Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug resistant tumor cells

Publication type:
Journal article
Metadata:
Autoren
  • T Efferth
  • A Olbrich
  • A Sauerbrey
  • DD Ross
  • E Gebhart
  • M Neugebauer
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000180514600063&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: 637MA
  • PubMed Identifier: 12553060
ISSN
0250-7005
Ausgabe der Veröffentlichung
6C
Zeitschrift
ANTICANCER RESEARCH
Schlüsselwörter
  • chemotherapy
  • endoperoxide
  • multidrug resistance gene 1
  • multidrug resistance-related protein 1
  • breast cancer resistance protein
Paginierung
4221 - 4224
Datum der Veröffentlichung
2002
Status
Published
Titel
Activity of ascaridol from the anthelmintic herb <i>Chenopodium anthelminticum</i> L. against sensitive and multidrug resistant tumor cells
Sub types
  • Article
Ausgabe der Zeitschrift
22

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
Ascaridol is the active principle of the American wormseed Chenopodium anthelminticum L. We isolated ascaridol from a commercial preparation of Chenopodium oil and analyzed its activity against different tumor cell lines in vitro (CCRF-CEM, HL60, MDA-MB-231). Multidrug-resistant (MDR) counterparts of these cell lines express differentially the MDR-conferring ATP-binding cassette transporter genes MDR1, MRP1 and BCRP, respectively. We found that ascaridol exerts antineoplastic activity. The findings of the present investigation are the first hint that ascaridol may be an interesting novel candidate drug for cancer treatment.
Addresses
  • Virtual Campus Rhineland-Palatinate, Saac Fulda-Allee 3, 55124 Mainz, Germany. efferth@vcrp.de
Autoren
  • Thomas Efferth
  • Armin Olbrich
  • Axel Sauerbrey
  • Douglas D Ross
  • Erich Gebhart
  • Michael Neugebauer
eISSN
1791-7530
Externe Identifier
  • PubMed Identifier: 12553060
Open access
false
ISSN
0250-7005
Ausgabe der Veröffentlichung
6C
Zeitschrift
Anticancer research
Schlüsselwörter
  • HL-60 Cells
  • Tumor Cells, Cultured
  • Humans
  • Chenopodium
  • Breast Neoplasms
  • Peroxides
  • Monoterpenes
  • Antineoplastic Agents, Phytogenic
  • Drug Screening Assays, Antitumor
  • Drug Resistance, Multiple
  • Molecular Conformation
  • Drug Resistance, Neoplasm
  • Cyclohexane Monoterpenes
Sprache
eng
Medium
Print
Paginierung
4221 - 4224
Datum der Veröffentlichung
2002
Status
Published
Datum der Datenerfassung
2003
Titel
Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: Europe PubMed Central

Abstract
Ascaridol is the active principle of the American wormseed Chenopodium anthelminticum L. We isolated ascaridol from a commercial preparation of Chenopodium oil and analyzed its activity against different tumor cell lines in vitro (CCRF-CEM, HL60, MDA-MB-231). Multidrug-resistant (MDR) counterparts of these cell lines express differentially the MDR-conferring ATP-binding cassette transporter genes MDR1, MRP1 and BCRP, respectively. We found that ascaridol exerts antineoplastic activity. The findings of the present investigation are the first hint that ascaridol may be an interesting novel candidate drug for cancer treatment.
Autoren
  • Thomas Efferth
  • Armin Olbrich
  • Axel Sauerbrey
  • Douglas D Ross
  • Erich Gebhart
  • Michael Neugebauer
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/12553060
ISSN
0250-7005
Ausgabe der Veröffentlichung
6C
Zeitschrift
Anticancer Res
Schlüsselwörter
  • Antineoplastic Agents, Phytogenic
  • Breast Neoplasms
  • Chenopodium
  • Cyclohexane Monoterpenes
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Conformation
  • Monoterpenes
  • Peroxides
  • Tumor Cells, Cultured
Sprache
eng
Country
Greece
Paginierung
4221 - 4224
Datum der Veröffentlichung
2002
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2003
Titel
Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: PubMed

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