Human cytomegalovirus: Drug resistance and new treatment options using natural products
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Silviya Stoeva
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000261058300002&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3892/mmr_00000028
- eISSN
- 1791-3004
- Externe Identifier
- Clarivate Analytics Document Solution ID: 374QH
- PubMed Identifier: 21479485
- ISSN
- 1791-2997
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- MOLECULAR MEDICINE REPORTS
- Schlüsselwörter
- antiviral agents
- chemotherapy
- drug resistance
- human cytomegalovirus
- natural products
- pharmacognosy
- Paginierung
- 781 - 785
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Titel
- Human cytomegalovirus: Drug resistance and new treatment options using natural products
- Sub types
- Article
- Ausgabe der Zeitschrift
- 1
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- DOI
- 10.3892/mmr_00000028
- ISSN
- 1791-2997
- Zeitschrift
- Molecular Medicine Reports
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Herausgeber
- Spandidos Publications
- Herausgeber URL
- http://dx.doi.org/10.3892/mmr_00000028
- Datum der Datenerfassung
- 2017
- Titel
- Human cytomegalovirus: Drug resistance and new treatment options using natural products
Data source: Crossref
- Abstract
- Human cytomegalovirus (HCMV), a member of the β-herpesvirus family, is a cause of high morbidity and mortality rates among immunosuppressed individuals and patients with acquired immunodeficiency syndrome (AIDS). Despite the availability of approved antiviral drugs, treatment of HCMV infections remains difficult. Antiviral therapies are in part limited by the small number of available drugs showing satisfactory clinical results. Other factors, such as low potency, poor oral bioavailability and the emergence of drug resistance, also contribute significantly to the obstacles confronting current therapies for HCMV infection. In search of new drugs for the treatment of HCMV infection, researchers have turned their attention to natural products. Unfortunately, not many natural compounds have proven to be efficacious against HCMV. Those that have shown good results in vitro are reviewed here, and their molecular targets and mechanisms of action are discussed along with those of established antiviral agents.
- Addresses
- University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, 69120 Heidelberg, Germany.
- Autoren
- Silviya Stoeva
- Thomas Efferth
- DOI
- 10.3892/mmr_00000028
- eISSN
- 1791-3004
- Externe Identifier
- PubMed Identifier: 21479485
- Open access
- false
- ISSN
- 1791-2997
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Molecular medicine reports
- Sprache
- eng
- Medium
- Paginierung
- 781 - 785
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum der Datenerfassung
- 2011
- Titel
- Human cytomegalovirus: Drug resistance and new treatment options using natural products.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 1
Data source: Europe PubMed Central
- Abstract
- Human cytomegalovirus (HCMV), a member of the β-herpesvirus family, is a cause of high morbidity and mortality rates among immunosuppressed individuals and patients with acquired immunodeficiency syndrome (AIDS). Despite the availability of approved antiviral drugs, treatment of HCMV infections remains difficult. Antiviral therapies are in part limited by the small number of available drugs showing satisfactory clinical results. Other factors, such as low potency, poor oral bioavailability and the emergence of drug resistance, also contribute significantly to the obstacles confronting current therapies for HCMV infection. In search of new drugs for the treatment of HCMV infection, researchers have turned their attention to natural products. Unfortunately, not many natural compounds have proven to be efficacious against HCMV. Those that have shown good results in vitro are reviewed here, and their molecular targets and mechanisms of action are discussed along with those of established antiviral agents.
- Autoren
- Silviya Stoeva
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/21479485
- DOI
- 10.3892/mmr_00000028
- ISSN
- 1791-2997
- Ausgabe der Veröffentlichung
- 6
- Zeitschrift
- Mol Med Rep
- Sprache
- eng
- Country
- Greece
- Paginierung
- 781 - 785
- Datum der Veröffentlichung
- 2008
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2012
- Titel
- Human cytomegalovirus: Drug resistance and new treatment options using natural products.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 1
Data source: PubMed
- Beziehungen:
- Property of