In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated Furocoumarins from Tetradium daniellii

Publication type:
Journal article
Metadata:
Autoren
  • Michael Adams
  • Anne Mahringer
  • Rudolf Bauer
  • Gert Fricker
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000251545000009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1055/s-2007-990261
Externe Identifier
  • Clarivate Analytics Document Solution ID: 239UY
  • PubMed Identifier: 17992628
ISSN
0032-0943
Ausgabe der Veröffentlichung
14
Zeitschrift
PLANTA MEDICA
Paginierung
1475 - 1478
Datum der Veröffentlichung
2007
Status
Published
Titel
<i>In vitro</i> cytotoxicity and P-glycoprotein modulating effects of geranylated Furocoumarins from <i>Tetradium daniellii</i>
Sub types
  • Article
Ausgabe der Zeitschrift
73

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Michael Adams
  • Anne Mahringer
  • Rudolf Bauer
  • Gert Fricker
  • Thomas Efferth
DOI
10.1055/s-2007-990261
eISSN
1439-0221
ISSN
0032-0943
Ausgabe der Veröffentlichung
14
Zeitschrift
Planta Medica
Sprache
en
Paginierung
1475 - 1478
Datum der Veröffentlichung
2007
Status
Published
Herausgeber
Georg Thieme Verlag KG
Herausgeber URL
http://dx.doi.org/10.1055/s-2007-990261
Datum der Datenerfassung
2017
Titel
<i>In vitro</i> Cytotoxicity and P-Glycoprotein Modulating Effects of Geranylated Furocoumarins from <i>Tetradium daniellii</i>
Ausgabe der Zeitschrift
73

Data source: Crossref

Abstract
Four antimycobacterial geranylated furocoumarins, from the fruits of Tetradium daniellii (Rutaceae), were tested in a bioassay using CCRF-CEM leukemia cells and their P-glycoprotein (p-gp) over-expressing subline CEM/ADR5000, to asses their cytotoxicity and effects on cellular efflux pumps. All showed considerable cell proliferation inhibition with IC (50) values ranging from 1.72 to 11.02 microM against CCRF-CEM and 2.09 to 13.56 microM against CEM/ADR5000, respectively. An assay monitoring the p-gp-dependent accumulation of a calcein fluorescent dye in porcine brain capillary endothelial cells was used to study interactions of the test substances with this efflux pump. Here, they all were shown to be only weak to moderate modulators of p-gp. BBB:blood-brain barrier CNS:central nervous system p-gp:P-glycoprotein PBCEC:porcine brain capillary cells.
Addresses
  • Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria.
Autoren
  • Michael Adams
  • Anne Mahringer
  • Rudolf Bauer
  • Gert Fricker
  • Thomas Efferth
  • Thomas Efferth
DOI
10.1055/s-2007-990261
eISSN
1439-0221
Externe Identifier
  • PubMed Identifier: 17992628
Open access
false
ISSN
0032-0943
Ausgabe der Veröffentlichung
14
Zeitschrift
Planta medica
Schlüsselwörter
  • Capillaries
  • Cell Line, Tumor
  • Endothelial Cells
  • Animals
  • Swine
  • Humans
  • Rutaceae
  • Leukemia
  • Antineoplastic Agents, Phytogenic
  • Molecular Structure
  • Furocoumarins
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print-Electronic
Online publication date
2007
Paginierung
1475 - 1478
Datum der Veröffentlichung
2007
Status
Published
Datum der Datenerfassung
2007
Titel
In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated furocoumarins from Tetradium daniellii.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
73

Data source: Europe PubMed Central

Abstract
Four antimycobacterial geranylated furocoumarins, from the fruits of Tetradium daniellii (Rutaceae), were tested in a bioassay using CCRF-CEM leukemia cells and their P-glycoprotein (p-gp) over-expressing subline CEM/ADR5000, to asses their cytotoxicity and effects on cellular efflux pumps. All showed considerable cell proliferation inhibition with IC (50) values ranging from 1.72 to 11.02 microM against CCRF-CEM and 2.09 to 13.56 microM against CEM/ADR5000, respectively. An assay monitoring the p-gp-dependent accumulation of a calcein fluorescent dye in porcine brain capillary endothelial cells was used to study interactions of the test substances with this efflux pump. Here, they all were shown to be only weak to moderate modulators of p-gp. BBB:blood-brain barrier CNS:central nervous system p-gp:P-glycoprotein PBCEC:porcine brain capillary cells.
Autoren
  • Michael Adams
  • Anne Mahringer
  • Rudolf Bauer
  • Gert Fricker
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/17992628
DOI
10.1055/s-2007-990261
ISSN
0032-0943
Ausgabe der Veröffentlichung
14
Zeitschrift
Planta Med
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Capillaries
  • Cell Line, Tumor
  • Endothelial Cells
  • Furocoumarins
  • Humans
  • Leukemia
  • Molecular Structure
  • Rutaceae
  • Swine
Sprache
eng
Country
Germany
Paginierung
1475 - 1478
Datum der Veröffentlichung
2007
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated furocoumarins from Tetradium daniellii.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
73

Data source: PubMed

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