Drug Resistance in Plasmodium: Natural Products in the Fight Against Malaria

Publication type:
Journal article
Metadata:
Autoren
  • Simon Turschner
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000263977200006&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/138955709787316074
eISSN
1875-5607
Externe Identifier
  • Clarivate Analytics Document Solution ID: 416AI
  • PubMed Identifier: 19200025
ISSN
1389-5575
Ausgabe der Veröffentlichung
2
Zeitschrift
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Schlüsselwörter
  • Artemisinin
  • chemotherapy
  • drug resistance
  • malaria
  • natural products
  • pharmacognosy
  • Plasmodium falciparum
Paginierung
206 - 214
Datum der Veröffentlichung
2009
Status
Published
Titel
Drug Resistance in <i>Plasmodium</i>: Natural Products in the Fight Against Malaria
Sub types
  • Review
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Simon Turschner
  • Thomas Efferth
DOI
10.2174/138955709787316074
ISSN
1389-5575
Ausgabe der Veröffentlichung
2
Zeitschrift
Mini-Reviews in Medicinal Chemistry
Sprache
en
Paginierung
206 - 214
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/138955709787316074
Datum der Datenerfassung
2015
Titel
Drug Resistance in Plasmodium: Natural Products in the Fight Against Malaria
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
Malaria, perhaps one of the most serious and widespread diseases encountered by mankind, continues to be a major threat to about 40 % of the world's population, especially in the developing world. As malaria vaccines remain problematic, chemotherapy still is the most important weapon in the fight against the disease. However, almost all available drugs have been compromised by the highly adaptable parasite, and the increasing drug resistance of Plasmodium falciparum continues to be the main problem. Therefore, the limited clinical repertoire of effective drugs and the emergence of multi-resistant strains substantiate the need for new anti-malarials. Plant-derived artemisinin is currently the only available drug that is globally effective, but alarmingly, recent studies suggest that resistance already may be developing. Nevertheless, the success story of artemisinin from the herb Qing Hao (Artemisia annua L.), used as a remedy in traditional Chinese medicine for more than two thousand years, shows once again that natural products serve as an invaluable reservoir of lead compounds for sophisticated small molecules. This review outlines the major anti-malarials, summarizing recent knowledge about their mode of action and the development of drug resistance. Furthermore, the most promising and recently discovered natural products with anti-malarial potential will be introduced.
Addresses
  • German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Autoren
DOI
10.2174/138955709787316074
eISSN
1875-5607
Externe Identifier
  • PubMed Identifier: 19200025
Open access
false
ISSN
1389-5575
Ausgabe der Veröffentlichung
2
Zeitschrift
Mini reviews in medicinal chemistry
Schlüsselwörter
  • Animals
  • Humans
  • Plasmodium
  • Malaria
  • Biological Products
  • Antimalarials
  • Drug Resistance
Sprache
eng
Medium
Print
Paginierung
206 - 2124
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Drug resistance in Plasmodium: natural products in the fight against malaria.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: Europe PubMed Central

Abstract
Malaria, perhaps one of the most serious and widespread diseases encountered by mankind, continues to be a major threat to about 40 % of the world's population, especially in the developing world. As malaria vaccines remain problematic, chemotherapy still is the most important weapon in the fight against the disease. However, almost all available drugs have been compromised by the highly adaptable parasite, and the increasing drug resistance of Plasmodium falciparum continues to be the main problem. Therefore, the limited clinical repertoire of effective drugs and the emergence of multi-resistant strains substantiate the need for new anti-malarials. Plant-derived artemisinin is currently the only available drug that is globally effective, but alarmingly, recent studies suggest that resistance already may be developing. Nevertheless, the success story of artemisinin from the herb Qing Hao (Artemisia annua L.), used as a remedy in traditional Chinese medicine for more than two thousand years, shows once again that natural products serve as an invaluable reservoir of lead compounds for sophisticated small molecules. This review outlines the major anti-malarials, summarizing recent knowledge about their mode of action and the development of drug resistance. Furthermore, the most promising and recently discovered natural products with anti-malarial potential will be introduced.
Autoren
  • Simon Turschner
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19200025
DOI
10.2174/138955709787316074
ISSN
1389-5575
Ausgabe der Veröffentlichung
2
Zeitschrift
Mini Rev Med Chem
Schlüsselwörter
  • Animals
  • Antimalarials
  • Biological Products
  • Drug Resistance
  • Humans
  • Malaria
  • Plasmodium
Sprache
eng
Country
Netherlands
Paginierung
206 - 2124
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Drug resistance in Plasmodium: natural products in the fight against malaria.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
9

Data source: PubMed

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