Molecular Mechanisms Underlying St. John's Wort Drug Interactions

Publication type:
Journal article
Metadata:
Autoren
  • Maike Kober
  • Kerstin Pohl
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000263289500005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/138920008786927767
eISSN
1875-5453
Externe Identifier
  • Clarivate Analytics Document Solution ID: 406IZ
  • PubMed Identifier: 19075619
ISSN
1389-2002
Ausgabe der Veröffentlichung
10
Zeitschrift
CURRENT DRUG METABOLISM
Schlüsselwörter
  • St. John's wort (SJW)
  • drug interactions
  • chemotherapy
  • PXR activation
  • CYP induction
  • Pgp induction
  • photophysical diagnosis (PPD)
  • photodynamic therapy (PDT)
Paginierung
1027 - 1037
Datum der Veröffentlichung
2008
Status
Published
Titel
Molecular Mechanisms Underlying St. John's Wort Drug Interactions
Sub types
  • Review
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Maike Kober
  • Kerstin Pohl
  • Thomas Efferth
DOI
10.2174/138920008786927767
ISSN
1389-2002
Ausgabe der Veröffentlichung
10
Zeitschrift
Current Drug Metabolism
Sprache
en
Paginierung
1027 - 1037
Datum der Veröffentlichung
2008
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/138920008786927767
Datum der Datenerfassung
2015
Titel
Molecular Mechanisms Underlying St. Johns Wort Drug Interactions
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
The phytopharmaceutical agent St. John's wort (SJW) is currently under intense investigation. Studies of drug interactions resulting from concomitant use of SJW and conventional medication are of fundamental importance, since the use of SJW as a complementary and alternative medicine is highly popular. Intake of SJW often remains unrecognized by physicians resulting in clinical relevant alterations of treatment, as this phytopharmaceutical agent is available without prescription. This review elicits molecular explanations for clinical observations in terms of concomitant use of SJW and conventional drugs. Since patients suffering from severe diseases such as cancer are especially at risk, we focus on chemotherapeutic agents. There is strong evidence that SJW extract lowers drug plasma levels of various anti-cancer agents by pregnane X receptor activation resulting in induction of cytochrome P450 isotype 3A4, P glycoprotein and several other enzymes. New methods such as photophysical diagnosis (PPD) and photodynamic therapy (PDT) seem to be highly promising with respect to their clinical application. Due to its fluorescent activity and an intense accumulation in cancer cells, hypericin could be applied to locate tumorous tissues. Upon excitation by light, hypericin generates cytotoxic products rendering its use attractive as photosensitizing agent. In this review both PPD and PDT are explained in detail, with a particular focus on molecular mechanisms.
Addresses
  • Institute of Pharmacy and Molecular Biotechnology, Ruprecht Karls University, Heidelberg, Germany.
Autoren
DOI
10.2174/138920008786927767
eISSN
1875-5453
Externe Identifier
  • PubMed Identifier: 19075619
Open access
false
ISSN
1389-2002
Ausgabe der Veröffentlichung
10
Zeitschrift
Current drug metabolism
Schlüsselwörter
  • Animals
  • Humans
  • Hypericum
  • Anthracenes
  • Perylene
  • Antineoplastic Agents
  • Photochemotherapy
  • Enzyme Induction
  • Herb-Drug Interactions
  • Cytochrome P-450 CYP3A
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print
Paginierung
1027 - 1037
Datum der Veröffentlichung
2008
Status
Published
Datum der Datenerfassung
2008
Titel
Molecular mechanisms underlying St. John's wort drug interactions.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: Europe PubMed Central

Abstract
The phytopharmaceutical agent St. John's wort (SJW) is currently under intense investigation. Studies of drug interactions resulting from concomitant use of SJW and conventional medication are of fundamental importance, since the use of SJW as a complementary and alternative medicine is highly popular. Intake of SJW often remains unrecognized by physicians resulting in clinical relevant alterations of treatment, as this phytopharmaceutical agent is available without prescription. This review elicits molecular explanations for clinical observations in terms of concomitant use of SJW and conventional drugs. Since patients suffering from severe diseases such as cancer are especially at risk, we focus on chemotherapeutic agents. There is strong evidence that SJW extract lowers drug plasma levels of various anti-cancer agents by pregnane X receptor activation resulting in induction of cytochrome P450 isotype 3A4, P glycoprotein and several other enzymes. New methods such as photophysical diagnosis (PPD) and photodynamic therapy (PDT) seem to be highly promising with respect to their clinical application. Due to its fluorescent activity and an intense accumulation in cancer cells, hypericin could be applied to locate tumorous tissues. Upon excitation by light, hypericin generates cytotoxic products rendering its use attractive as photosensitizing agent. In this review both PPD and PDT are explained in detail, with a particular focus on molecular mechanisms.
Autoren
  • Maike Kober
  • Kerstin Pohl
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19075619
DOI
10.2174/138920008786927767
ISSN
1389-2002
Ausgabe der Veröffentlichung
10
Zeitschrift
Curr Drug Metab
Schlüsselwörter
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Animals
  • Anthracenes
  • Antineoplastic Agents
  • Cytochrome P-450 CYP3A
  • Enzyme Induction
  • Herb-Drug Interactions
  • Humans
  • Hypericum
  • Perylene
  • Photochemotherapy
Sprache
eng
Country
Netherlands
Paginierung
1027 - 1037
Datum der Veröffentlichung
2008
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Molecular mechanisms underlying St. John's wort drug interactions.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
9

Data source: PubMed

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