Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi

Publication type:
Journal article
Metadata:
Autoren
  • Michael Adams
  • Thomas Efferth
  • Rudolf Bauer
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000239926000018&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1055/s-2006-947165
eISSN
1439-0221
Externe Identifier
  • Clarivate Analytics Document Solution ID: 075ZG
  • PubMed Identifier: 16881019
ISSN
0032-0943
Ausgabe der Veröffentlichung
9
Zeitschrift
PLANTA MEDICA
Paginierung
862 - 864
Datum der Veröffentlichung
2006
Status
Published
Titel
Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from <i>Artemisia argyi</i>
Sub types
  • Article
Ausgabe der Zeitschrift
72

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Michael Adams
  • Thomas Efferth
  • Rudolf Bauer
DOI
10.1055/s-2006-947165
eISSN
1439-0221
ISSN
0032-0943
Ausgabe der Veröffentlichung
09
Zeitschrift
Planta Medica
Sprache
en
Paginierung
862 - 864
Datum der Veröffentlichung
2006
Status
Published
Herausgeber
Georg Thieme Verlag KG
Herausgeber URL
http://dx.doi.org/10.1055/s-2006-947165
Datum der Datenerfassung
2017
Titel
Activity-Guided Isolation of Scopoletin and Isoscopoletin, the Inhibitory Active Principles towards CCRF-CEM Leukaemia Cells and Multi-Drug Resistant CEM/ADR5000 Cells, from<i>Artemisia argyi</i>
Ausgabe der Zeitschrift
72

Data source: Crossref

Abstract
The ethyl acetate extract of Artemisia argyi leaves showed substantial inhibition in a cell proliferation assay using human CCRF-CEM leukaemia cells. Bioassay-guided fractionation of the extract led to the isolation of scopoletin and isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively. Additionally the two substances were tested against the multidrug resistant subline, CEM/ADR5000 where they both showed IC50 values of 1.6 microM. In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and isoscopoletin.
Addresses
  • Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria.
Autoren
DOI
10.1055/s-2006-947165
eISSN
1439-0221
Externe Identifier
  • PubMed Identifier: 16881019
Open access
false
ISSN
0032-0943
Ausgabe der Veröffentlichung
9
Zeitschrift
Planta medica
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Artemisia
  • Leukemia
  • Scopoletin
  • Drugs, Chinese Herbal
  • Antineoplastic Agents, Phytogenic
  • Chemical Fractionation
  • Cell Proliferation
  • Drug Resistance, Neoplasm
Sprache
eng
Medium
Print
Paginierung
862 - 864
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2006
Titel
Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
72

Data source: Europe PubMed Central

Abstract
The ethyl acetate extract of Artemisia argyi leaves showed substantial inhibition in a cell proliferation assay using human CCRF-CEM leukaemia cells. Bioassay-guided fractionation of the extract led to the isolation of scopoletin and isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively. Additionally the two substances were tested against the multidrug resistant subline, CEM/ADR5000 where they both showed IC50 values of 1.6 microM. In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and isoscopoletin.
Autoren
  • Michael Adams
  • Thomas Efferth
  • Rudolf Bauer
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/16881019
DOI
10.1055/s-2006-947165
ISSN
0032-0943
Ausgabe der Veröffentlichung
9
Zeitschrift
Planta Med
Schlüsselwörter
  • Antineoplastic Agents, Phytogenic
  • Artemisia
  • Cell Line, Tumor
  • Cell Proliferation
  • Chemical Fractionation
  • Drug Resistance, Neoplasm
  • Drugs, Chinese Herbal
  • Humans
  • Leukemia
  • Scopoletin
Sprache
eng
Country
Germany
Paginierung
862 - 864
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2006
Titel
Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
72

Data source: PubMed

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