Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN.

Publication type:
Journal article
Metadata:
Autoren
  • Yi-Fen Wang
  • Jian-Xin Cao
  • Thomas Efferth
  • Gou-Fang Lai
  • Shi-De Luo
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000238904600005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/cbdv.200690067
Externe Identifier
  • Clarivate Analytics Document Solution ID: 061WQ
  • PubMed Identifier: 17193298
ISSN
1612-1872
Ausgabe der Veröffentlichung
6
Zeitschrift
CHEMISTRY & BIODIVERSITY
Paginierung
646 - 653
Datum der Veröffentlichung
2006
Status
Published
Titel
Cytotoxic and new tetralone derivatives from <i>Berchemia floribunda</i> (WALL.) BRONGN.
Sub types
  • Article
Ausgabe der Zeitschrift
3

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Yi-Fen Wang
  • Jian-Xin Cao
  • Thomas Efferth
  • Gou-Fang Lai
  • Shi-De Luo
DOI
10.1002/cbdv.200690067
eISSN
1612-1880
ISSN
1612-1872
Ausgabe der Veröffentlichung
6
Zeitschrift
Chemistry &amp; Biodiversity
Sprache
en
Paginierung
646 - 653
Datum der Veröffentlichung
2006
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/cbdv.200690067
Datum der Datenerfassung
2021
Titel
Cytotoxic and New Tetralone Derivatives fromBerchemia floribunda (Wall.)Brongn.
Ausgabe der Zeitschrift
3

Data source: Crossref

Abstract
Two new alpha-tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivatives, berchemiaside A and B (1 and 2, resp.), and one new flavonoid, quercetin-3-O-(2-acetyl-alpha-L-arabinofuranoside (3), together with ten known flavonoids compounds, eriodictyol (4), aromadendrin (5), trans-dihydroquercetin (6), cis-dihydroquercetin (7), kaempferol (8), kaempferol-3-O-alpha-L-arabinofuranoside (9), quercetin (10), quercetin-3-O-alpha-L-arabinofuranoside or avicularin (11), quercetin 3'-methyl ether, 3-O-alpha-L-arabinofuranoside (12), and maesopsin (13), were isolated from the bark of Berchemia floribunda. Their structures were determined by various NMR techniques and chemical studies. Compounds 3-13 were tested for their cytotoxic activity against human leukemia cells. Among them, kaempferol (8) and maesopsin (13) showed significant inhibitory activities against human leukemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC(50) values of 14.0, 5.3, 10.2, and 12.3 microM, respectively.
Addresses
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, PR China.
Autoren
  • Yi-Fen Wang
  • Jian-Xin Cao
  • Thomas Efferth
  • Thomas Efferth
  • Gou-Fang Lai
  • Shi-De Luo
DOI
10.1002/cbdv.200690067
eISSN
1612-1880
Externe Identifier
  • PubMed Identifier: 17193298
Open access
false
ISSN
1612-1872
Ausgabe der Veröffentlichung
6
Zeitschrift
Chemistry & biodiversity
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Rhamnaceae
  • Plant Bark
  • Tetralones
  • Magnetic Resonance Spectroscopy
  • Inhibitory Concentration 50
  • Cell Proliferation
  • Molecular Structure
Sprache
eng
Medium
Print
Paginierung
646 - 653
Datum der Veröffentlichung
2006
Status
Published
Datum der Datenerfassung
2006
Titel
Cytotoxic and new tetralone derivatives from Berchemia floribunda (Wall.) Brongn.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
3

Data source: Europe PubMed Central

Abstract
Two new alpha-tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivatives, berchemiaside A and B (1 and 2, resp.), and one new flavonoid, quercetin-3-O-(2-acetyl-alpha-L-arabinofuranoside (3), together with ten known flavonoids compounds, eriodictyol (4), aromadendrin (5), trans-dihydroquercetin (6), cis-dihydroquercetin (7), kaempferol (8), kaempferol-3-O-alpha-L-arabinofuranoside (9), quercetin (10), quercetin-3-O-alpha-L-arabinofuranoside or avicularin (11), quercetin 3'-methyl ether, 3-O-alpha-L-arabinofuranoside (12), and maesopsin (13), were isolated from the bark of Berchemia floribunda. Their structures were determined by various NMR techniques and chemical studies. Compounds 3-13 were tested for their cytotoxic activity against human leukemia cells. Among them, kaempferol (8) and maesopsin (13) showed significant inhibitory activities against human leukemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC(50) values of 14.0, 5.3, 10.2, and 12.3 microM, respectively.
Autoren
  • Yi-Fen Wang
  • Jian-Xin Cao
  • Thomas Efferth
  • Gou-Fang Lai
  • Shi-De Luo
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17193298
DOI
10.1002/cbdv.200690067
eISSN
1612-1880
Ausgabe der Veröffentlichung
6
Zeitschrift
Chem Biodivers
Schlüsselwörter
  • Cell Line, Tumor
  • Cell Proliferation
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Bark
  • Rhamnaceae
  • Tetralones
Sprache
eng
Country
Switzerland
Paginierung
646 - 653
Datum der Veröffentlichung
2006
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2007
Titel
Cytotoxic and new tetralone derivatives from Berchemia floribunda (Wall.) Brongn.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
3

Data source: PubMed

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