Natural Products in Structure-Assisted Design of Molecular Cancer Therapeutics

Publication type:
Journal article
Metadata:
Autoren
  • Petra H Pfisterer
  • Gerhard Wolber
  • Thomas Efferth
  • Judith M Rollinger
  • Hermann Stuppner
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000277126000007&DestLinkType=FullRecord&DestApp=WOS_CPL
eISSN
1873-4286
Externe Identifier
  • Clarivate Analytics Document Solution ID: 589DO
  • PubMed Identifier: 20222854
ISSN
1381-6128
Ausgabe der Veröffentlichung
15
Zeitschrift
CURRENT PHARMACEUTICAL DESIGN
Schlüsselwörter
  • Natural product
  • phytochemicals
  • cancer
  • drug discovery
  • in silico techniques
  • molecular modeling
  • virtual screening
  • docking
Paginierung
1718 - 1741
Datum der Veröffentlichung
2010
Status
Published
Titel
Natural Products in Structure-Assisted Design of Molecular Cancer Therapeutics
Sub types
  • Review
Ausgabe der Zeitschrift
16

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Petra H. Pfisterer
  • Gerhard Wolber
  • Thomas Efferth
  • Judith M. Rollinger
  • Hermann Stuppner
DOI
10.2174/138161210791164027
ISSN
1381-6128
Ausgabe der Veröffentlichung
15
Zeitschrift
Current Pharmaceutical Design
Sprache
en
Paginierung
1718 - 1741
Datum der Veröffentlichung
2010
Status
Published
Herausgeber
Bentham Science Publishers Ltd.
Herausgeber URL
http://dx.doi.org/10.2174/138161210791164027
Datum der Datenerfassung
2015
Titel
Natural Products in Structure-Assisted Design of Molecular Cancer Therapeutics
Ausgabe der Zeitschrift
16

Data source: Crossref

Abstract
Since the late 1990's, novel insights into molecular biology and carcinogenesis enabled the rational design of mechanism-based anticancer therapeutics. The large number of natural product (NP)-derived drugs currently under clinical evaluation and the recent approval of temsirolimus (Torisel) as a first mTOR protein kinase inhibitor indicate that NPs have to be considered not only as a seminal source of cytotoxic, but also as a source of molecularly targeted agents. Whereas molecular modeling is well established as an important and successful method to discover and rationalize bioactivities in medicinal chemistry research, its application has also proven to be also a powerful tool in the field of NPs. This review highlights the impact of computer-assisted approaches on NPs as molecularly targeted anticancer drugs. Examples of applications are provided focusing on innovative targets such as protein kinases, tumour vasculature, epigenetic modulators, heat shock protein (Hsp) 90, and direct apoptosis enhancers.
Addresses
  • Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck, Austria.
Autoren
  • PH Pfisterer
  • G Wolber
  • T Efferth
  • T Efferth
  • JM Rollinger
  • H Stuppner
DOI
10.2174/138161210791164027
eISSN
1873-4286
Externe Identifier
  • PubMed Identifier: 20222854
Open access
false
ISSN
1381-6128
Ausgabe der Veröffentlichung
15
Zeitschrift
Current pharmaceutical design
Schlüsselwörter
  • Sirolimus
  • Plant Preparations
  • Antineoplastic Agents
  • Biological Products
  • Apoptosis
  • Epigenesis, Genetic
  • Structure-Activity Relationship
  • Drug Design
  • Models, Molecular
  • HSP90 Heat-Shock Proteins
Sprache
eng
Medium
Print
Paginierung
1718 - 1741
Datum der Veröffentlichung
2010
Status
Published
Datum der Datenerfassung
2010
Titel
Natural products in structure-assisted design of molecular cancer therapeutics.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
16

Data source: Europe PubMed Central

Abstract
Since the late 1990's, novel insights into molecular biology and carcinogenesis enabled the rational design of mechanism-based anticancer therapeutics. The large number of natural product (NP)-derived drugs currently under clinical evaluation and the recent approval of temsirolimus (Torisel) as a first mTOR protein kinase inhibitor indicate that NPs have to be considered not only as a seminal source of cytotoxic, but also as a source of molecularly targeted agents. Whereas molecular modeling is well established as an important and successful method to discover and rationalize bioactivities in medicinal chemistry research, its application has also proven to be also a powerful tool in the field of NPs. This review highlights the impact of computer-assisted approaches on NPs as molecularly targeted anticancer drugs. Examples of applications are provided focusing on innovative targets such as protein kinases, tumour vasculature, epigenetic modulators, heat shock protein (Hsp) 90, and direct apoptosis enhancers.
Date of acceptance
2010
Autoren
  • PH Pfisterer
  • G Wolber
  • T Efferth
  • JM Rollinger
  • H Stuppner
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/20222854
DOI
10.2174/138161210791164027
eISSN
1873-4286
Ausgabe der Veröffentlichung
15
Zeitschrift
Curr Pharm Des
Schlüsselwörter
  • Antineoplastic Agents
  • Apoptosis
  • Biological Products
  • Drug Design
  • Epigenesis, Genetic
  • HSP90 Heat-Shock Proteins
  • Models, Molecular
  • Plant Preparations
  • Sirolimus
  • Structure-Activity Relationship
Sprache
eng
Country
United Arab Emirates
Paginierung
1718 - 1741
PII
BSP/CPD/E-Pub/00067
Datum der Veröffentlichung
2010
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2010
Titel
Natural products in structure-assisted design of molecular cancer therapeutics.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
16

Data source: PubMed

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