Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy.
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatment. One of these natural products with profound cytotoxicity against tumor cell lines is shikonin from the medicinal plant Lithospermum erythrorhizon. This compound has been selected to demonstrate how molecular determinants of response of tumor cells to Kampo-derived natural products can be investigated by microarray-based approaches. Synthetic or semi-synthetic derivatives of natural products from Kampo medicine may lead to novel drugs with improved features for cancer treatment. Kampo-derived natural products represent a valuable reservoir for individual tumour treatment strategies in the future.
- Addresses
- Division of Toxicology and Cancer Risk Factors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. t.efferth@dkfz.de
- Autoren
- Thomas Efferth
- Hayato Miyachi
- Helmut Bartsch
- eISSN
- 1790-6245
- Externe Identifier
- PubMed Identifier: 17804870
- Open access
- false
- ISSN
- 1109-6535
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Cancer genomics & proteomics
- Schlüsselwörter
- Animals
- Humans
- Neoplasms
- Medicine, Kampo
- Phytotherapy
- Genomics
- Pharmacogenetics
- Japan
- Sprache
- eng
- Medium
- Paginierung
- 81 - 91
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum der Datenerfassung
- 2007
- Titel
- Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 4
Data source: Europe PubMed Central
- Other metadata sources:
-
- Abstract
- In the present review, we give a short introduction into the history, philosophy and traditional diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The main focus is on pharmacogenomics of natural products derived from Kampo medicinal plants, with special emphasis on cancer treatment. One of these natural products with profound cytotoxicity against tumor cell lines is shikonin from the medicinal plant Lithospermum erythrorhizon. This compound has been selected to demonstrate how molecular determinants of response of tumor cells to Kampo-derived natural products can be investigated by microarray-based approaches. Synthetic or semi-synthetic derivatives of natural products from Kampo medicine may lead to novel drugs with improved features for cancer treatment. Kampo-derived natural products represent a valuable reservoir for individual tumour treatment strategies in the future.
- Autoren
- Thomas Efferth
- Hayato Miyachi
- Helmut Bartsch
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/17804870
- ISSN
- 1109-6535
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Cancer Genomics Proteomics
- Schlüsselwörter
- Animals
- Genomics
- Humans
- Japan
- Medicine, Kampo
- Neoplasms
- Pharmacogenetics
- Phytotherapy
- Sprache
- eng
- Country
- Greece
- Paginierung
- 81 - 91
- Datum der Veröffentlichung
- 2007
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2007
- Titel
- Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 4
Data source: PubMed
- Beziehungen:
- Property of