Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

Autoren

Thomas E Kraft
Daniel Parisotto
Christina Schempp
Thomas Efferth

DOI

10.1080/10408390802248627

eISSN

1549-7852

ISSN

1040-8398

Ausgabe der Veröffentlichung

9

Zeitschrift

Critical Reviews in Food Science and Nutrition

Sprache

en

Paginierung

782 - 799

Datum der Veröffentlichung

2009

Status

Published

Herausgeber

Informa UK Limited

Herausgeber URL

http://dx.doi.org/10.1080/10408390802248627

Datum der Datenerfassung

2024

Titel

Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

Ausgabe der Zeitschrift

49

Data source: Crossref

Abstract

Resveratrol, a red wine constituent, has been known for its cardioprotective effects. Recent data give ample evidence that resveratrol can act as a chemopreventive agent as well. Tumor initation, promotion, and progression are affected by resveratrol via multiple pathways, which are discussed in this review. Resveratrol has anti-inflammatory effects by counteracting NF-kappa B and AP-1 transcription and can prevent bioactivation of procarcinogens by interacting with drug metabolizing enzymes. Furthermore, resveratrol exerts antioxidant activities, hence contributing to the prevention of tumor initiation. Growing or metastasizing carcinomas are inhibited by resveratrol through prevention of angiogenesis by inhibiting VEGF and matrix metalloproteases. Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins. Although there has been remarkable evidence for resveratrol as a potent chemopreventive agent in vitro, it seems that the low bioavailability of resveratrol in humans could interfere with a successful in vivo treatment. Nevertheless, resveratrol offers two major advantages over conventional chemotherapy. The cytotoxic effects of resveratrol on healthy cells can be neglected, and, as several pathways leading to chemotherapeutic effects are activated by resveratrol, chemoresistance-inducing mutations in cancer cells can be overcome.

Addresses

University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Germany. thomas kraft@gmx.net

Autoren

Thomas E Kraft
Daniel Parisotto
Christina Schempp
Thomas Efferth
Thomas Efferth

DOI

10.1080/10408390802248627

eISSN

1549-7852

Externe Identifier

PubMed Identifier: 20443159

Open access

false

ISSN

1040-8398

Ausgabe der Veröffentlichung

9

Zeitschrift

Critical reviews in food science and nutrition

Schlüsselwörter

Humans
Neoplasms
Stilbenes
Angiogenesis Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Anticarcinogenic Agents
Antineoplastic Agents, Phytogenic
Apoptosis
Biological Availability
Wine
Resveratrol

Sprache

eng

Medium

Print

Paginierung

782 - 799

Datum der Veröffentlichung

2009

Status

Published

Datum der Datenerfassung

2010

Titel

Fighting cancer with red wine? Molecular mechanisms of resveratrol.

Sub types

Review
Journal Article

Ausgabe der Zeitschrift

49

Data source: Europe PubMed Central

Abstract

Resveratrol, a red wine constituent, has been known for its cardioprotective effects. Recent data give ample evidence that resveratrol can act as a chemopreventive agent as well. Tumor initation, promotion, and progression are affected by resveratrol via multiple pathways, which are discussed in this review. Resveratrol has anti-inflammatory effects by counteracting NF-kappa B and AP-1 transcription and can prevent bioactivation of procarcinogens by interacting with drug metabolizing enzymes. Furthermore, resveratrol exerts antioxidant activities, hence contributing to the prevention of tumor initiation. Growing or metastasizing carcinomas are inhibited by resveratrol through prevention of angiogenesis by inhibiting VEGF and matrix metalloproteases. Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins. Although there has been remarkable evidence for resveratrol as a potent chemopreventive agent in vitro, it seems that the low bioavailability of resveratrol in humans could interfere with a successful in vivo treatment. Nevertheless, resveratrol offers two major advantages over conventional chemotherapy. The cytotoxic effects of resveratrol on healthy cells can be neglected, and, as several pathways leading to chemotherapeutic effects are activated by resveratrol, chemoresistance-inducing mutations in cancer cells can be overcome.

Autoren

Thomas E Kraft
Daniel Parisotto
Christina Schempp
Thomas Efferth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/20443159

DOI

10.1080/10408390802248627

eISSN

1549-7852

Ausgabe der Veröffentlichung

9

Zeitschrift

Crit Rev Food Sci Nutr

Schlüsselwörter

Angiogenesis Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Anticarcinogenic Agents
Antineoplastic Agents, Phytogenic
Apoptosis
Biological Availability
Humans
Neoplasms
Resveratrol
Stilbenes
Wine

Sprache

eng

Country

United States

Paginierung

782 - 799

PII

915582861

Datum der Veröffentlichung

2009

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2010

Titel

Fighting cancer with red wine? Molecular mechanisms of resveratrol.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

49

Data source: PubMed

Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

Tools