Neglected Diseases Caused By Bacterial Infections

Autoren

M Bechtle
S Chen
T Efferth

DOI

10.2174/092986710789957814

ISSN

0929-8673

Ausgabe der Veröffentlichung

1

Zeitschrift

Current Medicinal Chemistry

Sprache

en

Paginierung

42 - 60

Datum der Veröffentlichung

2010

Status

Published

Herausgeber

Bentham Science Publishers Ltd.

Herausgeber URL

http://dx.doi.org/10.2174/092986710789957814

Datum der Datenerfassung

2015

Titel

Neglected Diseases Caused By Bacterial Infections

Ausgabe der Zeitschrift

17

Data source: Crossref

Abstract

Bacterial infections represent a major health problem, especially in third world countries. In endemic regions, large populations of people are greatly affected, but the medical care is very limited. In this review, the neglected diseases buruli ulcer and trachoma are elucidated. Buruli ulcer is caused by Mycobacterium ulcerans which produces an outstanding immunosuppressive toxin mycolactone that induces an ulcerative, necrotic skin disease. Until today, only the combination of rifampin/streptomycin is used to treat buruli ulcer. However, this therapy is ineffective and expensive. Here, we report new findings that suggest pharmaceutical formulations such as rifapentine, in combination with clarithromycin or moxifloxacin that have shown promising results in mice footpad trials. Moreover, alternative treatment options such as heat therapy, nitric oxide cremes and French clay show bactericidal effects. The genotyping of M. ulcerans also promises new ways of finding drug targets and vaccines. Trachoma, induced by the bacterium Chlamydia trachomatis, is the primary infectious cause of blindness worldwide. Recurrent infections lead to chronic inflammation of the upper tarsal conjunctiva. As a consequence, scarring and distortion of the eye lids occur, eventually resulting in blindness. First-line medications for trachoma treatment are bacteriostatic agents such as topically applied tetracylines and systematically administered azithromycin. Surgery, environmental improvements and personal hygiene are further crucial factors in controlling trachoma. Moreover, efforts are being undertaken towards the development of vaccine systems, with the major outer membrane protein and the polymorphic membrane protein acting as attractive candidates.

Addresses

Department of Pharmaceutical Biology and Biochemistry, Institute of Pharmacy, University of Mainz, Staudinger Weg 5, Mainz, Germany.

Autoren

M Bechtle
S Chen
T Efferth
T Efferth

DOI

10.2174/092986710789957814

eISSN

1875-533X

Externe Identifier

PubMed Identifier: 19941479

Open access

false

ISSN

0929-8673

Ausgabe der Veröffentlichung

1

Zeitschrift

Current medicinal chemistry

Schlüsselwörter

Animals
Humans
Chlamydia trachomatis
Mycobacterium ulcerans
Trachoma
Rare Diseases
Anti-Bacterial Agents
Vaccination
Buruli Ulcer

Sprache

eng

Medium

Print

Paginierung

42 - 60

Datum der Veröffentlichung

2010

Status

Published

Datum der Datenerfassung

2009

Titel

Neglected diseases caused by bacterial infections.

Sub types

Review
Journal Article

Ausgabe der Zeitschrift

17

Data source: Europe PubMed Central

Abstract

Bacterial infections represent a major health problem, especially in third world countries. In endemic regions, large populations of people are greatly affected, but the medical care is very limited. In this review, the neglected diseases buruli ulcer and trachoma are elucidated. Buruli ulcer is caused by Mycobacterium ulcerans which produces an outstanding immunosuppressive toxin mycolactone that induces an ulcerative, necrotic skin disease. Until today, only the combination of rifampin/streptomycin is used to treat buruli ulcer. However, this therapy is ineffective and expensive. Here, we report new findings that suggest pharmaceutical formulations such as rifapentine, in combination with clarithromycin or moxifloxacin that have shown promising results in mice footpad trials. Moreover, alternative treatment options such as heat therapy, nitric oxide cremes and French clay show bactericidal effects. The genotyping of M. ulcerans also promises new ways of finding drug targets and vaccines. Trachoma, induced by the bacterium Chlamydia trachomatis, is the primary infectious cause of blindness worldwide. Recurrent infections lead to chronic inflammation of the upper tarsal conjunctiva. As a consequence, scarring and distortion of the eye lids occur, eventually resulting in blindness. First-line medications for trachoma treatment are bacteriostatic agents such as topically applied tetracylines and systematically administered azithromycin. Surgery, environmental improvements and personal hygiene are further crucial factors in controlling trachoma. Moreover, efforts are being undertaken towards the development of vaccine systems, with the major outer membrane protein and the polymorphic membrane protein acting as attractive candidates.

Date of acceptance

2009

Autoren

M Bechtle
S Chen
T Efferth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/19941479

DOI

10.2174/092986710789957814

eISSN

1875-533X

Ausgabe der Veröffentlichung

1

Zeitschrift

Curr Med Chem

Schlüsselwörter

Animals
Anti-Bacterial Agents
Buruli Ulcer
Chlamydia trachomatis
Humans
Mycobacterium ulcerans
Rare Diseases
Trachoma
Vaccination

Sprache

eng

Country

United Arab Emirates

Paginierung

42 - 60

PII

CMC - AbsEpub/2010 - 004

Datum der Veröffentlichung

2010

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2010

Titel

Neglected diseases caused by bacterial infections.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

17

Data source: PubMed

Neglected Diseases Caused By Bacterial Infections

Tools