The antiviral activities of artemisinin and artesunate

Publication type:
Journal article
Metadata:
Autoren
  • Thomas Efferth
  • Marta R Romero
  • Dana G Wolf
  • Thomas Stamminger
  • Jose JG Marin
  • Manfred Marschall
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000258570800011&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1086/591195
Externe Identifier
  • Clarivate Analytics Document Solution ID: 339IH
  • PubMed Identifier: 18699744
ISSN
1058-4838
Ausgabe der Veröffentlichung
6
Zeitschrift
CLINICAL INFECTIOUS DISEASES
Paginierung
804 - 811
Datum der Veröffentlichung
2008
Status
Published
Titel
The antiviral activities of artemisinin and artesunate
Sub types
  • Review
Ausgabe der Zeitschrift
47

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Thomas Efferth
  • Marta R Romero
  • Dana G Wolf
  • Thomas Stamminger
  • Jose JG Marin
  • Manfred Marschall
DOI
10.1086/591195
eISSN
1537-6591
ISSN
1058-4838
Ausgabe der Veröffentlichung
6
Zeitschrift
Clinical Infectious Diseases
Sprache
en
Paginierung
804 - 811
Datum der Veröffentlichung
2008
Status
Published
Herausgeber
Oxford University Press (OUP)
Herausgeber URL
http://dx.doi.org/10.1086/591195
Datum der Datenerfassung
2020
Titel
The Antiviral Activities of Artemisinin and Artesunate
Ausgabe der Zeitschrift
47

Data source: Crossref

Abstract
Traditional Chinese medicine commands a unique position among all traditional medicines because of its 5000 years of history. Our own interest in natural products from traditional Chinese medicine was triggered in the 1990s, by artemisinin-type sesquiterpene lactones from Artemisia annua L. As demonstrated in recent years, this class of compounds has activity against malaria, cancer cells, and schistosomiasis. Interestingly, the bioactivity of artemisinin and its semisynthetic derivative artesunate is even broader and includes the inhibition of certain viruses, such as human cytomegalovirus and other members of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus. Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial potential of these versatile pharmacological tools from nature.
Addresses
  • German Cancer Research Center, Pharmaceutical Biology, Im Neuenheimer Feld 280, Heidelberg, Germany. t.efferth@dkfz.de
Autoren
  • Thomas Efferth
  • Thomas Efferth
  • Marta R Romero
  • Dana G Wolf
  • Thomas Stamminger
  • Jose JG Marin
  • Manfred Marschall
DOI
10.1086/591195
eISSN
1537-6591
Externe Identifier
  • PubMed Identifier: 18699744
Open access
false
ISSN
1058-4838
Ausgabe der Veröffentlichung
6
Zeitschrift
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Schlüsselwörter
  • Humans
  • Herpesviridae
  • Cytomegalovirus
  • Hepacivirus
  • HIV-1
  • Artemisinins
  • Antiviral Agents
  • Artesunate
Sprache
eng
Medium
Print
Paginierung
804 - 811
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
The antiviral activities of artemisinin and artesunate.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
47

Data source: Europe PubMed Central

Abstract
Traditional Chinese medicine commands a unique position among all traditional medicines because of its 5000 years of history. Our own interest in natural products from traditional Chinese medicine was triggered in the 1990s, by artemisinin-type sesquiterpene lactones from Artemisia annua L. As demonstrated in recent years, this class of compounds has activity against malaria, cancer cells, and schistosomiasis. Interestingly, the bioactivity of artemisinin and its semisynthetic derivative artesunate is even broader and includes the inhibition of certain viruses, such as human cytomegalovirus and other members of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus. Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial potential of these versatile pharmacological tools from nature.
Autoren
  • Thomas Efferth
  • Marta R Romero
  • Dana G Wolf
  • Thomas Stamminger
  • Jose JG Marin
  • Manfred Marschall
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/18699744
DOI
10.1086/591195
eISSN
1537-6591
Ausgabe der Veröffentlichung
6
Zeitschrift
Clin Infect Dis
Schlüsselwörter
  • Antiviral Agents
  • Artemisinins
  • Artesunate
  • Cytomegalovirus
  • HIV-1
  • Hepacivirus
  • Herpesviridae
  • Humans
Sprache
eng
Country
United States
Paginierung
804 - 811
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
The antiviral activities of artemisinin and artesunate.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
47

Data source: PubMed

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