossref

Abstract
The purpose of this investigation was to evaluate firstly whether different protein expression patterns exist in primary squamous cell lung carcinomas of patients with and without lymph node involvement and secondly, whether or not different patterns exist in tumours with positive lymph nodes. For this reason, formalin-fixed, paraffin-embedded specimens from 130 patients with squamous cell lung carcinomas were analyzed by immunohistochemistry. In a first step, proteins were selected which showed a relationship to lymph node involvement. The expression of JUN, ERBB2, MYC, cyclin D, PCNA, bFGF, VEGF and Hsp70 proteins revealed a positive correlation to lymph node involvement. In contrast, caspase-3, Fas ligand, Fas/CD95, and PAI showed an inverse correlation to lymph node involvement. In a second step, these parameters were further analyzed by hierarchical cluster analyses. The resulting clusters were correlated to patients with or without lymph node involvement. The data show that different protein expression patterns exist between primary squamous cell lung carcinomas with and without lymph node involvement and within carcinomas with lymph node involvement. The data suggest that various metastasis profiles exist.
Addresses
  • German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Autoren
  • Manfred Volm
  • Reet Koomägi
  • Jürgen Mattern
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1023/a:1016361924216
eISSN
1573-7276
Externe Identifier
  • PubMed Identifier: 12198766
Open access
false
ISSN
0262-0898
Ausgabe der Veröffentlichung
5
Zeitschrift
Clinical & experimental metastasis
Schlüsselwörter
  • Humans
  • Carcinoma, Squamous Cell
  • Lung Neoplasms
  • Lymphatic Metastasis
  • Growth Substances
  • Cell Cycle Proteins
  • Neoplasm Proteins
  • Oncogene Proteins
  • Life Tables
  • Incidence
  • Multivariate Analysis
  • Cluster Analysis
  • Gene Expression Profiling
  • Middle Aged
  • Female
  • Male
Sprache
eng
Medium
Print
Paginierung
385 - 390
Datum der Veröffentlichung
2002
Status
Published
Datum der Datenerfassung
2002
Titel
Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
19

Data source: Europe PubMed Central

Abstract
The purpose of this investigation was to evaluate firstly whether different protein expression patterns exist in primary squamous cell lung carcinomas of patients with and without lymph node involvement and secondly, whether or not different patterns exist in tumours with positive lymph nodes. For this reason, formalin-fixed, paraffin-embedded specimens from 130 patients with squamous cell lung carcinomas were analyzed by immunohistochemistry. In a first step, proteins were selected which showed a relationship to lymph node involvement. The expression of JUN, ERBB2, MYC, cyclin D, PCNA, bFGF, VEGF and Hsp70 proteins revealed a positive correlation to lymph node involvement. In contrast, caspase-3, Fas ligand, Fas/CD95, and PAI showed an inverse correlation to lymph node involvement. In a second step, these parameters were further analyzed by hierarchical cluster analyses. The resulting clusters were correlated to patients with or without lymph node involvement. The data show that different protein expression patterns exist between primary squamous cell lung carcinomas with and without lymph node involvement and within carcinomas with lymph node involvement. The data suggest that various metastasis profiles exist.
Autoren
  • Manfred Volm
  • Reet Koomägi
  • Jürgen Mattern
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/12198766
DOI
10.1023/a:1016361924216
ISSN
0262-0898
Ausgabe der Veröffentlichung
5
Zeitschrift
Clin Exp Metastasis
Schlüsselwörter
  • Carcinoma, Squamous Cell
  • Cell Cycle Proteins
  • Cluster Analysis
  • Female
  • Gene Expression Profiling
  • Growth Substances
  • Humans
  • Incidence
  • Life Tables
  • Lung Neoplasms
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Proteins
  • Oncogene Proteins
Sprache
eng
Country
Netherlands
Paginierung
385 - 390
Datum der Veröffentlichung
2002
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2002
Titel
Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
19

Data source: PubMed

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