Diagnosis and therapy of oral squamous cell carcinoma

Publication type:
Journal article
Metadata:
Autoren
  • V Badireenath Konkimalla
  • Venkatramana Laxminarayana Suhas
  • Nagasuma R Chandra
  • Erich Gebhart
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000245134900011&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1586/14737140.7.3.317
eISSN
1744-8328
Externe Identifier
  • Clarivate Analytics Document Solution ID: 149GK
  • PubMed Identifier: 17338652
ISSN
1473-7140
Ausgabe der Veröffentlichung
3
Zeitschrift
EXPERT REVIEW OF ANTICANCER THERAPY
Schlüsselwörter
  • comparative genomic hybridization
  • docking studies
  • epidermal growth factor receptor
  • hierarchical cluster analysis
  • modeling
  • molecular-targeted therapy
  • oral squamous cell carcinoma
  • tyrosine kinase inhibitor
Paginierung
317 - 329
Datum der Veröffentlichung
2007
Status
Published
Titel
Diagnosis and therapy of oral squamous cell carcinoma
Sub types
  • Review
Ausgabe der Zeitschrift
7

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • V Badireenath Konkimalla
  • Venkatramana Laxminarayana Suhas
  • Nagasuma R Chandra
  • Erich Gebhart
  • Thomas Efferth
DOI
10.1586/14737140.7.3.317
eISSN
1744-8328
ISSN
1473-7140
Ausgabe der Veröffentlichung
3
Zeitschrift
Expert Review of Anticancer Therapy
Sprache
en
Online publication date
2014
Paginierung
317 - 329
Datum der Veröffentlichung
2007
Status
Published
Herausgeber
Informa UK Limited
Herausgeber URL
http://dx.doi.org/10.1586/14737140.7.3.317
Datum der Datenerfassung
2023
Titel
Diagnosis and therapy of oral squamous cell carcinoma
Ausgabe der Zeitschrift
7

Data source: Crossref

Abstract
Oral squamous cell carcinoma ranks among the top ten most common cancers worldwide. Despite the success in diagnosis and therapy during the past 30 years, oral squamous cell carcinoma still belongs to the tumor types with a very unfavorable prognosis. In an effort to identify genomic alterations with prognostic relevance, we applied the comparative genomic hybridization technique on oral squamous cell carcinoma. The tumors exhibited from five up to 47 DNA copy number alterations, indicating a considerable degree of genomic imbalance. Out of 35 tumors, 19 showed a gain of chromosome band 7p12. Genomic imbalances were investigated by hierarchical cluster analysis and clustered image mapping to investigate whether genomic profiles correlate with clinical data. Results of the present investigation show that profiling of genomic imbalances in general, and especially of the epidermal growth factor receptor (EGFR) on 7p12, may be suitable as prognostic factors. In order to identify small-molecule inhibitors for EGFR, we established a database of 531 natural compounds derived from medicinal plants used in traditional Chinese medicine. Candidate compounds were identified by correlation analysis using the Kendall tau-test of IC50 values of tumor cell lines and microarray-based EGFR mRNA expression. Further validation was performed by molecular docking studies using the AutoDock program with the crystal structure of EGFR tyrosine kinase domain as docking template. We estimate these results will be a further step toward the ultimate goal of individualized, patient-adapted tumor treatment based on tumor molecular profiling.
Addresses
  • German Cancer Research Centre, Pharmaceutical Biology of Natural Products (C015), Heidelberg, Germany.
Autoren
  • V Badireenath Konkimalla
  • Venkatramana Laxminarayana Suhas
  • Nagasuma R Chandra
  • Erich Gebhart
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1586/14737140.7.3.317
eISSN
1744-8328
Externe Identifier
  • PubMed Identifier: 17338652
Open access
false
ISSN
1473-7140
Ausgabe der Veröffentlichung
3
Zeitschrift
Expert review of anticancer therapy
Schlüsselwörter
  • Humans
  • Carcinoma, Squamous Cell
  • Mouth Neoplasms
  • Chromosome Aberrations
  • Azo Compounds
  • Stilbenes
  • Aporphines
  • Berberine
  • Quinazolines
  • Neoplasm Proteins
  • DNA, Neoplasm
  • Drugs, Chinese Herbal
  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • Prognosis
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Risk Factors
  • Gene Expression Profiling
  • Nucleic Acid Hybridization
  • Alcohol Drinking
  • Smoking
  • Age Factors
  • Gene Expression Regulation, Neoplastic
  • Structure-Activity Relationship
  • Polymorphism, Single Nucleotide
  • Genes, erbB-1
  • Databases, Factual
  • ErbB Receptors
  • Erlotinib Hydrochloride
Sprache
eng
Medium
Print
Paginierung
317 - 329
Datum der Veröffentlichung
2007
Status
Published
Datum der Datenerfassung
2007
Titel
Diagnosis and therapy of oral squamous cell carcinoma.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
7

Data source: Europe PubMed Central

Abstract
Oral squamous cell carcinoma ranks among the top ten most common cancers worldwide. Despite the success in diagnosis and therapy during the past 30 years, oral squamous cell carcinoma still belongs to the tumor types with a very unfavorable prognosis. In an effort to identify genomic alterations with prognostic relevance, we applied the comparative genomic hybridization technique on oral squamous cell carcinoma. The tumors exhibited from five up to 47 DNA copy number alterations, indicating a considerable degree of genomic imbalance. Out of 35 tumors, 19 showed a gain of chromosome band 7p12. Genomic imbalances were investigated by hierarchical cluster analysis and clustered image mapping to investigate whether genomic profiles correlate with clinical data. Results of the present investigation show that profiling of genomic imbalances in general, and especially of the epidermal growth factor receptor (EGFR) on 7p12, may be suitable as prognostic factors. In order to identify small-molecule inhibitors for EGFR, we established a database of 531 natural compounds derived from medicinal plants used in traditional Chinese medicine. Candidate compounds were identified by correlation analysis using the Kendall tau-test of IC50 values of tumor cell lines and microarray-based EGFR mRNA expression. Further validation was performed by molecular docking studies using the AutoDock program with the crystal structure of EGFR tyrosine kinase domain as docking template. We estimate these results will be a further step toward the ultimate goal of individualized, patient-adapted tumor treatment based on tumor molecular profiling.
Autoren
  • V Badireenath Konkimalla
  • Venkatramana Laxminarayana Suhas
  • Nagasuma R Chandra
  • Erich Gebhart
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17338652
DOI
10.1586/14737140.7.3.317
eISSN
1744-8328
Ausgabe der Veröffentlichung
3
Zeitschrift
Expert Rev Anticancer Ther
Schlüsselwörter
  • Age Factors
  • Alcohol Drinking
  • Antineoplastic Agents
  • Aporphines
  • Azo Compounds
  • Berberine
  • Carcinoma, Squamous Cell
  • Chromosome Aberrations
  • Crystallography, X-Ray
  • DNA, Neoplasm
  • Databases, Factual
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal
  • ErbB Receptors
  • Erlotinib Hydrochloride
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Genes, erbB-1
  • Humans
  • Mouth Neoplasms
  • Neoplasm Proteins
  • Nucleic Acid Hybridization
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Protein Kinase Inhibitors
  • Quinazolines
  • Risk Factors
  • Smoking
  • Stilbenes
  • Structure-Activity Relationship
Sprache
eng
Country
England
Paginierung
317 - 329
Datum der Veröffentlichung
2007
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2007
Titel
Diagnosis and therapy of oral squamous cell carcinoma.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
7

Data source: PubMed

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