Strategies for Overcoming Chemotherapy Resistance in Enterohepatic Tumours

Autoren

JJG Marin
B Castano
AG Blazquez
R Rosales
T Efferth
MJ Monte

DOI

10.2174/156652410791608261

ISSN

1566-5240

Ausgabe der Veröffentlichung

5

Zeitschrift

Current Molecular Medicine

Sprache

en

Paginierung

467 - 485

Datum der Veröffentlichung

2010

Status

Published

Herausgeber

Bentham Science Publishers Ltd.

Herausgeber URL

http://dx.doi.org/10.2174/156652410791608261

Datum der Datenerfassung

2015

Titel

Strategies for Overcoming Chemotherapy Resistance in Enterohepatic Tumours

Ausgabe der Zeitschrift

10

Data source: Crossref

Abstract

When considered together, enterohepatic tumours, i.e., those affecting the liver, the biliary tree and gallbladder and the intestine, constitute the first cause of death due to cancer. Although in many cases surgery and radiotherapy are efficacious, these therapeutic strategies cannot always be implemented. Moreover, even when the removal of tumours is possible, pre- and post-operative pharmacological adjuvant regimens are often needed. However, one important limitation to the use of cytostatic drugs to treat enterohepatic tumours is that they generally exhibit marked refractivity to currently available pharmacological approaches. In addition, most of them increase their chemoresistance during treatment. In view of the high refractivity of these tumours to anti-cancer drugs and the existence of undesirable side effects, both of which are drawbacks in the available chemotherapy, several novel therapeutic approaches have been devised. The purpose of the present review is to offer some insight into the different types of strategies that have already been evaluated and incorporated into clinical practice, such as therapies based on the use of molecular targets, as well as into the approaches that are still under experimental development, such as the chemosensitization of cancer cells, genetic manipulation of tumour or host cells, and cell-specific enhancement of intracellular concentrations of the active agent by efficient targeting of pro-drugs or by using inhibitors of efflux pumps.

Addresses

Laboratory of Experimental Hepatology and Drug Targeting, Campus Miguel de Unamuno, University of Salamanca, Salamanca, Spain. jjgmarin@usal.es

Autoren

JJG Marin
B Castaño
AG Blazquez
R Rosales
T Efferth
T Efferth
MJ Monte

DOI

10.2174/156652410791608261

eISSN

1875-5666

Externe Identifier

PubMed Identifier: 20540704

Open access

false

ISSN

1566-5240

Ausgabe der Veröffentlichung

5

Zeitschrift

Current molecular medicine

Schlüsselwörter

Animals
Humans
Digestive System Neoplasms
Antineoplastic Agents
Prodrugs
Combined Modality Therapy
Drug Delivery Systems
Drug Resistance, Neoplasm
Genetic Therapy

Sprache

eng

Medium

Print

Paginierung

467 - 485

Datum der Veröffentlichung

2010

Status

Published

Datum der Datenerfassung

2010

Titel

Strategies for overcoming chemotherapy resistance in enterohepatic tumours.

Sub types

Research Support, Non-U.S. Gov't
Review
Journal Article

Ausgabe der Zeitschrift

10

Data source: Europe PubMed Central

Abstract

When considered together, enterohepatic tumours, i.e., those affecting the liver, the biliary tree and gallbladder and the intestine, constitute the first cause of death due to cancer. Although in many cases surgery and radiotherapy are efficacious, these therapeutic strategies cannot always be implemented. Moreover, even when the removal of tumours is possible, pre- and post-operative pharmacological adjuvant regimens are often needed. However, one important limitation to the use of cytostatic drugs to treat enterohepatic tumours is that they generally exhibit marked refractivity to currently available pharmacological approaches. In addition, most of them increase their chemoresistance during treatment. In view of the high refractivity of these tumours to anti-cancer drugs and the existence of undesirable side effects, both of which are drawbacks in the available chemotherapy, several novel therapeutic approaches have been devised. The purpose of the present review is to offer some insight into the different types of strategies that have already been evaluated and incorporated into clinical practice, such as therapies based on the use of molecular targets, as well as into the approaches that are still under experimental development, such as the chemosensitization of cancer cells, genetic manipulation of tumour or host cells, and cell-specific enhancement of intracellular concentrations of the active agent by efficient targeting of pro-drugs or by using inhibitors of efflux pumps.

Date of acceptance

2009

Autoren

JJG Marin
B Castaño
AG Blazquez
R Rosales
T Efferth
MJ Monte

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/20540704

DOI

10.2174/156652410791608261

eISSN

1875-5666

Ausgabe der Veröffentlichung

5

Zeitschrift

Curr Mol Med

Schlüsselwörter

Animals
Antineoplastic Agents
Combined Modality Therapy
Digestive System Neoplasms
Drug Delivery Systems
Drug Resistance, Neoplasm
Genetic Therapy
Humans
Prodrugs

Sprache

eng

Country

Netherlands

Paginierung

467 - 485

PII

CMM # 52

Datum der Veröffentlichung

2010

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2010

Titel

Strategies for overcoming chemotherapy resistance in enterohepatic tumours.

Sub types

Journal Article
Research Support, Non-U.S. Gov't
Review

Ausgabe der Zeitschrift

10

Data source: PubMed

Strategies for Overcoming Chemotherapy Resistance in Enterohepatic Tumours

Tools