The role of copper in drug-resistant murine and human tumors
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- S Majumder
- S Chatterjee
- Smarajit Pal
- J Biswas
- T Efferth
- Soumitra Kumar Choudhuri
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000264546600019&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1007/s10534-008-9174-3
- eISSN
- 1572-8773
- Externe Identifier
- Clarivate Analytics Document Solution ID: 424DV
- PubMed Identifier: 18956143
- ISSN
- 0966-0844
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- BIOMETALS
- Schlüsselwörter
- Biomarker
- Copper
- Multidrug resistance
- Serum copper
- Paginierung
- 377 - 384
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Titel
- The role of copper in drug-resistant murine and human tumors
- Sub types
- Article
- Ausgabe der Zeitschrift
- 22
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- S Majumder
- S Chatterjee
- Smarajit Pal
- J Biswas
- T Efferth
- Soumitra Kumar Choudhuri
- DOI
- 10.1007/s10534-008-9174-3
- eISSN
- 1572-8773
- ISSN
- 0966-0844
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- BioMetals
- Sprache
- en
- Online publication date
- 2008
- Paginierung
- 377 - 384
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s10534-008-9174-3
- Datum der Datenerfassung
- 2021
- Titel
- The role of copper in drug-resistant murine and human tumors
- Ausgabe der Zeitschrift
- 22
Data source: Crossref
- Abstract
- Multidrug resistance (MDR) is still a major threat to successful clinical application of cancer chemotherapy. Copper plays an important role in biological systems, and copper is also involved in carcinogenesis. In the present investigation, we addressed the question whether metal copper might be involved in drug resistance of murine and human tumors. By means of atomic absorption spectroscopy, we determined serum copper concentrations. We found that the blood serum of tumor-bearing mice contained higher amounts of copper than healthy mice with tumors. Secondly, mice bearing doxorubicin-resistant Ehrlich ascites carcinoma- or cyclophosphamide-resistant Lewis lung carcinoma contained more copper in their serum than mice bearing the corresponding drug-sensitive parental tumors. Furthermore, the analysis of patients with breast cancer, colon carcinoma or lung cancer showed that the serum copper contents were higher in patients not responding to chemotherapy when compared to patients whose tumors responded to treatment. The copper levels in serum of healthy volunteers were lower than in cancer patients irrespective of their response to chemotherapy. Our results imply that the level of serum copper may be considered as a biomarker for treatment response.
- Addresses
- Department of In-Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkatta, 700 026, India.
- Autoren
- S Majumder
- S Chatterjee
- Smarajit Pal
- J Biswas
- T Efferth
- T Efferth
- Soumitra Kumar Choudhuri
- DOI
- 10.1007/s10534-008-9174-3
- eISSN
- 1572-8773
- Externe Identifier
- PubMed Identifier: 18956143
- Open access
- false
- ISSN
- 0966-0844
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Mice, Inbred C57BL
- Humans
- Mice
- Neoplasms
- Copper
- Neoplasm Transplantation
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Adult
- Aged
- Middle Aged
- Female
- Male
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2008
- Paginierung
- 377 - 384
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Datum der Datenerfassung
- 2008
- Titel
- The role of copper in drug-resistant murine and human tumors.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 22
Data source: Europe PubMed Central
- Abstract
- Multidrug resistance (MDR) is still a major threat to successful clinical application of cancer chemotherapy. Copper plays an important role in biological systems, and copper is also involved in carcinogenesis. In the present investigation, we addressed the question whether metal copper might be involved in drug resistance of murine and human tumors. By means of atomic absorption spectroscopy, we determined serum copper concentrations. We found that the blood serum of tumor-bearing mice contained higher amounts of copper than healthy mice with tumors. Secondly, mice bearing doxorubicin-resistant Ehrlich ascites carcinoma- or cyclophosphamide-resistant Lewis lung carcinoma contained more copper in their serum than mice bearing the corresponding drug-sensitive parental tumors. Furthermore, the analysis of patients with breast cancer, colon carcinoma or lung cancer showed that the serum copper contents were higher in patients not responding to chemotherapy when compared to patients whose tumors responded to treatment. The copper levels in serum of healthy volunteers were lower than in cancer patients irrespective of their response to chemotherapy. Our results imply that the level of serum copper may be considered as a biomarker for treatment response.
- Date of acceptance
- 2008
- Autoren
- S Majumder
- S Chatterjee
- Smarajit Pal
- J Biswas
- T Efferth
- Soumitra Kumar Choudhuri
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/18956143
- DOI
- 10.1007/s10534-008-9174-3
- eISSN
- 1572-8773
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Biometals
- Schlüsselwörter
- Adult
- Aged
- Animals
- Cell Line, Tumor
- Copper
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Female
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Neoplasm Transplantation
- Neoplasms
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 377 - 384
- Datum der Veröffentlichung
- 2009
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2009
- Titel
- The role of copper in drug-resistant murine and human tumors.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 22
Data source: PubMed
- Beziehungen:
- Property of