Molecular principles of cancer invasion and metastasis (Review)

Publication type:
Journal article
Metadata:
Autoren
  • Mathias Felix Leber
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000264661100001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3892/ijo_00000214
eISSN
1791-2423
Externe Identifier
  • Clarivate Analytics Document Solution ID: 425TW
  • PubMed Identifier: 19287945
ISSN
1019-6439
Ausgabe der Veröffentlichung
4
Zeitschrift
INTERNATIONAL JOURNAL OF ONCOLOGY
Schlüsselwörter
  • apoptosis
  • cancer
  • invasion
  • metastasis
  • neoangiogenesis
  • signal transduction
Paginierung
881 - 895
Datum der Veröffentlichung
2009
Status
Published
Titel
Molecular principles of cancer invasion and metastasis (Review)
Sub types
  • Article
Ausgabe der Zeitschrift
34

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.3892/ijo_00000214
ISSN
1019-6439
Ausgabe der Veröffentlichung
4
Zeitschrift
International Journal of Oncology
Datum der Veröffentlichung
2009
Status
Published
Herausgeber
Spandidos Publications
Herausgeber URL
http://dx.doi.org/10.3892/ijo_00000214
Datum der Datenerfassung
2017
Titel
Molecular principles of cancer invasion and metastasis (Review)
Ausgabe der Zeitschrift
34

Data source: Crossref

Abstract
The main threat and the reason for most cancer deaths are not the primary neoplasias, but secondary tumors, the metastases. Drastic phenotypic and biochemical changes occur during the metamorphosis of a normal tissue cell into an invasive cancer cell. These alterations concern various areas such as growth factor signaling, cell-cell adhesion, gene expression, motility or cell shape. Cancer cells of epithelial origin can even shed their typical qualities and characteristics and adopt a mesenchymal-like phenotype. This is often referred to as an epithelial-mesenchymal transition. Various oncogenes, tumor suppressor genes and metastasis suppressor genes are known to affect the invasiveness and the metastatic potential of tumor cells. Cells of the innate and adaptive immunity, adjacent stroma cells as well as chemokines and their receptors also play a vital role in the spread of cancer cells. Furthermore, the micro-environment, vascularization and the supply with special cytokines affect the above-mentioned changes. Finally, some researchers claim that tumors consist of two types of cells - transit amplifying cells and cancer stem cells. Only the latter are thought to be able to proliferate indefinitely and thus they might be the cells that successfully spread and initially build most of the clinically relevant metastases. This review article describes some of the molecular principles which underlie those changes as well as covers some aspects of current research.
Addresses
  • University of Mainz, Mainz, Germany.
Autoren
DOI
10.3892/ijo_00000214
eISSN
1791-2423
Externe Identifier
  • PubMed Identifier: 19287945
Open access
false
ISSN
1019-6439
Ausgabe der Veröffentlichung
4
Zeitschrift
International journal of oncology
Schlüsselwörter
  • Humans
  • Neoplasms
  • Cell Transformation, Neoplastic
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Cytokines
  • Cell Adhesion
  • Signal Transduction
  • Cell Proliferation
  • Cell Movement
  • Cell Shape
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Models, Biological
Sprache
eng
Medium
Print
Paginierung
881 - 895
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Molecular principles of cancer invasion and metastasis (review).
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
34

Data source: Europe PubMed Central

Abstract
The main threat and the reason for most cancer deaths are not the primary neoplasias, but secondary tumors, the metastases. Drastic phenotypic and biochemical changes occur during the metamorphosis of a normal tissue cell into an invasive cancer cell. These alterations concern various areas such as growth factor signaling, cell-cell adhesion, gene expression, motility or cell shape. Cancer cells of epithelial origin can even shed their typical qualities and characteristics and adopt a mesenchymal-like phenotype. This is often referred to as an epithelial-mesenchymal transition. Various oncogenes, tumor suppressor genes and metastasis suppressor genes are known to affect the invasiveness and the metastatic potential of tumor cells. Cells of the innate and adaptive immunity, adjacent stroma cells as well as chemokines and their receptors also play a vital role in the spread of cancer cells. Furthermore, the micro-environment, vascularization and the supply with special cytokines affect the above-mentioned changes. Finally, some researchers claim that tumors consist of two types of cells - transit amplifying cells and cancer stem cells. Only the latter are thought to be able to proliferate indefinitely and thus they might be the cells that successfully spread and initially build most of the clinically relevant metastases. This review article describes some of the molecular principles which underlie those changes as well as covers some aspects of current research.
Autoren
  • Mathias Felix Leber
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19287945
DOI
10.3892/ijo_00000214
ISSN
1019-6439
Ausgabe der Veröffentlichung
4
Zeitschrift
Int J Oncol
Schlüsselwörter
  • Cell Adhesion
  • Cell Movement
  • Cell Proliferation
  • Cell Shape
  • Cell Transformation, Neoplastic
  • Cytokines
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Humans
  • Models, Biological
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms
  • Signal Transduction
Sprache
eng
Country
Greece
Paginierung
881 - 895
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Molecular principles of cancer invasion and metastasis (review).
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
34

Data source: PubMed

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