Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid

Publication type:
Journal article
Metadata:
Autoren
  • S Majumder
  • P Dutta
  • P Mukherjee
  • ER Datta
  • T Efferth
  • S Bhattacharya
  • SK Choudhuri
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000242952100003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.canlet.2005.11.030
eISSN
1872-7980
Externe Identifier
  • Clarivate Analytics Document Solution ID: 118OR
  • PubMed Identifier: 16410038
ISSN
0304-3835
Ausgabe der Veröffentlichung
1
Zeitschrift
CANCER LETTERS
Schlüsselwörter
  • oxalyl bis (N-phenyl) hydroxamic acid (OBPHA)
  • copper N-(2-hydroxy acetophenone) glycinate (CuNG)
  • doxorubicin (Dox)
  • multiple drug resistance (MDR)
  • chemosensitivity
Paginierung
16 - 23
Datum der Veröffentlichung
2006
Status
Published
Titel
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper <i>N</i>-(2-hydroxy acetophenone) glycinate and oxalyl bis (<i>N</i>-phenyl) hydroxamic acid
Sub types
  • Article
Ausgabe der Zeitschrift
244

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • S Majumder
  • P Dutta
  • P Mukherjee
  • ER Datta
  • T Efferth
  • S Bhattacharya
  • SK Choudhuri
DOI
10.1016/j.canlet.2005.11.030
ISSN
0304-3835
Ausgabe der Veröffentlichung
1
Zeitschrift
Cancer Letters
Sprache
en
Paginierung
16 - 23
Datum der Veröffentlichung
2006
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.canlet.2005.11.030
Datum der Datenerfassung
2021
Titel
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid
Ausgabe der Zeitschrift
244

Data source: Crossref

Abstract
Multiple drug resistance (MDR) represents a major obstacle to successful application of chemotherapy and a basic problem in cancer biology. MDR occurs at the cellular level and is multi-factorial in nature. The multidrug resistance gene, MDR1, and its gene product P-glycoprotein (P-gp) are now well known as an important determinant of MDR. Much effort has been devoted to develop P-gp inhibitors to modulate resistance. However, most of these resistance-modifying agents (RMA) are too toxic at the required doses. Therefore, the development of novel RMAs to overcome MDR represents a major challenge to modern cancer chemotherapy. In the present investigation, we describe the effect of oxalyl bis (N-phenyl) hydroxamic acid (OBPHA) and copper N-(2-hydroxy acetophenone) glycinate (CuNG) on multidrug-resistant P-gp-expressing CEM/ADR5000 T-cell acute lymphoblastic leukemia cells. CuNG, a known depleting agent for glutathione (GSH) and inhibitor of glutathione S-transferase (GST) and multidrug resistance-related protein 1 (MRP1), also inhibited P-gp-mediated doxorubicin accumulation and retention. The resistance-modifying effects of OBPHA were stronger than that of CuNG. Both novel RMAs overcame drug resistance more efficiently than verapamil, a well-known P-gp inhibitor. OBPHA and CuNG exposure resulted in an increased doxorubicin accumulation after 1-3h incubation by down-regulation of P-gp expression after 24h incubation. This is a clue that different mechanisms may contribute to modulation of P-gp-mediated drug resistance by these compounds.
Addresses
  • Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700026, India.
Autoren
  • S Majumder
  • P Dutta
  • P Mukherjee
  • ER Datta
  • T Efferth
  • T Efferth
  • S Bhattacharya
  • SK Choudhuri
DOI
10.1016/j.canlet.2005.11.030
eISSN
1872-7980
Externe Identifier
  • PubMed Identifier: 16410038
Open access
false
ISSN
0304-3835
Ausgabe der Veröffentlichung
1
Zeitschrift
Cancer letters
Schlüsselwörter
  • Tumor Cells, Cultured
  • Humans
  • Benzeneacetamides
  • Verapamil
  • Hydroxamic Acids
  • Oxalates
  • Organometallic Compounds
  • Doxorubicin
  • Glycine
  • Calcium Channel Blockers
  • Antibiotics, Antineoplastic
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Leukemia-Lymphoma, Adult T-Cell
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print-Electronic
Online publication date
2006
Paginierung
16 - 23
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2006
Titel
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
244

Data source: Europe PubMed Central

Abstract
Multiple drug resistance (MDR) represents a major obstacle to successful application of chemotherapy and a basic problem in cancer biology. MDR occurs at the cellular level and is multi-factorial in nature. The multidrug resistance gene, MDR1, and its gene product P-glycoprotein (P-gp) are now well known as an important determinant of MDR. Much effort has been devoted to develop P-gp inhibitors to modulate resistance. However, most of these resistance-modifying agents (RMA) are too toxic at the required doses. Therefore, the development of novel RMAs to overcome MDR represents a major challenge to modern cancer chemotherapy. In the present investigation, we describe the effect of oxalyl bis (N-phenyl) hydroxamic acid (OBPHA) and copper N-(2-hydroxy acetophenone) glycinate (CuNG) on multidrug-resistant P-gp-expressing CEM/ADR5000 T-cell acute lymphoblastic leukemia cells. CuNG, a known depleting agent for glutathione (GSH) and inhibitor of glutathione S-transferase (GST) and multidrug resistance-related protein 1 (MRP1), also inhibited P-gp-mediated doxorubicin accumulation and retention. The resistance-modifying effects of OBPHA were stronger than that of CuNG. Both novel RMAs overcame drug resistance more efficiently than verapamil, a well-known P-gp inhibitor. OBPHA and CuNG exposure resulted in an increased doxorubicin accumulation after 1-3h incubation by down-regulation of P-gp expression after 24h incubation. This is a clue that different mechanisms may contribute to modulation of P-gp-mediated drug resistance by these compounds.
Date of acceptance
2005
Autoren
  • S Majumder
  • P Dutta
  • P Mukherjee
  • ER Datta
  • T Efferth
  • S Bhattacharya
  • SK Choudhuri
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16410038
DOI
10.1016/j.canlet.2005.11.030
ISSN
0304-3835
Ausgabe der Veröffentlichung
1
Zeitschrift
Cancer Lett
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antibiotics, Antineoplastic
  • Benzeneacetamides
  • Calcium Channel Blockers
  • Doxorubicin
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Glycine
  • Humans
  • Hydroxamic Acids
  • Leukemia-Lymphoma, Adult T-Cell
  • Organometallic Compounds
  • Oxalates
  • Tumor Cells, Cultured
  • Verapamil
Sprache
eng
Country
Ireland
Paginierung
16 - 23
PII
S0304-3835(05)01033-5
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2007
Titel
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
244

Data source: PubMed

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