Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities

Publication type:
Journal article
Metadata:
Autoren
  • JS Wang
  • YT Zheng
  • T Efferth
  • RR Wang
  • YM Shen
  • XJ Hao
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000228403300015&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phytochem.2005.02.003
Externe Identifier
  • Clarivate Analytics Document Solution ID: 916RK
  • PubMed Identifier: 15771893
ISSN
0031-9422
Ausgabe der Veröffentlichung
6
Zeitschrift
PHYTOCHEMISTRY
Schlüsselwörter
  • Glycosmis montana
  • rutaceae
  • diprenylated indole
  • carbozole
  • anti-HIV
  • C8166
  • cytotoxicity
  • leukaemia
Paginierung
697 - 701
Datum der Veröffentlichung
2005
Status
Published
Titel
Indole and carbazole alkaloids from <i>Glycosmis montana</i> with weak anti-HIV and cytotoxic activities
Sub types
  • Article
Ausgabe der Zeitschrift
66

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Junsong Wang
  • Yongtang Zheng
  • Thomas Efferth
  • Ruirui Wang
  • Yuemao Shen
  • Xiaojiang Hao
DOI
10.1016/j.phytochem.2005.02.003
ISSN
0031-9422
Ausgabe der Veröffentlichung
6
Zeitschrift
Phytochemistry
Sprache
en
Paginierung
697 - 701
Datum der Veröffentlichung
2005
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phytochem.2005.02.003
Datum der Datenerfassung
2019
Titel
Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities
Ausgabe der Zeitschrift
66

Data source: Crossref

Abstract
A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.
Addresses
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongton, Kunming, Yunnan 650204, PR China.
Autoren
  • Junsong Wang
  • Yongtang Zheng
  • Thomas Efferth
  • Thomas Efferth
  • Ruirui Wang
  • Yuemao Shen
  • Xiaojiang Hao
DOI
10.1016/j.phytochem.2005.02.003
eISSN
1873-3700
Externe Identifier
  • PubMed Identifier: 15771893
Open access
false
ISSN
0031-9422
Ausgabe der Veröffentlichung
6
Zeitschrift
Phytochemistry
Schlüsselwörter
  • Cell Line
  • Cell Line, Tumor
  • Humans
  • HIV-1
  • Rutaceae
  • Plant Components, Aerial
  • Leukemia
  • Indoles
  • Carbazoles
  • Antineoplastic Agents, Phytogenic
  • Anti-HIV Agents
  • Inhibitory Concentration 50
  • Molecular Structure
Sprache
eng
Medium
Print
Paginierung
697 - 701
Datum der Veröffentlichung
2005
Status
Published
Datum der Datenerfassung
2005
Titel
Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
66

Data source: Europe PubMed Central

Abstract
A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.
Autoren
  • Junsong Wang
  • Yongtang Zheng
  • Thomas Efferth
  • Ruirui Wang
  • Yuemao Shen
  • Xiaojiang Hao
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/15771893
DOI
10.1016/j.phytochem.2005.02.003
ISSN
0031-9422
Ausgabe der Veröffentlichung
6
Zeitschrift
Phytochemistry
Schlüsselwörter
  • Anti-HIV Agents
  • Antineoplastic Agents, Phytogenic
  • Carbazoles
  • Cell Line
  • Cell Line, Tumor
  • HIV-1
  • Humans
  • Indoles
  • Inhibitory Concentration 50
  • Leukemia
  • Molecular Structure
  • Plant Components, Aerial
  • Rutaceae
Sprache
eng
Country
England
Paginierung
697 - 701
PII
S0031-9422(05)00054-3
Datum der Veröffentlichung
2005
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2005
Titel
Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
66

Data source: PubMed

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