Role of transporter genes in cisplatin resistance

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000256705100002&DestLinkType=FullRecord&DestApp=WOS_CPL
Externe Identifier
  • Clarivate Analytics Document Solution ID: 312XG
  • PubMed Identifier: 18610736
ISSN
0258-851X
Ausgabe der Veröffentlichung
3
Zeitschrift
IN VIVO
Schlüsselwörter
  • ABC transporter
  • cisplatin
  • copper transporter
  • drug resistance
  • microarray
  • pharmacogenomics
Paginierung
279 - 283
Datum der Veröffentlichung
2008
Status
Published
Titel
Role of transporter genes in cisplatin resistance
Sub types
  • Article
Ausgabe der Zeitschrift
22

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
The 50% inhibitory concentration (IC50) values for cisplatin from 60 cell lines of the National Cancer Institute (NCI), USA, were correlated with the microarray-based mRNA expression levels of 55 transporter genes. The transporters are known to be involved in multiple drug resistance and belong to different classes, e.g. lysosomal H+ transporting ATPases, Cu2+ transporting ATPases, glutamate transporters of the solute carrier family 31, copper transporters of the solute carrier family 31, and ATP-binding cassette (ABC) transporter genes. The expression levels of 17 genes represented by 21 clones correlated significantly with the IC50 values for cisplatin. Hierarchical cluster analysis further enabled the prediction of the sensitivity or resistance of these cell lines to cisplatin with respect to the mRNA expression of these set of transporter genes under study. One among the 17 genes studied is ATP7B which is involved in the transport of copper ions across the cell membrane into the cell. We conclude that our microarray-based approach is a feasible and effective tool in identifying prognostic markers for drug resistance in antitumor therapy.
Addresses
  • German Cancer Research Center, Pharmaceutical Biology (C015), Heidelberg.
Autoren
eISSN
1791-7549
Externe Identifier
  • PubMed Identifier: 18610736
Open access
false
ISSN
0258-851X
Ausgabe der Veröffentlichung
3
Zeitschrift
In vivo (Athens, Greece)
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Cisplatin
  • Membrane Transport Proteins
  • RNA, Messenger
  • Oligonucleotide Array Sequence Analysis
  • Gene Expression Regulation, Neoplastic
  • Drug Resistance, Neoplasm
Sprache
eng
Medium
Print
Paginierung
279 - 283
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
Role of transporter genes in cisplatin resistance.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: Europe PubMed Central

Abstract
The 50% inhibitory concentration (IC50) values for cisplatin from 60 cell lines of the National Cancer Institute (NCI), USA, were correlated with the microarray-based mRNA expression levels of 55 transporter genes. The transporters are known to be involved in multiple drug resistance and belong to different classes, e.g. lysosomal H+ transporting ATPases, Cu2+ transporting ATPases, glutamate transporters of the solute carrier family 31, copper transporters of the solute carrier family 31, and ATP-binding cassette (ABC) transporter genes. The expression levels of 17 genes represented by 21 clones correlated significantly with the IC50 values for cisplatin. Hierarchical cluster analysis further enabled the prediction of the sensitivity or resistance of these cell lines to cisplatin with respect to the mRNA expression of these set of transporter genes under study. One among the 17 genes studied is ATP7B which is involved in the transport of copper ions across the cell membrane into the cell. We conclude that our microarray-based approach is a feasible and effective tool in identifying prognostic markers for drug resistance in antitumor therapy.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18610736
ISSN
0258-851X
Ausgabe der Veröffentlichung
3
Zeitschrift
In Vivo
Schlüsselwörter
  • Cell Line, Tumor
  • Cisplatin
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Membrane Transport Proteins
  • Oligonucleotide Array Sequence Analysis
  • RNA, Messenger
Sprache
eng
Country
Greece
Paginierung
279 - 283
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2008
Titel
Role of transporter genes in cisplatin resistance.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
22

Data source: PubMed

Beziehungen:
Property of

Tools