Trypanosomatid Parasites Causing Neglected Diseases

Publication type:
Journal article
Metadata:
Autoren
  • K Nussbaum
  • J Honek
  • CMCVC Cadmus
  • T Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000275937300007&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.2174/092986710790979953
eISSN
1875-533X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 573TH
  • PubMed Identifier: 20166934
ISSN
0929-8673
Ausgabe der Veröffentlichung
15
Zeitschrift
CURRENT MEDICINAL CHEMISTRY
Schlüsselwörter
  • Neglected disease
  • visceral leishmaniasis
  • Leishmania infantum
  • American trypanosomiasis
  • Trypanosoma cruzi
  • human African trypanosomiasis
  • Trypanosoma brucei
  • Chemotherapy
Paginierung
1594 - 1617
Datum der Veröffentlichung
2010
Status
Published
Titel
Trypanosomatid Parasites Causing Neglected Diseases
Sub types
  • Review
Ausgabe der Zeitschrift
17

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • K Nussbaum
  • J Honek
  • C C.v.C. Cadmus
  • T Efferth
DOI
10.2174/092986710790979953
ISSN
0929-8673
Ausgabe der Veröffentlichung
15
Zeitschrift
Current Medicinal Chemistry
Sprache
en
Paginierung
1594 - 1617
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/092986710790979953
Datum der Datenerfassung
2015
Titel
Trypanosomatid Parasites Causing Neglected Diseases
Ausgabe der Zeitschrift
17

Data source: Crossref

Abstract
Parasitic diseases such as Kala azar (visceral leishmaniasis), Chagas disease human (American trypanosomiasis) and African sleeping sickness (African trypanosomiasis) are affecting more than 27 million people worldwide. They are categorized amongst the most important neglected diseases causing approximately 150,000 deaths annually. As no vaccination is available, treatment is solely dependent on chemotherapeutic drugs. This review provides a comprehensive insight into the treatment of Kala azar, Chagas disease and African sleeping sickness. In addition to established drugs, novel small molecule- based therapeutic approaches are discussed. Drugs currently used for the treatment of Kala azar include pentavalent antimonials, Amphotericin B, Miltefosine, and Paromomycin. Liposomal formulations such as AmBisome provide promising alternatives. Furthermore, antiproliferative compounds might open new avenues in Kala azar treatment. Regarding Chagas disease, chemotherapy is based on two drugs, Nifurtimox and Benznidazole. However, sequencing of T. cruzi genome in the year 2005 raises a hope for new drug targets. Proteases, sterols and sialic acids are potential promising drug targets. Suramin, Pentamidine, Melarsporol and Eflornithine are well-established drugs to treat African sleeping sickness. New treatment options include combination therapy of Eflornithine and Nifurtimox, a Chagas disease therapeutic.. However, all approved chemotherapeutic compounds for trypanosomatid diseases suffer from high toxicity. Further, increasing resistance limits their efficacy and compliance.
Addresses
  • Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls University Heidelberg, Im Neuenheimer Feld 364,69120 Heidelberg, Germany.
Autoren
  • K Nussbaum
  • J Honek
  • CMCVC Cadmus
  • T Efferth
  • T Efferth
DOI
10.2174/092986710790979953
eISSN
1875-533X
Externe Identifier
  • PubMed Identifier: 20166934
Open access
false
ISSN
0929-8673
Ausgabe der Veröffentlichung
15
Zeitschrift
Current medicinal chemistry
Schlüsselwörter
  • Humans
  • Leishmaniasis, Visceral
  • Chagas Disease
  • Trypanosomiasis, African
  • Ergosterol
  • Trypanocidal Agents
  • Cysteine Proteases
Sprache
eng
Medium
Print
Paginierung
1594 - 1617
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Trypanosomatid parasites causing neglected diseases.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
17

Data source: Europe PubMed Central

Abstract
Parasitic diseases such as Kala azar (visceral leishmaniasis), Chagas disease human (American trypanosomiasis) and African sleeping sickness (African trypanosomiasis) are affecting more than 27 million people worldwide. They are categorized amongst the most important neglected diseases causing approximately 150,000 deaths annually. As no vaccination is available, treatment is solely dependent on chemotherapeutic drugs. This review provides a comprehensive insight into the treatment of Kala azar, Chagas disease and African sleeping sickness. In addition to established drugs, novel small molecule- based therapeutic approaches are discussed. Drugs currently used for the treatment of Kala azar include pentavalent antimonials, Amphotericin B, Miltefosine, and Paromomycin. Liposomal formulations such as AmBisome provide promising alternatives. Furthermore, antiproliferative compounds might open new avenues in Kala azar treatment. Regarding Chagas disease, chemotherapy is based on two drugs, Nifurtimox and Benznidazole. However, sequencing of T. cruzi genome in the year 2005 raises a hope for new drug targets. Proteases, sterols and sialic acids are potential promising drug targets. Suramin, Pentamidine, Melarsporol and Eflornithine are well-established drugs to treat African sleeping sickness. New treatment options include combination therapy of Eflornithine and Nifurtimox, a Chagas disease therapeutic.. However, all approved chemotherapeutic compounds for trypanosomatid diseases suffer from high toxicity. Further, increasing resistance limits their efficacy and compliance.
Date of acceptance
2010
Autoren
  • K Nussbaum
  • J Honek
  • CMCVC Cadmus
  • T Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20166934
DOI
10.2174/092986710790979953
eISSN
1875-533X
Ausgabe der Veröffentlichung
15
Zeitschrift
Curr Med Chem
Schlüsselwörter
  • Chagas Disease
  • Cysteine Proteases
  • Ergosterol
  • Humans
  • Leishmaniasis, Visceral
  • Trypanocidal Agents
  • Trypanosomiasis, African
Sprache
eng
Country
United Arab Emirates
Paginierung
1594 - 1617
PII
BSP/CMC/E-Pub/ 083
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
Trypanosomatid parasites causing neglected diseases.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
17

Data source: PubMed

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