Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- T Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000236267300004&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.2174/138945006776359412
- eISSN
- 1873-5592
- Externe Identifier
- Clarivate Analytics Document Solution ID: 025LJ
- PubMed Identifier: 16611029
- ISSN
- 1389-4501
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- CURRENT DRUG TARGETS
- Schlüsselwörter
- angiogenesis
- apoptosis
- multidrug resistance
- oncogenes
- oxidative stress
- pharmacogenomics
- sesquiterpene lactones
- traditional Chinese medicine
- tumor suppressor genes
- Paginierung
- 407 - 421
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Titel
- Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
- Sub types
- Review
- Ausgabe der Zeitschrift
- 7
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Thomas Efferth
- DOI
- 10.2174/138945006776359412
- ISSN
- 1389-4501
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Current Drug Targets
- Sprache
- en
- Paginierung
- 407 - 421
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Herausgeber
- Bentham Science Publishers Ltd.
- Herausgeber URL
- http://dx.doi.org/10.2174/138945006776359412
- Datum der Datenerfassung
- 2015
- Titel
- Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells
- Ausgabe der Zeitschrift
- 7
Data source: Crossref
- Abstract
- Secondary metabolites from plants can serve as defense against herbivores, microbes, viruses or competing plants. Many compounds from medicinal plants have pharmacological activities and thus may be a source for novel anti-tumor agents. We have analyzed natural products from traditional Chinese medicine during the past decade and focused our interest on the compound artemisinin from Artemisia annua L. (qinghao, sweet wormwood) and its derivatives. In addition to their anti-malarial properties, artemisinins are cytotoxic for cancer cells. The present review focuses on the mechanisms of action of artemisinins in cancer cells relating to: 1. anti-proliferative and anti-angiogenic effects, 2. induction of apoptosis, 3. oxidative stress, 4. oncogenes and tumor suppressor genes, and 5. multidrug resistance. Data on putative target molecules of artemisinins are presented and discussed, e.g. the translationally controlled tumor protein (TCTP). Emphasis is given to pharmacogenomic approaches to analyze the pleiotropic nature of mechanisms of artemisinins in cancer cells.
- Addresses
- German Cancer Research Center, M070, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. t.efferth@dkfz.de
- Autoren
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.2174/138945006776359412
- eISSN
- 1873-5592
- Externe Identifier
- PubMed Identifier: 16611029
- Open access
- false
- ISSN
- 1389-4501
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Current drug targets
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Humans
- Neoplasms
- Sesquiterpenes
- Artemisinins
- Angiogenesis Inhibitors
- Antineoplastic Agents, Phytogenic
- Genetic Engineering
- Pharmacogenetics
- Apoptosis
- Cell Proliferation
- Oxidative Stress
- Drug Resistance, Neoplasm
- Genes, Tumor Suppressor
- Tumor Protein, Translationally-Controlled 1
- Sprache
- eng
- Medium
- Paginierung
- 407 - 421
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Datum der Datenerfassung
- 2006
- Titel
- Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 7
Data source: Europe PubMed Central
- Abstract
- Secondary metabolites from plants can serve as defense against herbivores, microbes, viruses or competing plants. Many compounds from medicinal plants have pharmacological activities and thus may be a source for novel anti-tumor agents. We have analyzed natural products from traditional Chinese medicine during the past decade and focused our interest on the compound artemisinin from Artemisia annua L. (qinghao, sweet wormwood) and its derivatives. In addition to their anti-malarial properties, artemisinins are cytotoxic for cancer cells. The present review focuses on the mechanisms of action of artemisinins in cancer cells relating to: 1. anti-proliferative and anti-angiogenic effects, 2. induction of apoptosis, 3. oxidative stress, 4. oncogenes and tumor suppressor genes, and 5. multidrug resistance. Data on putative target molecules of artemisinins are presented and discussed, e.g. the translationally controlled tumor protein (TCTP). Emphasis is given to pharmacogenomic approaches to analyze the pleiotropic nature of mechanisms of artemisinins in cancer cells.
- Autoren
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/16611029
- DOI
- 10.2174/138945006776359412
- ISSN
- 1389-4501
- Ausgabe der Veröffentlichung
- 4
- Zeitschrift
- Curr Drug Targets
- Schlüsselwörter
- Angiogenesis Inhibitors
- Animals
- Antineoplastic Agents, Phytogenic
- Apoptosis
- Artemisinins
- Cell Line, Tumor
- Cell Proliferation
- Drug Resistance, Neoplasm
- Genes, Tumor Suppressor
- Genetic Engineering
- Humans
- Neoplasms
- Oxidative Stress
- Pharmacogenetics
- Sesquiterpenes
- Tumor Protein, Translationally-Controlled 1
- Sprache
- eng
- Country
- United Arab Emirates
- Paginierung
- 407 - 421
- Datum der Veröffentlichung
- 2006
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2006
- Titel
- Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 7
Data source: PubMed
- Beziehungen:
- Property of