New glycosides from Tetracentron sinense and their cytotoxic activity

Publication type:
Journal article
Metadata:
Autoren
  • Yi-Fen Wang
  • Gou-Fang Lai
  • Thomas Efferth
  • Jian-Xin Cao
  • Shi-De Luo
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000241317500010&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/cbdv.200690100
eISSN
1612-1880
Externe Identifier
  • Clarivate Analytics Document Solution ID: 095OP
  • PubMed Identifier: 17193335
ISSN
1612-1872
Ausgabe der Veröffentlichung
9
Zeitschrift
CHEMISTRY & BIODIVERSITY
Paginierung
1023 - 1030
Datum der Veröffentlichung
2006
Status
Published
Titel
New glycosides from <i>Tetracentron sinense</i> and their cytotoxic activity
Sub types
  • Article
Ausgabe der Zeitschrift
3

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Yi-Fen Wang
  • Gou-Fang Lai
  • Thomas Efferth
  • Jian-Xin Cao
  • Shi-De Luo
DOI
10.1002/cbdv.200690100
eISSN
1612-1880
ISSN
1612-1872
Ausgabe der Veröffentlichung
9
Zeitschrift
Chemistry &amp; Biodiversity
Sprache
en
Paginierung
1023 - 1030
Datum der Veröffentlichung
2006
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/cbdv.200690100
Datum der Datenerfassung
2021
Titel
New Glycosides fromTetracentron sinense and Their Cytotoxic Activity
Ausgabe der Zeitschrift
3

Data source: Crossref

Abstract
One novel neolignan (tetracentronsine; 1), one new indole alkaloid (=3-(2-hydroxyethyl)-1H-indole-5-O-beta-D-glucopyranoside; 2), and two new phenol derivatives, 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoic acid (3) and methyl 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoate (4), together with six known compounds were isolated from the stem bark of Tetracentron sinense. Their structures were determined by spectral analysis, including 1D- and 2D-NMR, and MS analyses. These compounds were tested for their cytotoxic activity against human leukaemia cells in vitro. Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values in a range of 7.1 to 29.7 microM.
Addresses
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.
Autoren
  • Yi-Fen Wang
  • Gou-Fang Lai
  • Thomas Efferth
  • Thomas Efferth
  • Jian-Xin Cao
  • Shi-De Luo
DOI
10.1002/cbdv.200690100
eISSN
1612-1880
Externe Identifier
  • PubMed Identifier: 17193335
Open access
false
ISSN
1612-1872
Ausgabe der Veröffentlichung
9
Zeitschrift
Chemistry & biodiversity
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Plant Bark
  • Plants, Medicinal
  • Glycosides
  • Plant Extracts
  • Antineoplastic Agents, Phytogenic
  • Drug Screening Assays, Antitumor
  • Cell Proliferation
  • Cell Survival
  • Molecular Structure
  • Structure-Activity Relationship
  • Dose-Response Relationship, Drug
  • Magnoliopsida
Sprache
eng
Medium
Print
Paginierung
1023 - 1030
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2006
Titel
New glycosides from Tetracentron sinense and their cytotoxic activity.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
3

Data source: Europe PubMed Central

Abstract
One novel neolignan (tetracentronsine; 1), one new indole alkaloid (=3-(2-hydroxyethyl)-1H-indole-5-O-beta-D-glucopyranoside; 2), and two new phenol derivatives, 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoic acid (3) and methyl 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoate (4), together with six known compounds were isolated from the stem bark of Tetracentron sinense. Their structures were determined by spectral analysis, including 1D- and 2D-NMR, and MS analyses. These compounds were tested for their cytotoxic activity against human leukaemia cells in vitro. Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values in a range of 7.1 to 29.7 microM.
Autoren
  • Yi-Fen Wang
  • Gou-Fang Lai
  • Thomas Efferth
  • Jian-Xin Cao
  • Shi-De Luo
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17193335
DOI
10.1002/cbdv.200690100
eISSN
1612-1880
Ausgabe der Veröffentlichung
9
Zeitschrift
Chem Biodivers
Schlüsselwörter
  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Glycosides
  • Humans
  • Magnoliopsida
  • Molecular Structure
  • Plant Bark
  • Plant Extracts
  • Plants, Medicinal
  • Structure-Activity Relationship
Sprache
eng
Country
Switzerland
Paginierung
1023 - 1030
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2007
Titel
New glycosides from Tetracentron sinense and their cytotoxic activity.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
3

Data source: PubMed

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