Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases

Autoren

Thomas Efferth

DOI

10.1016/s1568-1637(02)00046-6

ISSN

1568-1637

Ausgabe der Veröffentlichung

1

Zeitschrift

Ageing Research Reviews

Sprache

en

Paginierung

11 - 24

Datum der Veröffentlichung

2003

Status

Published

Herausgeber

Elsevier BV

Herausgeber URL

http://dx.doi.org/10.1016/s1568-1637(02)00046-6

Datum der Datenerfassung

2023

Titel

Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases

Ausgabe der Zeitschrift

2

Data source: Crossref

Abstract

The family of adenosine triphosphate (ATP)-binding cassette (ABC) transporters is the largest gene family known. While some ABC transporters translocate single substances across membranes with high specificity, others transport a wide variety of different lipophilic compounds. They are responsible for many physiological processes and are also implicated in a number of diseases. The present review focuses on ABC transporter genes which are involved in ageing and age-related diseases. Expression of ABCB1 (MDR1, P-glycoprotein) increases with age in CD4(+) and CD8(+) T-lymphocytes indicating that P-glycoprotein may be involved in the secretion of cytokines, growth factors, and cytotoxic molecules. As T cells in aged individuals are hyporesponsive leading to a reduced immunodefence capability, a role of ABCB1 in age-related immunological processes is presumed. The ABCA1 (ABC1) gene product translocates intracellular cholesterol and phospholipids out of macrophages. Genetic aberrations in ABCA1 cause perturbations in lipoprotein metabolism and contribute to atherosclerosis. ABCA4 (ABCR) represents a retina-specific ABC transporter expressed in rod photoreceptor cells. The ABCA4 gene product translocates retinyl-derivatives. Mutations in the ABCA4 gene contribute to age-related macular degeneration. Polymorphisms in the sulfonylurea receptor gene (ABCC8, SUR1) are associated with non-insulin-dependent diabetes mellitus (NIDDM). Sulfonylureas inhibit potassium conductance and are used to treat NIDDM by stimulation of insulin secretion across ATP-sensitive potassium channels in pancreatic beta-cell membranes. Possible diagnostic and therapeutic implications of ABC transporters for age-related diseases are discussed.

Addresses

Virtual Campus Rhineland-Palatinate, Rodeneck Platz 2, 55126, Mainz, Germany. efferth@vcrp.de

Autoren

Thomas Efferth
Thomas Efferth

DOI

10.1016/s1568-1637(02)00046-6

eISSN

1872-9649

Externe Identifier

PubMed Identifier: 12437993

Open access

false

ISSN

1568-1637

Ausgabe der Veröffentlichung

1

Zeitschrift

Ageing research reviews

Schlüsselwörter

Animals
Humans
Macular Degeneration
Arteriosclerosis
Diabetes Mellitus, Type 2
ATP-Binding Cassette Transporters
Gene Expression Regulation
Aging

Sprache

eng

Medium

Print

Paginierung

11 - 24

Datum der Veröffentlichung

2003

Status

Published

Datum der Datenerfassung

2002

Titel

Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases.

Sub types

Review
Journal Article

Ausgabe der Zeitschrift

2

Data source: Europe PubMed Central

Abstract

The family of adenosine triphosphate (ATP)-binding cassette (ABC) transporters is the largest gene family known. While some ABC transporters translocate single substances across membranes with high specificity, others transport a wide variety of different lipophilic compounds. They are responsible for many physiological processes and are also implicated in a number of diseases. The present review focuses on ABC transporter genes which are involved in ageing and age-related diseases. Expression of ABCB1 (MDR1, P-glycoprotein) increases with age in CD4(+) and CD8(+) T-lymphocytes indicating that P-glycoprotein may be involved in the secretion of cytokines, growth factors, and cytotoxic molecules. As T cells in aged individuals are hyporesponsive leading to a reduced immunodefence capability, a role of ABCB1 in age-related immunological processes is presumed. The ABCA1 (ABC1) gene product translocates intracellular cholesterol and phospholipids out of macrophages. Genetic aberrations in ABCA1 cause perturbations in lipoprotein metabolism and contribute to atherosclerosis. ABCA4 (ABCR) represents a retina-specific ABC transporter expressed in rod photoreceptor cells. The ABCA4 gene product translocates retinyl-derivatives. Mutations in the ABCA4 gene contribute to age-related macular degeneration. Polymorphisms in the sulfonylurea receptor gene (ABCC8, SUR1) are associated with non-insulin-dependent diabetes mellitus (NIDDM). Sulfonylureas inhibit potassium conductance and are used to treat NIDDM by stimulation of insulin secretion across ATP-sensitive potassium channels in pancreatic beta-cell membranes. Possible diagnostic and therapeutic implications of ABC transporters for age-related diseases are discussed.

Autoren

Thomas Efferth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/12437993

DOI

10.1016/s1568-1637(02)00046-6

ISSN

1568-1637

Ausgabe der Veröffentlichung

1

Zeitschrift

Ageing Res Rev

Schlüsselwörter

ATP-Binding Cassette Transporters
Aging
Animals
Arteriosclerosis
Diabetes Mellitus, Type 2
Gene Expression Regulation
Humans
Macular Degeneration

Sprache

eng

Country

England

Paginierung

11 - 24

PII

S1568163702000466

Datum der Veröffentlichung

2003

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2003

Titel

Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

2

Data source: PubMed

Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases

Tools