Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Cindy Horwedel
- Svetlana B Tsogoeva
- Shengwei Wei
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000279282300003&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1021/jm100404t
- Externe Identifier
- Clarivate Analytics Document Solution ID: 617LM
- PubMed Identifier: 20527917
- ISSN
- 0022-2623
- Ausgabe der Veröffentlichung
- 13
- Zeitschrift
- JOURNAL OF MEDICINAL CHEMISTRY
- Paginierung
- 4842 - 4848
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Titel
- Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 53
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Cindy Horwedel
- Svetlana B Tsogoeva
- Shengwei Wei
- Thomas Efferth
- DOI
- 10.1021/jm100404t
- eISSN
- 1520-4804
- ISSN
- 0022-2623
- Ausgabe der Veröffentlichung
- 13
- Zeitschrift
- Journal of Medicinal Chemistry
- Sprache
- en
- Online publication date
- 2010
- Paginierung
- 4842 - 4848
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Herausgeber
- American Chemical Society (ACS)
- Herausgeber URL
- http://dx.doi.org/10.1021/jm100404t
- Datum der Datenerfassung
- 2023
- Titel
- Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells
- Ausgabe der Zeitschrift
- 53
Data source: Crossref
- Abstract
- A novel approach to circumvent multidrug resistance is hybridization of natural products in dimers. We analyzed homodimers of two artesunic acid molecules and heterohybrids of artesunic acid and betulin in human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR5000 leukemia cells. Multidrug-resistant cells were not cross-resistant to the novel compounds. Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species.
- Addresses
- Pharmaceutical Biology (C015), German Cancer Research Center, Heidelberg, Germany.
- Autoren
- Cindy Horwedel
- Svetlana B Tsogoeva
- Shengwei Wei
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1021/jm100404t
- eISSN
- 1520-4804
- Externe Identifier
- PubMed Identifier: 20527917
- Open access
- false
- ISSN
- 0022-2623
- Ausgabe der Veröffentlichung
- 13
- Zeitschrift
- Journal of medicinal chemistry
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Leukemia
- Reactive Oxygen Species
- Formazans
- Succinates
- Artemisinins
- Triterpenes
- Flow Cytometry
- Magnetic Resonance Spectroscopy
- Spectrometry, Mass, Electrospray Ionization
- Cell Cycle
- Apoptosis
- Cell Survival
- Drug Resistance, Neoplasm
- Sprache
- eng
- Medium
- Paginierung
- 4842 - 4848
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Datum der Datenerfassung
- 2010
- Titel
- Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 53
Data source: Europe PubMed Central
- Abstract
- A novel approach to circumvent multidrug resistance is hybridization of natural products in dimers. We analyzed homodimers of two artesunic acid molecules and heterohybrids of artesunic acid and betulin in human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR5000 leukemia cells. Multidrug-resistant cells were not cross-resistant to the novel compounds. Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species.
- Autoren
- Cindy Horwedel
- Svetlana B Tsogoeva
- Shengwei Wei
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/20527917
- DOI
- 10.1021/jm100404t
- eISSN
- 1520-4804
- Ausgabe der Veröffentlichung
- 13
- Zeitschrift
- J Med Chem
- Schlüsselwörter
- Apoptosis
- Artemisinins
- Cell Cycle
- Cell Line, Tumor
- Cell Survival
- Drug Resistance, Neoplasm
- Flow Cytometry
- Formazans
- Humans
- Leukemia
- Magnetic Resonance Spectroscopy
- Reactive Oxygen Species
- Spectrometry, Mass, Electrospray Ionization
- Succinates
- Triterpenes
- Sprache
- eng
- Country
- United States
- Paginierung
- 4842 - 4848
- Datum der Veröffentlichung
- 2010
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2010
- Titel
- Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 53
Data source: PubMed
- Beziehungen:
- Property of