Detection and Characterization of a Glutathione Conjugate of a Novel Copper Complex

Publication type:
Journal article
Metadata:
Autoren
  • Soumya Basu
  • S Majumder
  • S Chatterjee
  • A Ganguly
  • T Efferth
  • SK Choudhuri
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000266324800005&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1791-7549
Externe Identifier
  • Clarivate Analytics Document Solution ID: 449IT
  • PubMed Identifier: 19454505
ISSN
0258-851X
Ausgabe der Veröffentlichung
3
Zeitschrift
IN VIVO
Schlüsselwörter
  • Conjugate
  • copper (II) (N-2-hydroxyacetophenone) glycinate
  • glutathione (GSH)
  • glutathione-S-transferase (GST)
Paginierung
401 - 408
Datum der Veröffentlichung
2009
Status
Published
Titel
Detection and Characterization of a Glutathione Conjugate of a Novel Copper Complex
Sub types
  • Article
Ausgabe der Zeitschrift
23

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
Glutathione (GSH), an important component of the phase II detoxification system, plays a major role in storage, metabolism and transport of metals across the cell membrane. The role of copper, its metabolism and storage in living systems is not completely understood. Copper plays an important role in a number of physiological processes, e.g. several growth and transcription factors require copper for activity. In the present investigation, we focused on copper (II) (N-2-hydroxyacetophenone) glycinate (CuNG), a novel in vitro and in vivo resistance modifying agent. A conjugate of GSH and CuNG was detected in vivo in mice and was characterized by spectroscopic studies. Based on UV, IR, proton NMR and elemental analyses, the chemical structure of the conjugate was elucidated. By means of atomic absorption data, the distribution and metabolism of CuNG is described.
Addresses
  • Department of In-vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Calcutta-700 026, India.
Autoren
  • Soumya Basu
  • S Majumder
  • S Chatterjee
  • A Ganguly
  • T Efferth
  • SK Choudhuri
eISSN
1791-7549
Externe Identifier
  • PubMed Identifier: 19454505
Open access
false
ISSN
0258-851X
Ausgabe der Veröffentlichung
3
Zeitschrift
In vivo (Athens, Greece)
Schlüsselwörter
  • Animals
  • Mice
  • Copper
  • Glutathione
  • Chromatography, Liquid
  • Spectrum Analysis
  • Models, Molecular
  • Male
Sprache
eng
Medium
Print
Paginierung
401 - 408
Datum der Veröffentlichung
2009
Status
Published
Datum der Datenerfassung
2009
Titel
Detection and characterization of a glutathione conjugate of a novel copper complex.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
23

Data source: Europe PubMed Central

Abstract
Glutathione (GSH), an important component of the phase II detoxification system, plays a major role in storage, metabolism and transport of metals across the cell membrane. The role of copper, its metabolism and storage in living systems is not completely understood. Copper plays an important role in a number of physiological processes, e.g. several growth and transcription factors require copper for activity. In the present investigation, we focused on copper (II) (N-2-hydroxyacetophenone) glycinate (CuNG), a novel in vitro and in vivo resistance modifying agent. A conjugate of GSH and CuNG was detected in vivo in mice and was characterized by spectroscopic studies. Based on UV, IR, proton NMR and elemental analyses, the chemical structure of the conjugate was elucidated. By means of atomic absorption data, the distribution and metabolism of CuNG is described.
Autoren
  • Soumya Basu
  • S Majumder
  • S Chatterjee
  • A Ganguly
  • T Efferth
  • SK Choudhuri
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/19454505
ISSN
0258-851X
Ausgabe der Veröffentlichung
3
Zeitschrift
In Vivo
Schlüsselwörter
  • Animals
  • Chromatography, Liquid
  • Copper
  • Glutathione
  • Male
  • Mice
  • Models, Molecular
  • Spectrum Analysis
Sprache
eng
Country
Greece
Paginierung
401 - 408
PII
23/3/401
Datum der Veröffentlichung
2009
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2009
Titel
Detection and characterization of a glutathione conjugate of a novel copper complex.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
23

Data source: PubMed

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