Antioxidant Activities and Xanthine Oxidase Inhibitory Effects of Extracts and Main Polyphenolic Compounds Obtained from Geranium sibiricum L.
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Nan Wu
- Yuangang Zu
- Yujie Fu
- Yu Kong
- Jintong Zhao
- Xiaojuan Li
- Ji Li
- Michael Wink
- Thomas Efferth
- DOI
- 10.1021/jf904593n
- eISSN
- 1520-5118
- ISSN
- 0021-8561
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Journal of Agricultural and Food Chemistry
- Sprache
- en
- Online publication date
- 2010
- Paginierung
- 4737 - 4743
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/jf904593n
- Datum der Datenerfassung
- 2023
- Titel
- Antioxidant Activities and Xanthine Oxidase Inhibitory Effects of Extracts and Main Polyphenolic Compounds Obtained from <i>Geranium sibiricum</i> L.
- Ausgabe der Zeitschrift
- 58
Data source: Crossref
- Other metadata sources:
-
- Abstract
- The antioxidant capacity and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds of Geranium sibiricum were studied in the present work. The antioxidant capacity was evaluated by ferric reducing antioxidant power, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, superoxide radical scavenging, nitric oxide scavenging, beta-carotene-linoleic acid bleaching, and reducing power assays. Among the extracts and four fractions, the ethyl acetate fraction showed the highest phenolic content (425.36 +/- 9.70 mg of gallic acid equivalent/g extracts) and the best antioxidant activity. The IC(50) values of the ethyl acetate fraction were 0.93, 3.32, 2.06, 2.66, and 1.64 microg/mL in the DPPH radical scavenging, superoxide radical scavenging, nitric oxide scavenging, beta-carotene-linoleic acid bleaching, and reducing power assays, respectively. Of the polyphenolic compounds separated from the ethyl acetate fraction, geraniin showed a higher activity than corilagin and gallic acid. The IC(50) values ranged from 0.87 to 2.53 microM, which were even lower than the positive control (except for allopurinol). All test samples except for the petroleum ether fraction showed xanthine oxidase inhibitory effects. We conclude that G. sibiricum represents a valuable natural antioxidant source and is potentially applicable in the healthy food industry.
- Addresses
- Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
- Autoren
- Nan Wu
- Yuangang Zu
- Yujie Fu
- Yu Kong
- Jintong Zhao
- Xiaojuan Li
- Ji Li
- Michael Wink
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1021/jf904593n
- eISSN
- 1520-5118
- Externe Identifier
- PubMed Identifier: 20205393
- Open access
- false
- ISSN
- 0021-8561
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- Journal of agricultural and food chemistry
- Schlüsselwörter
- Geranium
- Phenols
- Flavonoids
- Xanthine Oxidase
- Plant Extracts
- Enzyme Inhibitors
- Antioxidants
- Chromatography, High Pressure Liquid
- Polyphenols
- Sprache
- eng
- Medium
- Paginierung
- 4737 - 4743
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Datum der Datenerfassung
- 2010
- Titel
- Antioxidant activities and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds obtained from Geranium sibiricum L.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 58
Data source: Europe PubMed Central
- Abstract
- The antioxidant capacity and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds of Geranium sibiricum were studied in the present work. The antioxidant capacity was evaluated by ferric reducing antioxidant power, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, superoxide radical scavenging, nitric oxide scavenging, beta-carotene-linoleic acid bleaching, and reducing power assays. Among the extracts and four fractions, the ethyl acetate fraction showed the highest phenolic content (425.36 +/- 9.70 mg of gallic acid equivalent/g extracts) and the best antioxidant activity. The IC(50) values of the ethyl acetate fraction were 0.93, 3.32, 2.06, 2.66, and 1.64 microg/mL in the DPPH radical scavenging, superoxide radical scavenging, nitric oxide scavenging, beta-carotene-linoleic acid bleaching, and reducing power assays, respectively. Of the polyphenolic compounds separated from the ethyl acetate fraction, geraniin showed a higher activity than corilagin and gallic acid. The IC(50) values ranged from 0.87 to 2.53 microM, which were even lower than the positive control (except for allopurinol). All test samples except for the petroleum ether fraction showed xanthine oxidase inhibitory effects. We conclude that G. sibiricum represents a valuable natural antioxidant source and is potentially applicable in the healthy food industry.
- Autoren
- Nan Wu
- Yuangang Zu
- Yujie Fu
- Yu Kong
- Jintong Zhao
- Xiaojuan Li
- Ji Li
- Michael Wink
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/20205393
- DOI
- 10.1021/jf904593n
- eISSN
- 1520-5118
- Ausgabe der Veröffentlichung
- 8
- Zeitschrift
- J Agric Food Chem
- Schlüsselwörter
- Antioxidants
- Chromatography, High Pressure Liquid
- Enzyme Inhibitors
- Flavonoids
- Geranium
- Phenols
- Plant Extracts
- Polyphenols
- Xanthine Oxidase
- Sprache
- eng
- Country
- United States
- Paginierung
- 4737 - 4743
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2010
- Titel
- Antioxidant activities and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds obtained from Geranium sibiricum L.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 58
Data source: PubMed
- Beziehungen:
- Property of