Traditional Chinese Medicines (TCMs) for Molecular Targeted Therapies of Tumours

Publication type:
Journal article
Metadata:
Autoren
  • Mahmoud Youns
  • Jorg D. Hoheisel
  • Thomas Efferth
DOI
10.2174/157016310791162730
ISSN
1570-1638
Ausgabe der Veröffentlichung
1
Zeitschrift
Current Drug Discovery Technologies
Sprache
en
Paginierung
37 - 45
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/157016310791162730
Datum der Datenerfassung
2015
Titel
Traditional Chinese Medicines (TCMs) for Molecular Targeted Therapies of Tumours
Ausgabe der Zeitschrift
7

Data source: Crossref

Other metadata sources:
Abstract
Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or complementary medicine. TCM represents a holistic approach and lacks high-quality scientific evidence on its effectiveness. Therefore, it is frequently regarded with some scepticism by western academic medicine. In this review, we report that application of modern technologies allowed identification of novel molecular targets modulating the anti-tumour activity of natural products derived from TCM. Moreover, we tried to cross the bridge between TCM and Western modern medicine to be able to implement them for the sake of cancer patients.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy, University of Mainz, Staudinger Weg 5, Mainz, Germany.
Autoren
DOI
10.2174/157016310791162730
eISSN
1875-6220
Externe Identifier
  • PubMed Identifier: 20156142
Open access
false
ISSN
1570-1638
Ausgabe der Veröffentlichung
1
Zeitschrift
Current drug discovery technologies
Schlüsselwörter
  • Animals
  • Humans
  • Neoplasms
  • Arsenicals
  • Oxides
  • Curcumin
  • Artemisinins
  • Berberine
  • Cantharidin
  • Drugs, Chinese Herbal
  • Antineoplastic Agents, Phytogenic
  • Biological Products
  • Complementary Therapies
  • Medicine, Chinese Traditional
  • Drug Delivery Systems
  • Drug Screening Assays, Antitumor
  • Models, Biological
  • Arsenic Trioxide
  • Artesunate
Sprache
eng
Medium
Print
Paginierung
37 - 45
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
7

Data source: Europe PubMed Central

Abstract
Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or complementary medicine. TCM represents a holistic approach and lacks high-quality scientific evidence on its effectiveness. Therefore, it is frequently regarded with some scepticism by western academic medicine. In this review, we report that application of modern technologies allowed identification of novel molecular targets modulating the anti-tumour activity of natural products derived from TCM. Moreover, we tried to cross the bridge between TCM and Western modern medicine to be able to implement them for the sake of cancer patients.
Date of acceptance
2009
Autoren
  • Mahmoud Youns
  • Jörg D Hoheisel
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20156142
DOI
10.2174/157016310791162730
eISSN
1875-6220
Ausgabe der Veröffentlichung
1
Zeitschrift
Curr Drug Discov Technol
Schlüsselwörter
  • Animals
  • Antineoplastic Agents, Phytogenic
  • Arsenic Trioxide
  • Arsenicals
  • Artemisinins
  • Artesunate
  • Berberine
  • Biological Products
  • Cantharidin
  • Complementary Therapies
  • Curcumin
  • Drug Delivery Systems
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal
  • Humans
  • Medicine, Chinese Traditional
  • Models, Biological
  • Neoplasms
  • Oxides
Sprache
eng
Country
United Arab Emirates
Paginierung
37 - 45
PII
BSP/CDDT/E-Pub/00006
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
7

Data source: PubMed

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