Natural products as promising drug candidates for the treatment of hepatitis B and C

Publication type:
Journal article
Metadata:
Autoren
  • Carolin Wohlfarth
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000262606900002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1038/aps.2008.5
eISSN
1745-7254
Externe Identifier
  • Clarivate Analytics Document Solution ID: 396QT
  • PubMed Identifier: 19060918
ISSN
1671-4083
Ausgabe der Veröffentlichung
1
Zeitschrift
ACTA PHARMACOLOGICA SINICA
Schlüsselwörter
  • antiviral agent
  • chemotherapy
  • drug resistance
  • hepatitis B
  • hepatitis C
  • natural product
  • pharmacognosy
Paginierung
25 - 30
Datum der Veröffentlichung
2009
Status
Published
Titel
Natural products as promising drug candidates for the treatment of hepatitis B and C
Sub types
  • Review
Ausgabe der Zeitschrift
30

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Carolin Wohlfarth
  • Thomas Efferth
DOI
10.1038/aps.2008.5
eISSN
1745-7254
ISSN
1671-4083
Ausgabe der Veröffentlichung
1
Zeitschrift
Acta Pharmacologica Sinica
Sprache
en
Online publication date
2008
Paginierung
25 - 30
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Springer Science and Business Media LLC
Herausgeber URL
http://dx.doi.org/10.1038/aps.2008.5
Datum der Datenerfassung
2023
Titel
Natural products as promising drug candidates for the treatment of hepatitis B and C
Ausgabe der Zeitschrift
30

Data source: Crossref

Abstract
Hepatitis B virus (HBV) or hepatitis C virus (HCV) infections are a major threat worldwide. Combination therapy of interferon-alpha and ribavirin is currently the treatment of choice for HCV-infected patients. However, this regimen is only effective in approximately 50% of patients and provokes severe side-effects. Numerous natural alternatives for treating HCV have been suggested. Deoxynojirimycin and its derivatives are iminosugars which exert anti-HCV activity by inhibiting alpha-glucosidases. A non-immunosuppressive derivate of cyclosporine A, NIM811, exerts anti-HCV activity by binding to cyclophilin. Other natural products with promising anti-HCV activity are 2-arylbenzofuran derivatives, Mellein, and pseudoguaianolides. For HBV treatment, several drugs are available, specifically targeting the virus polymerase (lamivudine, entecavir, telbivudine, and adefovir dipivoxil). The efficacy of these drugs is hampered by the development of resistance due to point mutations in the HBV polymerase. Due to drug resistance and adverse side-effects, the search for novel drugs is mandatory. Wogonin, ellagic acid, artemisinin and artesunate, chrysophanol 8-O-beta-D-glucoside, saikosaponin C, and protostane triterpenes are active against HBV. Natural products need to be investigated in more detail to explore their potential as novel adjuncts to established HBV or HCV therapy.
Addresses
  • University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Germany.
Autoren
DOI
10.1038/aps.2008.5
eISSN
1745-7254
Externe Identifier
  • PubMed Identifier: 19060918
  • PubMed Central ID: PMC4006527
Open access
false
ISSN
1671-4083
Ausgabe der Veröffentlichung
1
Zeitschrift
Acta pharmacologica Sinica
Schlüsselwörter
  • Humans
  • Hepatitis B virus
  • Hepacivirus
  • Hepatitis B
  • Hepatitis C
  • Liver Diseases
  • Biological Products
  • Antiviral Agents
Sprache
eng
Medium
Print-Electronic
Online publication date
2008
Paginierung
25 - 30
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2008
Titel
Natural products as promising drug candidates for the treatment of hepatitis B and C.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
30

Files

https://www.nature.com/articles/aps20085.pdf https://europepmc.org/articles/PMC4006527?pdf=render

Data source: Europe PubMed Central

Abstract
Hepatitis B virus (HBV) or hepatitis C virus (HCV) infections are a major threat worldwide. Combination therapy of interferon-alpha and ribavirin is currently the treatment of choice for HCV-infected patients. However, this regimen is only effective in approximately 50% of patients and provokes severe side-effects. Numerous natural alternatives for treating HCV have been suggested. Deoxynojirimycin and its derivatives are iminosugars which exert anti-HCV activity by inhibiting alpha-glucosidases. A non-immunosuppressive derivate of cyclosporine A, NIM811, exerts anti-HCV activity by binding to cyclophilin. Other natural products with promising anti-HCV activity are 2-arylbenzofuran derivatives, Mellein, and pseudoguaianolides. For HBV treatment, several drugs are available, specifically targeting the virus polymerase (lamivudine, entecavir, telbivudine, and adefovir dipivoxil). The efficacy of these drugs is hampered by the development of resistance due to point mutations in the HBV polymerase. Due to drug resistance and adverse side-effects, the search for novel drugs is mandatory. Wogonin, ellagic acid, artemisinin and artesunate, chrysophanol 8-O-beta-D-glucoside, saikosaponin C, and protostane triterpenes are active against HBV. Natural products need to be investigated in more detail to explore their potential as novel adjuncts to established HBV or HCV therapy.
Autoren
  • Carolin Wohlfarth
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19060918
DOI
10.1038/aps.2008.5
eISSN
1745-7254
Externe Identifier
  • PubMed Central ID: PMC4006527
Ausgabe der Veröffentlichung
1
Zeitschrift
Acta Pharmacol Sin
Schlüsselwörter
  • Antiviral Agents
  • Biological Products
  • Hepacivirus
  • Hepatitis B
  • Hepatitis B virus
  • Hepatitis C
  • Humans
  • Liver Diseases
Sprache
eng
Country
United States
Paginierung
25 - 30
PII
aps20085
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Natural products as promising drug candidates for the treatment of hepatitis B and C.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
30

Data source: PubMed

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