Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Efferth
  • Stefan Kah
  • Kerstin Paulus
  • Michael Adams
  • Rolf Rauh
  • Herbert Boechzelt
  • Xiaojiang Hao
  • Bernd Kaina
  • Rudolf Bauer
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000252580900016&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1158/1535-7163.MCT-07-0073
eISSN
1538-8514
Externe Identifier
  • Clarivate Analytics Document Solution ID: 254IS
  • PubMed Identifier: 18202018
ISSN
1535-7163
Ausgabe der Veröffentlichung
1
Zeitschrift
MOLECULAR CANCER THERAPEUTICS
Paginierung
152 - 161
Datum der Veröffentlichung
2008
Status
Published
Titel
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells
Sub types
  • Article
Ausgabe der Zeitschrift
7

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title> <jats:p>The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone. [Mol Cancer Ther 2008;7(1):152–61]</jats:p>
Autoren
  • Thomas Efferth
  • Stefan Kahl
  • Kerstin Paulus
  • Michael Adams
  • Rolf Rauh
  • Herbert Boechzelt
  • Xiaojiang Hao
  • Bernd Kaina
  • Rudolf Bauer
DOI
10.1158/1535-7163.mct-07-0073
eISSN
1538-8514
ISSN
1535-7163
Ausgabe der Veröffentlichung
1
Zeitschrift
Molecular Cancer Therapeutics
Sprache
en
Online publication date
2008
Paginierung
152 - 161
Datum der Veröffentlichung
2008
Status
Published
Herausgeber
American Association for Cancer Research (AACR)
Herausgeber URL
http://dx.doi.org/10.1158/1535-7163.mct-07-0073
Datum der Datenerfassung
2022
Titel
Phytochemistry and pharmacogenomics of natural products derived from traditional chinese medicine and chinese materia medica with activity against tumor cells
Ausgabe der Zeitschrift
7

Data source: Crossref

Abstract
The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone.
Addresses
  • German Cancer Research Centre, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. t.efferth@dkfz.de
Autoren
  • Thomas Efferth
  • Thomas Efferth
  • Stefan Kahl
  • Kerstin Paulus
  • Michael Adams
  • Rolf Rauh
  • Herbert Boechzelt
  • Xiaojiang Hao
  • Bernd Kaina
  • Rudolf Bauer
DOI
10.1158/1535-7163.mct-07-0073
eISSN
1538-8514
Externe Identifier
  • PubMed Identifier: 18202018
Open access
false
ISSN
1535-7163
Ausgabe der Veröffentlichung
1
Zeitschrift
Molecular cancer therapeutics
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Combretaceae
  • Salvia miltiorrhiza
  • Plant Extracts
  • Drugs, Chinese Herbal
  • Antineoplastic Agents
  • Biological Products
  • Materia Medica
  • Medicine, Chinese Traditional
  • Drug Screening Assays, Antitumor
  • Pharmacogenetics
  • Cell Survival
  • Molecular Structure
Sprache
eng
Medium
Print
Paginierung
152 - 161
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
7

Data source: Europe PubMed Central

Abstract
The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone.
Autoren
  • Thomas Efferth
  • Stefan Kahl
  • Kerstin Paulus
  • Michael Adams
  • Rolf Rauh
  • Herbert Boechzelt
  • Xiaojiang Hao
  • Bernd Kaina
  • Rudolf Bauer
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18202018
DOI
10.1158/1535-7163.MCT-07-0073
ISSN
1535-7163
Ausgabe der Veröffentlichung
1
Zeitschrift
Mol Cancer Ther
Schlüsselwörter
  • Antineoplastic Agents
  • Biological Products
  • Cell Line, Tumor
  • Cell Survival
  • Combretaceae
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal
  • Humans
  • Materia Medica
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Pharmacogenetics
  • Plant Extracts
  • Salvia miltiorrhiza
Sprache
eng
Country
United States
Paginierung
152 - 161
PII
7/1/152
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
7

Data source: PubMed

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